Non-surgical periodontal therapy: Non-surgical periodontal therapy includes basic oral hygiene instructions and full-mouth subgingival scaling and root planing under local anesthesia.
Control periodontal treatment: Control periodontal treatment includes basic oral hygiene instructions and full-mouth supragingival ultrasonic scaling.
Study summary
This study is to evaluate whether non-surgical periodontal therapy can help to control the cardiovascular risk among patients with moderate/severe periodontitis and at risk of cardiovascular disease.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Age ≥ 18 years;
* At risk of cardiovascular disease (defined as "Framingham Score" predicted 10-year risk of cardiovascular disease ≥ 20%);
* Moderate//severe periodontitis;
Exclusion Criteria:
* Cardiovascular diseases at baseline (coronary heart disease, stroke and peripheral artery disease);
* Received periodontal treatment within the past 6 months;
* Pregnant or lactating females;
* Non residents of Guangzhou and its surrounding cities or expected to leave Guangzhou or its surrounding cities within 1 year;
* Malignant tumors or other end-stage diseases with life expectancy less than 1 year;
* End-stage renal disease;
* Patients with high bleeding risk, high blood pressures or other situations that make them unable to receive interventions;
* Refuse to provide informed consent;
Primary outcome measure(s)
Change from Baseline Cardiovascular risk (Framingham risk score (FRS)) at 1 year. — Baseline; 1 year Cardiovascular risk is assessed by "Framingham risk score (FRS)". (Circulation, 2008,117(6): 743-753.) Generally, the "Framingham risk score (FRS)" ranges from -4 to 33 for men and -5 to 33 for women. A higher "Framingham risk score (FRS)" means a higher risk of developing cardiovascular disease.
Trial sites (2)
Facility
City
Region
Status
Stomatological Hospital, Southern Medical University
Guangzhou
Guangdong
Nanfang Hospital, Southern Medical University
Guangzhou
Guangdong
More Nanfang Hospital, Southern Medical University trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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