EIT-guided Phigh settings during APRV: The Phigh level selected for the patients in the Intervention group was the intercept point of cumulated collapse and overdistension percentage curves, providing the best compromise between collapsed and overdistended lung.
Study summary
This study aims to investigate the effects of EIT-guided and Pplat-guided Phigh settings on regional ventilation and perfusion in ARDS patients during APRV, while also examining the impact of different Phigh settings on gas exchange, respiratory mechanics, and hemodynamics.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Diagnosed with ARDS according to the 2023 global new definition of ARDS.
* Age ≥ 18 years.
Exclusion Criteria:
* Severe chronic obstructive pulmonary disease, severe asthma, pulmonary bullae, pneumothorax, subcutaneous emphysema, mediastinal emphysema, etc. · Contraindications for EIT, such as chest wound dressing, pacemaker implantation, defibrillator use, etc.
* Pulmonary interstitial disease.
* Uncorrected shock of various types.
* Intracranial hypertension.
* Pregnant and postpartum women.
Primary outcome measure(s)
The effects of Phigh guided by different methods on regional lung ventilation assessed by EIT — 1 Hour Post-Intervention
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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