Iodine excess: Iodine excess areas: water iodine ≥100μg/L; or urinary iodine concentration (median urinary iodine levels in children aged 8-10 years old)≥300μg/L
Iodine suitable: Iodine suitable areas：water iodine ≥40μg/L and ≤100μg/L; or urinary iodine concentration(median urinary iodine levels in children aged 8-10 years old) 100-199μg/L.
Study summary
The effect of iodine nutritional status on thyroid cancer has been controversial for many years. We designed a prospective cohort study that recruiting patients in different iodine areas who underwent thyroid cancer surgery in branch hospitals from 2012 to 2019，and follow up their clinical outcomes. We aimed to analyse the relationship between regional iodine nutrition level and pathological types, clinical features, and prognosis of thyroid cancer.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
1. Age range: 18\~65 years old, gender not limited;
2. Living in the selected region for at least 5 years;
3. Patients who underwent thyroid surgery at various research centers were pathologically diagnosed with thyroid cancer;
4. The clinical data （general information、surgical scope 、pathological report、utrasonic report, etc ）of the case is complete.
Exclusion Criteria:
1. Diagnosed as other types of cancer or thyroid metastatic cancer;
2. There are serious comorbidities such as heart, liver, and kidney diseases present;
3. Unable to follow up on prognostic information.
Primary outcome measure(s)
Number of participants with recurrence — from enrollment to the final follow-up at 5 years Recurrence: diagnosed as the same type of thyroid cancer again by pathology
Number of participants with distant metastasis — from enrollment to the final follow-up at 5 years Distant metastasis: Pathological confirmed thyroid cancer occurring outside the thyroid gland
All-cause mortality — from enrollment to the final follow-up at 5 years The ratio of the total number of deaths caused by various reasons during the research period to the number of participants
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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