SCFE Longitudinal International Prospective Registry

Condition(s) studied

Investigational drug(s) / intervention(s)

Observational: All groups will undergo observational data collection. No interventions will be made to patient care.

Study summary

Slipped Capital Femoral Epiphysis (SCFE) is the most common disorder of the adolescent hip and diagnosis and treatment of SCFE remain areas of controversy and investigation. The current issues relating to diagnosis stem from an inability to diagnose the condition early on, resulting in increased morbidity. Once diagnosed, there are multiple different options for surgical treatment, including in-situ pinning, and the Modified Dunn procedure. Research is ongoing to determine the parameters that should be considered when selecting a procedure to ensure an ideal outcome. In particular, there is a focus on investigating which treatment method may result in lower incidence of avascular necrosis of the femoral head and femoroacetabular impingement (FAI), two significant long term concerns associated with SCFE. Despite myriad published studies on SCFE, very few are prospective and most lack sufficient patient numbers for clinically meaningful comparative analysis. The aim of this study is to develop a multi-center, international prospective registry of patients with SCFE to facilitate the comprehensive examination of clinical, functional and radiographic outcomes of each treatment, in relation to specific parameters determined prior to intervention. The general registry will serve as a hypothesis-generating database of prospectively collected outcomes. In turn, this will facilitate the development of targeted, hypothesis-testing randomized controlled trials and observational studies that can be housed within the larger registry.

Eligibility

Primary outcome measure(s)

• Development of a multi-centre, general, prospective SCFE registry, with follow-up to skeletal maturity — Until study completion in 2028
• Comparison of the clinical, functional, and radiographic parameters related to SCFE in the context of treatment outcomes — Until study completion in 2028
• Examination of the long-term outcome of prophylactically pinning the contralateral hip, specifically in regards to development of avascular necrosis — Until study completion in 2028
• Determination of whether prophylactic fixation allows for preservation of hip morphology and function in the short and long term — Until study completion in 2028
• Comparative analysis of surgical treatment outcomes, with particular regard to complications (avascular necrosis, femoroacetabular impingement (FAI), secondary surgeries) — Until study completion in 2028
• Comparison of mild SCFE treatment with or without acute FAI treatment in regard to complication and short-term outcomes — Until study completion in 2028
• Examination of timelines and results of diagnostic tests leading to the diagnosis of SCFE — Until study completion in 2028
• Determination of the timeline for patients to return to full weight-bearing following treatment and to assess the level to which they return to activity — Until study completion in 2028

Trial sites (1)

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