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Clinical Trials in China / NCT06066775
Recruiting Observational

Endocrine Glucose & Lipids Metabolism and Brain Aging: a Longitudinal Study

NCT06066775 · tracked via the Priya Life Science China tracker
Sponsor
Shandong Provincial Hospital
Phase
Observational
Started
2023-07-04
Last updated
2023-10-06

Condition(s) studied

Brain Aging Related Conditions

Investigational drug(s) / intervention(s)

Observation study without intervention

Observation study without intervention: Observation study without intervention

Study summary

With aging, brain aging leads to a general decline in cognitive ability, and the prevalence of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) increases. The prevalence of abnormal glucose and lipid metabolism also increased with age. The imbalance of glucose and lipid metabolism is closely related to brain aging related conditions and diseases, and the relationship between glucose and lipid metabolism and brain aging has not been fully elucidated.

Phase 1: Baseline investigation (community-based survey) Aims: To investigate whether glucose and lipids are the risk factors for brain aging-related conditions, such as mild cognitive impairment.

Subjects and Methods: A community-based survey will be carried out in 10000 natural population aged \>=50 years selected from 10-12 communities stratified according to geographic regions (Ciyao, Huafeng, Dongzhuang, Heshan, Geshi, Jiangji, Gangcheng, Fushan, Dongshu, Sidian, Baxianqiao, and Xiangyin, etc) in Ningyang County, Taian City, Shandong Province. A comprehensive examination including questionnaire (including the MMSE and ADL evaluation for the participants), anthropometric measurements, biochemical analysis will be performed in each study participant. In particular, the investigators randomly selected 1000-2000 participants performing MRI of the brain to evaluate the brain aging related conditions.

Phase 2: Cohort follow-up Aims : To examine glucose and lipids metabolism levels and their changes that modify the risk of brain aging-related conditions.

Subjects and Methods: To recruit and follow all 10000 participants for at least 3-5 years. In particular, all 1000-2000 participants with the baseline MRI examination will perform the MRI examination again for the follow-up.

Eligibility

Sex
ALL
Min age
50 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: 1. Age \>= 50 years old; 2. Gender: males and females; 3. Provide written informed consent; 4. Satisfactory compliance. Exclusion Criteria: 1. Pregnant or lactating women 2. No history of addiction or neurological, psychiatric, or systemic diseases known to affect cognitive function, including head trauma, subdural hematoma, current depression, and epilepsy 3. Any other condition or major systemic diseases that the investigator feels would interfere with trial participation or evaluation of results.

Primary outcome measure(s)

  • number of participants who develop brain aging-related conditions during follow-up — 5 years

Trial sites (1)

FacilityCityRegionStatus
Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06066775 on ClinicalTrials.gov ↗ ← All trials in China