Cerebral Microvascular DysfunctionCerebral Small Vessel DiseasesCognitive DysfunctionCerebrovascular DisordersCardiovascular DiseasesPopulation
Investigational drug(s) / intervention(s)
Without any intervention
Without any intervention: No interventions will be performed.
Study summary
This is a population-based prospective cohort study, aiming to assess the prevalence, distributional characteristics, and dynamic change of cerebral small vessel dysfunction in a Chinese community population using advanced vascular imaging techniques; meanwhile to investigate the effect of vascular risk factors on cerebral small vessel dysfunction, cardiovascular and cerebrovascular diseases, cognitive dysfunction, and mortality.
Eligibility
Sex
ALL
Min age
50 Years
Max age
75 Years
Healthy volunteers
Accepted
Inclusion Criteria:
1. Community-dwelling adults aged 50-75 years;
2. Registered Beijing household residents or residents who can be followed up stably in their own communities for a long period;
3. Subjects with written informed consents.
Exclusion Criteria:
1. Residents with moderate to severe disabilities (MRS ≥3), mental illness, stroke, dementia, and other serious neurological disorders (e.g., encephalitis, Parkinson's disease, epilepsy, brain tumors, and rare genetic diseases of the nervous system);
2. Life expectancy of ≤4 years due to serious diseases such as end-stage cancer;
3. Contraindications to magnetic resonance imaging such as implanted devices (e.g., pacemakers, defibrillators, and others);
4. Residents who are participating in other studies.
Primary outcome measure(s)
Cerebral small vessel disease — 2024-09 to 2032-09 Cerebral small vessel disease will be evaluated using 3.0 T MRI based on imaging markers of asymptomatic cerebral infarction, cerebral microbleeds, lacunar, white matter hyperintensity, enlarged perivascular space, and cerebral atrophy.
Neurovascular coupling — 2024-09 to 2032-09 Neurovascular coupling is one of cerebral small vessel function indicators and will be measured by 3.0 T MRI.
Cerebral perfusion — 2024-09 to 2032-09 Cerebral perfusion is one of cerebral small vessel function indicators and will be measured by 3.0 T MRI.
Cerebral autoregulation — 2024-09 to 2032-09 Cerebral autoregulation is one of cerebral small vessel function indicators and will be measured by transcranial Doppler ultrasonography.
Cerebral resting blood flow — 2024-09 to 2032-09 Cerebral resting blood flow is one of cerebral small vessel function indicators and will be measured by transcranial Doppler ultrasonography.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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