🇮🇪Ireland
16°C Partly Cloudy · Dublin
Live Updates
--:--:-- IST
Contributor sign in
Latest
Clinical Trials in Canada / NCT05705531
Recruiting Observational

A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatment for Hodgkin Lymphoma

NCT05705531 · tracked via the Priya Life Science Canada tracker
Phase
Observational
Started
2023-08-18
Last updated
2026-08-25

Condition(s) studied

Cardiovascular DisorderClassic Hodgkin LymphomaClonal Hematopoiesis

Investigational drug(s) / intervention(s)

Archive Sample RetrievalBiospecimen CollectionElectronic Health Record ReviewMagnetic Resonance ImagingSurvey Administration

Archive Sample Retrieval: Undergo collection of archived blood sample

Biospecimen Collection: Undergo blood sample collection

Electronic Health Record Review: Undergo medical record abstraction

Magnetic Resonance Imaging: Undergo MRI

Survey Administration: Complete surveys

Study summary

This study assesses how blood cell growth patterns (clonal hematopoiesis) relate to heart health or cardiovascular disease (CVD) after treatment in patients with Hodgkin lymphoma. In some patients, cancer treatment at a young age may lead to later complications, including problems with heart health. Checking for blood cell growth patterns called therapy-related clonal hematopoiesis (t-CH) can help predict who might be at risk for heart health problems after Hodgkin lymphoma treatment. If doctors know who may be at greater risk for developing later heart complications, then they can more closely monitor those patients to prevent or detect heart complications early.

Eligibility

Sex
ALL
Min age
7 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Patient must be \>= 7 years of age at the time of enrollment (age to perform an MRI without sedation). * History of pathologically confirmed classical Hodgkin Lymphoma (cHL) initially diagnosed when the patient was \>= 2 and \< 22 years of age. * As part of frontline therapy for cHL, the patient must have received a cumulative doxorubicin equivalent anthracycline dose of ≥ 200 mg/m\^2 as estimated in doxorubicin isotoxic equivalents dose conversion calculation. * Note: History of COG therapeutic trial participation is not required. Institutional records (e.g., clinic note, treatment summary, chemotherapy roadmap) can be used as reference documentation of receipt of anthracycline dose. * All systemic cancer treatment must have been completed ≥ 2 years prior to study enrollment. * Not known to have had a primary event (relapse/second malignancy/death). * Note: Subjects treated at another institution are eligible if they are now being followed at the current COG institution, if the study procedures can be performed and the data accessible by a COG institution where the study is open. * Patient must have access to cardiac MRI at the enrolling institution and must be able to complete cardiac MRI without sedation. Exclusion Criteria: * Medical contraindication to undergoing a non-contrast cardiac MRI. * Patients with nodular lymphocyte-predominant HL. * Received cancer therapy in addition to that for primary Hodgkin Disease (e.g., for disease progression or recurrence, or subsequent malignant neoplasm). * History of CTCAE grade 3 or higher cardiovascular disease or condition known to exist prior to the patient's initial diagnosis of cHL. * Note: exceptions are made for congenital conditions considered fully resolved by surgery and chronic conditions such as hypertension or hypercholesterolemia that are managed with medical intervention. * History of an immunodeficiency that existed prior to cHL diagnosis, such as primary immunodeficiency syndromes, organ transplant recipients and conditions requiring systemic immunosuppressive agents.

Primary outcome measure(s)

Trial sites (36)

FacilityCityRegionStatus
USA Health Strada Patient Care Center Mobile Alabama Recruiting
Phoenix Childrens Hospital Phoenix Arizona Recruiting
City of Hope Comprehensive Cancer Center Duarte California Recruiting
Valley Children's Hospital Madera California Recruiting
Connecticut Children's Medical Center Hartford Connecticut Recruiting
Yale University New Haven Connecticut Recruiting
Alfred I duPont Hospital for Children Wilmington Delaware Recruiting
Golisano Children's Hospital of Southwest Florida Fort Myers Florida Recruiting
Nemours Children's Clinic-Jacksonville Jacksonville Florida Recruiting
Arnold Palmer Hospital for Children Orlando Florida Recruiting
Nemours Children's Hospital Orlando Florida Recruiting
Nemours Children's Clinic - Pensacola Pensacola Florida Recruiting
Saint Joseph's Hospital/Children's Hospital-Tampa Tampa Florida Recruiting
Children's Healthcare of Atlanta - Arthur M Blank Hospital Atlanta Georgia Recruiting
Southern Illinois University School of Medicine Springfield Illinois Recruiting
University of Maryland/Greenebaum Cancer Center Baltimore Maryland Recruiting
C S Mott Children's Hospital Ann Arbor Michigan Recruiting
Children's Hospitals and Clinics of Minnesota - Minneapolis Minneapolis Minnesota Recruiting
Washington University School of Medicine St Louis Missouri Recruiting
Hackensack University Medical Center Hackensack New Jersey Recruiting
Albany Medical Center Albany New York Recruiting
Roswell Park Cancer Institute Buffalo New York Recruiting
Wake Forest University Health Sciences Winston-Salem North Carolina Recruiting
Cincinnati Children's Hospital Medical Center Cincinnati Ohio Recruiting
Nationwide Children's Hospital Columbus Ohio Recruiting
Oregon Health and Science University Portland Oregon Recruiting
Children's Hospital of Philadelphia Philadelphia Pennsylvania Recruiting
Children's Hospital of Pittsburgh of UPMC Pittsburgh Pennsylvania Recruiting
East Tennessee Childrens Hospital Knoxville Tennessee Recruiting
Cook Children's Medical Center Fort Worth Texas Recruiting
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston Texas Recruiting
Children's Hospital of San Antonio San Antonio Texas Recruiting
University of Virginia Cancer Center Charlottesville Virginia Recruiting
Seattle Children's Hospital Seattle Washington Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin Recruiting
Hospital for Sick Children Toronto Ontario Suspended

More Children's Oncology Group trials in Canada

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05705531 on ClinicalTrials.gov ↗ ← All trials in Canada