Clinical Outcomes in Pediatric Obsessive-Compulsive Disorder

NCT01635569 · tracked via the Priya Life Science Canada tracker

Sponsor

University of British Columbia

Phase

Not applicable

Started

2012-10-01

Last updated

2023-05-12

Condition(s) studied

Obsessive-compulsive Disorder

Investigational drug(s) / intervention(s)

Group-based family cognitive-behavioural therapyWaitlist

Group-based family cognitive-behavioural therapy: Baseline and post-12 sessions

Waitlist: Baseline and post-12 sessions

Study summary

Obsessive-Compulsive Disorder (OCD) is a common neuropsychiatric illness beginning in childhood. Effective OCD treatments include cognitive-behaviour therapy (CBT) and medications but access to treatment is difficult and does not systematically include parents. The investigators will evaluate clinical and neural effects of Group-based Family CBT (GF-CBT), via a case-control study including: Group 1 - OCD cases receiving GF-CBT (N=90); Group 2 - OCD waitlist cases (N=90). Effects will be measured between baseline and completion of 12 GF-CBT sessions: comparing OCD severity and functioning changes between Groups 1 and 2.

Eligibility

Sex

ALL

Min age

5 Years

Max age

18 Years

Healthy volunteers

Inclusion Criteria: * Male or female, aged 5-18 years old * Ability of subject and parent to provide informed assent/consent * English-speaking * Current DSM IV-TR Axis I diagnosis of childhood-onset OCD; Moderate to severe OCD (CY-BOCS≥16/40) Exclusion Criteria: * Current diagnosis of bipolar disorder, psychosis, mental retardation or pervasive developmental disorder (e.g., autism), and current or past substance dependence/abuse

Primary outcome measure(s)

Children's Yale Brown Obsessive-Compulsive Scale (CY-BOCS) — Baseline, midpoint, completion of 12 GF-CBT sessions, one-month follow-up
CY-BOCS: gold-standard measure of OCD severity in pediatric OCD.

Trial sites (1)

Facility	City	Region	Status
BC Children's Hospital Research Institute	Vancouver	British Columbia	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT01635569 on ClinicalTrials.gov ↗ ← All trials in Canada