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Clinical Trials in Brazil / NCT06438445
Recruiting Not applicable

Effects of Royal Jelly Supplementation in Chronic Kidney Disease

NCT06438445 · tracked via the Priya Life Science Brazil tracker
Sponsor
Universidade Federal Fluminense
Phase
Not applicable
Started
2024-07-30
Last updated
2026-05-18

Condition(s) studied

Kidney Failure, ChronicOxidative StressHemodialysis

Investigational drug(s) / intervention(s)

Real JellyPlacebo

Real Jelly: Participants will receive 500mg of royal jelly capsules per day for two months.

Placebo: Participants will receive 500mg of placebo capsules per day for two months.

Study summary

The objective of this study is to evaluate the effects of royal jelly on inflammation and cellular senescence in patients with chronic kidney disease (CKD) on hemodialysis (HD).

Eligibility

Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
No
Inclusion Criteria: * patients with CKD undergoing hemodialysis for more than 6 months * patients with arteriovenous fistula (AVF) as vascular access. Exclusion Criteria: * pregnant, * lactating, * smoker * patients using antibiotics and antioxidant supplements in the last three months * patients with autoimmune and infectious diseases, * patients with cancer, liver disease, and AIDS

Primary outcome measure(s)

  • Change in inflammatory biomarkers — 6 weeks
    Changes in the mRNA levels of Nrf2, Keap1, Bach1, NLPR3, NF-kB, HO-1, NQO1, p14, p16, p21 and p53 as well as VCAM, ICAM and E-selectin and TLR-4, TNFR and AhR receptors, which will be evaluated from peripheral blood mononuclear cells.

Trial sites (1)

FacilityCityRegionStatus
Denise Mafra Rio de Janeiro Rio de Janeiro Recruiting

More Universidade Federal Fluminense trials in Brazil

Effects of Jaboticaba (Plinia Cauliflora) Supplementation in Chronic Kidney Disease Patients Starting soon
Effects of Microencapsulated Propolis and Turmeric in Patients With Chronic Kidney Disease Active, not recruiting
Effects of Brazil Nut Supplementation in Patients With Chronic Kidney Disease Undergoing Conservative Treatment Active, not recruiting
Prospective Longitudinal Clinical Study for the Evaluation of Peri-implant Tissue and Osseointegration After Rehabilitation With Osseointegrated Implants Enrolling by invitation
Ginger in the Modulation of Inflammatory Cytokines and Oxidative Stress in Patients With Coronary Artery Disease Starting soon

Other trials for the same condition

Ginger in the Modulation of Inflammatory Cytokines and Oxidative Stress in Patients With Coronary Artery Disease Starting soon
Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE) Recruiting
Red Propolis Supplementation as a Strategy in Chronic Kidney Disease Recruiting
Effects of Royal Jelly and Propolis on Metabolomic Signatures, Inflammation, and Cardiovascular Risk in Patients With Coronary Artery Disease. Starting soon
EFFECTS OF A YERBA MATE EXTRACT IN REDUCING METABOLIC SYNDROME IN OVERWEIGHT INDIVIDUALS Enrolling by invitation
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06438445 on ClinicalTrials.gov ↗ ← All trials in Brazil