Efficacy and Safety of Oliceridine for Moderate to Severe Acute Pain After Orthopedic Surgery

Condition(s) studied

Investigational drug(s) / intervention(s)

Low dose oxelidine group: Analgesic dose

High dose oxelidine group: Analgesic dose

Hydromorphone group: Analgesic dose

Study summary

The goal of this clinical trial\] is to further explore the effectiveness and safety of oxelidine in the treatment of moderate to severe acute pain after orthopedic surgery. The main question it aims to answer is: Pain management after orthopaedic surgery provides more effective and safe drug options, provides new options for clinical treatment, and provides a scientific basis for clinical practice.

Participants will be asked to pain score in the different time, treatments they'll be given and use optimal drug. Researchers will compare analgesic effect of oxelidine of different dose.

Eligibility

Primary outcome measure(s)

• Pain score at rest 0-72 hours after surgery — 1 h (hour), 6 h,12 h,18 h,24 h,32 h,40 h,48 h,60 h,72 h (hours) after surgery
  Patients' pain scores at rest were recorded from 0-72 hours after surgery.

Trial sites (1)

More The Fourth Affiliated Hospital of Zhejiang University School of Medicine trials in China

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