Photobiomodulation Effects on Blood Pressure and Vascular Function in Treated Hypertensive Patients

NCT07525310 · tracked via the Priya Life Science Brazil tracker

Sponsor

University of Nove de Julho

Phase

Not applicable

Started

2026-09-01

Last updated

2026-09-09

Condition(s) studied

Hypertension

Investigational drug(s) / intervention(s)

Vascular PhotobiomodulationSham Photobiomodulation

Vascular Photobiomodulation: Vascular photobiomodulation therapy applied over the radial artery using a red laser (wavelength: 660 nm; power: 100 mW).

Sham Photobiomodulation: Laser emission will be blocked to ensure no therapeutic effect

Study summary

This double-blind, randomized, sham-controlled clinical trial aims to evaluate the effects of vascular photobiomodulation on blood pressure and vascular function in hypertensive patients treated with losartan. A total of 80 patients using losartan (100 mg/day for at least two months) will be recruited and followed for 4 weeks. Participants will be randomly allocated to either an active photobiomodulation group or a sham control group.

Eligibility

Sex

ALL

Min age

18 Years

Max age

65 Years

Healthy volunteers

Inclusion Criteria: * Be taking losartan at a dose of 100 mg/day, either as monotherapy or in combination with other antihypertensive medications, administered in two divided doses, for a minimum of 2 months and a maximum of 24 months. * Present systolic blood pressure is less than or equal to 140 mmHg and diastolic less than or equal to 90 mmHg. * Not having used any other antihypertensive medication in the last 2 months. * Age between 18 and 65 years * If female, not pregnant * No cutaneous/subcutaneous lesions on both arms. * No musculoskeletal, rheumatic, cardiovascular, metabolic, neurological, oncological, immunological, hematological, psychiatric or cognitive diagnoses and that may be worsened by the intervention or prevent the correct application of FBM vascular. Exclusion Criteria: * Changes in medication status during the study

Primary outcome measure(s)

Change in Brachial Artery Vascular Function — Baseline and 4 weeks
Flow-mediated dilation (FMD, %) of the brachial artery assessed by Doppler ultrasound. Higher values indicate better endothelial function

Trial sites (1)

Facility	City	Region	Status
Raphael Dias	São Paulo	São Paulo	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07525310 on ClinicalTrials.gov ↗ ← All trials in Brazil