Bronchial Ablation for Treatment of Asthma (BATA) Trial

Inclusion Criteria: * Subject is an adult between the ages of 18 to 65 years; * Diagnosed with asthma who required regular asthma maintenance medication in the past 6 months as follows: ICS ≥1000 μg/day beclomethasone or equivalent and LABA ≥1000μg /day salmeterol or equivalent. Other medications were allowed, including leukotriene modifiers, and Oral Corticosteroids (OCS) ≤ 10mg/day. * At least two days of asthma symptoms during 4-weeks of the baseline period. * Pre-bronchodilator Forced Expiratory Volume in one second (FEV1) of greater than or equal to 45% of predicted. * Non-smoker (less than 10 pack per year) last for 1 year or greater. * Baseline AQLQ Score less than or equal to 6.25 * Willingness and ability to comply with the outpatient follow-up. Exclusion Criteria: * Pre-bronchodilator Forced Expiratory Volume in one second (FEV1) of less than 45% of predicted. * 3 or more hospitalizations for exacerbations of asthma in the past 12 months; * More than 3 lower respiratory tract infections requiring antibiotics in the past 12 months * More than 4 of oral steroid use for exacerbations of asthma in the past 12 months * Chronic sinusitis * Uncontrolled gastroesophageal reflux disease, defined as a significant increase in treatment over the past 6 weeks * Sensitivity to medications required to perform bronchoscopy (such as lidocaine and benzodiazepines) * Use of an implantable electrical stimulation device, such as a pacemaker, a cardiac defibrillator or a deep nerve or deep brain stimulator; * Severe emphysema caused by chronic obstructive pulmonary disease (COPD). * Use of systemic immunosuppressants, beta adrenergic blockers, or anticoagulants. * History of fatal asthma. * Uncontrolled obstructive sleep apnea * Intubation or admission to the ICU for asthma exacerbations within 2 years prior to treatment * Hemorrhagic or malignant tumors or Coagulopathy. * Lower bronchial stenosis or distal complete atelectasis or other severe bronchial and pulmonary lesions, as Thoracic spiral CT showed * Poor compliance judged by the investigator, or other medical conditions that are not suitable for the study * Related contraindications for bronchoscopy * Pregnant, lactating women, or patients with a birth plan in the next year * Previously undergone bronchial thermoplasty