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Clinical Trials in Brazil / NCT06546137
Recruiting Observational

National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry

NCT06546137 · tracked via the Priya Life Science Brazil tracker
Sponsor
Hospital do Coracao
Phase
Observational
Started
2025-04-30
Last updated
2026-05-08

Condition(s) studied

Cardiomyopathy, HypertrophicCardiomyopathy, DilatedCardiomyopathy RestrictiveArrhythmogenic Right Ventricular DysplasiaNon-Compaction CardiomyopathyFamilial HypercholesterolemiaMarfan SyndromeEhlers-Danlos Syndrome, Vascular TypeLoeys-Dietz SyndromeLong QT SyndromeShort Qt SyndromeBrugada SyndromeCatecholaminergic Polymorphic Ventricular TachycardiaSudden Cardiac Death

Investigational drug(s) / intervention(s)

whole genome sequencing

whole genome sequencing: whole genome sequencing of genomic DNA extracted from buccal swab

Study summary

The goal of this observational study is to develop a registry of Brazilian patients with hereditary cardiovascular diseases, combining clinical and genomic data. The main questions it aims to answer are:

Which genes are most commonly affected? What is the frequency of these genetic alterations in our population? Participants will be interviewed in routine medical care visits and their DNA will be sequenced.

Eligibility

Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Clinical diagnosis of a hereditary cardiovascular disease according to current clinical guidelines * Agree to receive genetic counseling * Sign informed consent form * Provide the information required in the case report form Exclusion Criteria: * Signature absent from informed consent form * Inadequate buccal swab (sample may be collected twice)

Primary outcome measure(s)

Trial sites (27)

FacilityCityRegionStatus
Centro de Pesquisa Silvestre Santé Rio Branco Acre Recruiting
Centro de Pesquisas Clínicas Dr. Marco Mota Maceió Alagoas Recruiting
Hospital Universitário da Unifap Macapá Amapá Recruiting
Hospital de Messejana Dr. Carlos Alberto Studart Gomes Fortaleza Ceará Recruiting
Hospital Evangélico de Vila Velha Vila Velha Espírito Santo Recruiting
Hospital Universitário Professor Edgard Santos Salvador Estado de Bahia Recruiting
Hospital Ana Nery - HAN/SESAB Salvador Estado de Bahia Recruiting
Instituto de Cardiologia e Transplantes do Distrito Federal Brasília Federal District Recruiting
Hospital das Clínicas da Universidade Federal de Goiás - HC-UFG Goiânia Goiás Recruiting
Hospital Felicio Rocho - HFR Belo Horizonte Minas Gerais Recruiting
Liga Mineira de Ressuscitação Cardiopulmonar Belo Horizonte Minas Gerais Recruiting
Santa Casa de Misericórdia de Montes Claros Montes Claros Minas Gerais Recruiting
Health & Care Belém Pará Recruiting
Hospital Universitário Pedro Ernesto - UERJ Rio de Janeiro Rio de Janeiro Recruiting
Instituto de Puericultura e Pediatria Martagão Gesteira Rio de Janeiro Rio de Janeiro Recruiting
Hospital Universitário Clementino Fraga Filho - UFRJ Rio de Janeiro Rio de Janeiro Recruiting
Instituto Nacional de Cardiologia Rio de Janeiro Rio de Janeiro Recruiting
Hospital Universitário Onofre Lopes - UFRN Natal Rio Grande do Norte Recruiting
Hospital das Clínicas de Porto Alegre - UFRGS Porto Alegre Rio Grande do Sul Recruiting
Instituto de Cardiologia - Fundação Universitária de Cardiologia de Porto Alegre - IC-FUC Porto Alegre Rio Grande do Sul Recruiting
Instituto de Pesquisa e Ensino em Saúde - IPES Porto Velho Rondônia Recruiting
Centro Multidisciplinar de Ensino Especializado e Pesquisa Ltda Joinville Santa Catarina Recruiting
Hospital Universitário São Francisco na Providência de Deus, USF-SP Bragança Paulista São Paulo Recruiting
Instituto PENSI Consolação São Paulo Recruiting
Hospital Universitário da Universidade Federal de São Carlos São Carlos São Paulo Recruiting
Hospital do Coracao São Paulo São Paulo Recruiting
Universidade Federal do Tocantins Palmas Tocantins Recruiting

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Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis Recruiting
Physical Rehabilitation in Patients With Complex Congenital Heart Disease Active, not recruiting

Other trials for the same condition

AMEND-CRT: Mechanical Dyssynchrony as Selection Criterion for CRT Active, not recruiting
An Adapted Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Familial Hypercholesterolemia (DICA-FH) Active, not recruiting
Effect of an Aerobic Exercise Session on Cardiovascular and Autonomic Parameters of Adults With Hypertrophic Cardiomyopathy Active, not recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06546137 on ClinicalTrials.gov ↗ ← All trials in Brazil