Frequency and Severity of Respiratory Acidosis During One-lung Ventilation, a Retrospective Pilot Study to Compare Clinician Settings and Those Proposed by the VentilO Application

Condition(s) studied

Investigational drug(s) / intervention(s)

one lung ventilation: Arterial blood gases during one lung ventilation

Study summary

One-lung ventilation is a mechanical ventilation method frequently used during several thoracic surgeries. One-lung ventilation requires the use of protective ventilation to limit ventilator-induced injury and reduce postoperative respiratory complications. Protective ventilation during one-lung ventilation is specific since tidal volumes are applied by definition to one lung, and it is recommended to use lower tidal volumes, down to 4 ml/kg of ideal body weight. This approach requires individualized ventilation parameters, which differs from the conventional or two-lung ventilation, and there are no clear recommendations regarding respiratory rate adjustment to ensure adequate gas exchange.

Eligibility

Primary outcome measure(s)

• Respiratory acidosis — 20 minutes after initiation of one lung ventilation after lung isolation
  The frequency of respiratory acidosis on arterial blood gases after 20 minutes of mechanical ventilation (pH \< 7.35 and PaCO2 \> 45mmHg) measured by arterial blood gases

Trial sites (1)

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