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Clinical Trials in China / NCT05459727
Starting soon Not applicable

Effects of Non-surgical Periodontal Therapy on Cardiovascular Risk

NCT05459727 · tracked via the Priya Life Science China tracker
Sponsor
Nanfang Hospital, Southern Medical University
Phase
Not applicable
Started
2022-08-01
Last updated
2022-07-15

Condition(s) studied

Cardiovascular DiseasesPeriodontitis

Investigational drug(s) / intervention(s)

Non-surgical periodontal therapyControl periodontal treatment

Non-surgical periodontal therapy: Non-surgical periodontal therapy includes basic oral hygiene instructions and full-mouth subgingival scaling and root planing under local anesthesia.

Control periodontal treatment: Control periodontal treatment includes basic oral hygiene instructions and full-mouth supragingival ultrasonic scaling.

Study summary

This study is to evaluate whether non-surgical periodontal therapy can help to control the cardiovascular risk among patients with moderate/severe periodontitis and at risk of cardiovascular disease.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Age ≥ 18 years; * At risk of cardiovascular disease (defined as "Framingham Score" predicted 10-year risk of cardiovascular disease ≥ 20%); * Moderate//severe periodontitis; Exclusion Criteria: * Cardiovascular diseases at baseline (coronary heart disease, stroke and peripheral artery disease); * Received periodontal treatment within the past 6 months; * Pregnant or lactating females; * Non residents of Guangzhou and its surrounding cities or expected to leave Guangzhou or its surrounding cities within 1 year; * Malignant tumors or other end-stage diseases with life expectancy less than 1 year; * End-stage renal disease; * Patients with high bleeding risk, high blood pressures or other situations that make them unable to receive interventions; * Refuse to provide informed consent;

Primary outcome measure(s)

  • Change from Baseline Cardiovascular risk (Framingham risk score (FRS)) at 1 year. — Baseline; 1 year
    Cardiovascular risk is assessed by "Framingham risk score (FRS)". (Circulation, 2008,117(6): 743-753.) Generally, the "Framingham risk score (FRS)" ranges from -4 to 33 for men and -5 to 33 for women. A higher "Framingham risk score (FRS)" means a higher risk of developing cardiovascular disease.

Trial sites (2)

FacilityCityRegionStatus
Stomatological Hospital, Southern Medical University Guangzhou Guangdong
Nanfang Hospital, Southern Medical University Guangzhou Guangdong

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Other trials for the same condition

Intensive Treatment on Periodontitis in Aortic Stenosis Recruiting
Factors Associated With Posttransplant Cardiac Outcomes Recruiting
Cardiovascular Risk Assessment and Dynamic Monitoring-based Prevention Trial Recruiting
Lifestyle and Dietary Pattern in Relation to Precursor Lesions of Colorectal Cancer and Cardiometabolic Diseases Active, not recruiting
Oral Health Outcomes With Amphion Mouthwash as an Adjunct to Non-Surgical Periodontal Therapy Starting soon
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05459727 on ClinicalTrials.gov ↗ ← All trials in China