Effort of Breathing and Dyssynchrony Burden During Assisted Ventilation in Paediatric Patients

Condition(s) studied

Investigational drug(s) / intervention(s)

Pressure Control Mode: In pressure control mode every breath is controlled by the ventilator, including when the breaths are delivered. This mode is typically used when patients are sedated and unable to breathe on their own.

Pressure Support Mode: In pressure support mode every breath is initiated and controlled by the patient. This mode is used when patients are awake enough to take all breaths on their own.

Study summary

The goal of this trial is to learn if one mode of mechanical ventilation (i.e. machine to help with breathing) is better than another in children who need help from a machine to breathe. The main questions it aims to answer are:

* How hard do children need to work to breathe when they are using different types of modes of mechanical ventilation?
* Evaluate which mode of mechanical ventilation performs better when the patient is clinically awake enough to start breaths

Eligibility

Primary outcome measure(s)

• Average effort of breathing — Analyses will be performed on patient-level summaries averaged over the last 25 minutes of each ventilation mode (SIMV, PCV, PSV).
  Muscular pressure or Pmus (calculated from DPes and using the chest wall compliance of the participant and measured by specific software \[FluxReview\]) during the assisted modes. For each patient, the change in Pmus from SIMV to PSV and from SIMV to PCV will be computed. The within-patient difference between these changes will be summarized in terms of median and interquartile range, and assessed using a Wilcoxon signed-rank test.

Trial sites (1)

More The Hospital for Sick Children trials in Canada

Other trials for the same condition