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Clinical Trials in China / NCT06856382
Active, not recruiting Observational

The Association Between Microplastics and Macrogenomics and Metabolomics in Gastric Cancer

NCT06856382 · tracked via the Priya Life Science China tracker
Sponsor
Dong Peng
Phase
Observational
Started
2024-12-01
Last updated
2025-03-04

Condition(s) studied

Gastric Cancers

Investigational drug(s) / intervention(s)

gastric cancer

gastric cancer: Patients diagnosed with gastric cancer by pathological biopsy.

Study summary

The aim of this study was to identify and quantify microplastics in blood, stool, and tumor surgical specimens from gastric cancer patients by analyzing the nature, type, and abundance of microplastics using laser direct infrared (LDIR) spectroscopy, scanning electron microscopy (SEM), and pyrolysis-gas chromatography-mass spectrometry (Py-GC/MS). Meanwhile, combining macro-genomic and metabolomic techniques to explore the association between microplastics and host microbiota and metabolic profiles, and to reveal the potential effects of microplastics on gastric cancer incidence and development will provide new insights into the relationship between microplastic contamination and gastric cancer, as well as an important scientific basis for future public health strategies and cancer prevention and control measures.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * age ≥18 years old; * diagnosed with gastric cancer by pathology before surgery and not receiving chemotherapy, radiotherapy or immunotherapy; * no history of other gastrointestinal diseases; * complete clinical data and basic information; * willing to participate in this study and sign an informed consent form. Exclusion Criteria: * Patients receiving neoadjuvant radiotherapy or chemotherapy; * patients with other malignant tumors other than gastric cancer; * patients with incomplete or unclear pathological data; * individuals who are not willing to participate in the study.

Primary outcome measure(s)

  • Types of microplastics in gastric cancerous and paracancerous tissues (categorical measure) — The date of microplastics testing, assessed up to 1 week after surgery.
    Polymer types of microplastics in gastric tissues Time Frame: Intraoperative sampling Measuring tool: μ-FTIR spectroscopy Unit: Categorical classification (e.g., polyethylene, polypropylene, etc.)

Trial sites (1)

FacilityCityRegionStatus
The First Affiliated Hospital of Chongqing Medical University Chongqing Chongqing Municipality

More Dong Peng trials in China

Microplastics in Paraneoplastic and Intratumoral for Colorectal Cancer Active, not recruiting
the Effect of Environmental Factors on Colorectal Cancer Based on Macrogenomes Active, not recruiting
The Effect of Environmental Factors on Gastric Cancer Based on Macrogenome Active, not recruiting
Impact of Pre- and Post-operative Serum Metabolome Dynamics in Colorectal Resection Outcomes Active, not recruiting
Impact of Environmental Factors and Metabolomics on Colorectal Cancer. Active, not recruiting

Other trials for the same condition

The Effect of Environmental Factors on Gastric Cancer Based on Macrogenome Active, not recruiting
Robotic Gastrectomy for Locally Advanced Gastric Cancer After Neoadjuvant Therapy Recruiting
Predictive Value of Air Pollution and Metabolomics for Gastric Cancer. Active, not recruiting
Analysis of Lymph Node Metastasis and Tumor Deposit in the Short Gastric Mesentery Following Total Gastrectomy for Gastric Cancer Recruiting
QL1706 Combined With SOX Used in Theperioperative Treatment Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06856382 on ClinicalTrials.gov ↗ ← All trials in China