Wenzhou Gestational Diabetes Cohort

Condition(s) studied

Investigational drug(s) / intervention(s)

Standardized breakfast: Participants will be provided with a standardized breakfast on a morning of the days they wear a continuous glucose monitoring (CGM) device.

Standardized snack: Participants will be provided with a standardized snack 2 hour after they have the standardized breakfast.

Standardized lunch: Participants will be provided with a standardized lunch 2 h after they have the standardized snack.

Study summary

The Wenzhou Gestational Diabetes Cohort (WGDC) is a prospective cohort study among women with gestational diabetes mellitus (GDM) during pregnancy and their offspring living in Wenzhou, China. The primary aim of this cohort is to characterize the continuous blood glucose response to dietary intake and physical activity among pregnant women with GDM over 2 weeks, and to facilitate the development of personalized nutritional/lifestyle recommendation among these patients. Another aim of the WGDC is to investigate the association of dietary and physical activity together with continuous glucose change during pregnancy on the adverse birth outcomes including preterm birth, macrosomia and large-for-gestational-age birth. The secondary aim is to investigate the prospective associations of diet, physical activity and continuous glucose change over 2 weeks among the patients with long-term metabolic health of the women and their offspring.

Eligibility

Primary outcome measure(s)

• Continuous blood glucose change over 2 weeks — two weeks after enrollment
  Glucose levels are assessed by continuous glucose monitoring over 2 weeks.
• Adverse birth outcomes — 9-12 weeks after enrollment
  Number of participants with adverse birth outcomes, such as, preterm birth, macrosomia and neonatal hypoglycemia.

Trial sites (1)

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