Clinical Trials in China / NCT06579677
Recruiting
Observational
PRospective Observation on CErebral microvaScular Structure and Function
NCT06579677 · tracked via the Priya Life Science China tracker
Condition(s) studied
Cerebral Microvascular DysfunctionCerebral Small Vessel DiseasesCognitive DysfunctionCerebrovascular DisordersCardiovascular DiseasesPopulation
Investigational drug(s) / intervention(s)
Without any intervention
Without any intervention: No interventions will be performed.
Study summary
This is a population-based prospective cohort study, aiming to assess the prevalence, distributional characteristics, and dynamic change of cerebral small vessel dysfunction in a Chinese community population using advanced vascular imaging techniques; meanwhile to investigate the effect of vascular risk factors on cerebral small vessel dysfunction, cardiovascular and cerebrovascular diseases, cognitive dysfunction, and mortality.
Eligibility
Inclusion Criteria:
1. Community-dwelling adults aged 50-75 years;
2. Registered Beijing household residents or residents who can be followed up stably in their own communities for a long period;
3. Subjects with written informed consents.
Exclusion Criteria:
1. Residents with moderate to severe disabilities (MRS ≥3), mental illness, stroke, dementia, and other serious neurological disorders (e.g., encephalitis, Parkinson's disease, epilepsy, brain tumors, and rare genetic diseases of the nervous system);
2. Life expectancy of ≤4 years due to serious diseases such as end-stage cancer;
3. Contraindications to magnetic resonance imaging such as implanted devices (e.g., pacemakers, defibrillators, and others);
4. Residents who are participating in other studies.
Primary outcome measure(s)
- Cerebral small vessel disease — 2024-09 to 2032-09
Cerebral small vessel disease will be evaluated using 3.0 T MRI based on imaging markers of asymptomatic cerebral infarction, cerebral microbleeds, lacunar, white matter hyperintensity, enlarged perivascular space, and cerebral atrophy. - Neurovascular coupling — 2024-09 to 2032-09
Neurovascular coupling is one of cerebral small vessel function indicators and will be measured by 3.0 T MRI. - Cerebral perfusion — 2024-09 to 2032-09
Cerebral perfusion is one of cerebral small vessel function indicators and will be measured by 3.0 T MRI. - Cerebral autoregulation — 2024-09 to 2032-09
Cerebral autoregulation is one of cerebral small vessel function indicators and will be measured by transcranial Doppler ultrasonography. - Cerebral resting blood flow — 2024-09 to 2032-09
Cerebral resting blood flow is one of cerebral small vessel function indicators and will be measured by transcranial Doppler ultrasonography.
Trial sites (2)
| Facility | City | Region | Status |
|---|---|---|---|
| Beijing Tiantan Hospital | Beijing | Beijing Municipality | Not Yet Recruiting |
| Beijing Daxing District People Hospital | Beijing | Beijing Municipality | Recruiting |
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Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06579677 on ClinicalTrials.gov ↗ ← All trials in China