Clinical Trials in China / NCT06367946
Recruiting
Observational
Mechanism Study of Ventilator-Induced Lung Injury in Elderly People.
NCT06367946 · tracked via the Priya Life Science China tracker
Condition(s) studied
Ventilator-Induced Lung Injury
Investigational drug(s) / intervention(s)
mechanical ventilation
mechanical ventilation: Mechanical ventilation is machine-delivered flow of gases to both oxygenate and ventilate a patient who is unable to maintain physiological gas exchange.
Study summary
1. We collect lung tissues from patients with different ages and confirm that KLK8 expression is positively correlated with age.
2. We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelial/epithelial damage, age and duration of mechanical ventilation.
Eligibility
Inclusion Criteria:
1. Lung tissues from patients with different ages:
Patients undergoing elective general anesthesia surgery; Patients undergoing partial lung resection with mechanical ventilation; American Society of Anesthesiology (ASA) grade 2-3;
2. Peripheral blood from patients with different ages and duration of mechanical ventilation:
Patients undergoing elective general anesthesia surgery with mechanical ventilation; ASA grade 2-3;
Exclusion Criteria:
1. Lung tissues from patients with different ages:
Patients with chronic lung diseases (asthma, chronic obstructive pulmonary disease (COPD), pulmonary heart disease, etc.); Patients with human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.
2. Peripheral blood from patients with different ages and duration of mechanical ventilation:
Patients with chronic lung diseases (asthma, COPD, pulmonary heart disease, etc.); Smoking patients; Patients with hypertension/diabetes/coronary heart disease; Patients with HIV, HBV, HCV, HDV, or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.
Primary outcome measure(s)
- KLK8 concentration of lung tissue — 2023.7.1-2024.7.1
The concentration of KLK8 in lung tissue is determined by ELISA. - Endothelial/epithelial damage index concentration in peripheral blood — 2024.5.1-2024.8.1
The concentration of endothelial/epithelial damage index in lung tissue is determined by ELISA.
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Shanghai Xinhua hospital | Shanghai | China | Recruiting |
More Xinhua Hospital, Shanghai Jiao Tong University School of Medicine trials in China
Other trials for the same condition
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06367946 on ClinicalTrials.gov ↗ ← All trials in China