Ivonescimab (SMT112 is named as a drug or biological intervention in 2 clinical trials in our China trial register, none of which are currently recruiting. The lead sponsor is Akeso. Registered phases: Phase 1 and Phase 3. Conditions studied include Pancreas Cancer; Pancreas Cancer, Duct Cell Adenocarcinoma; Non-Squamous Non-small Cell Lung Cancer.
| NCT ID | Study | Phase | Status |
|---|---|---|---|
| NCT06913218 | A Study of mRNA Vaccines AK154 Monotherapy or in Combination With AK104/AK112,and Sequential mFOLFIRINOX in Surgically Resected PDAC (ClinicalTrials.gov ↗) Pancreas Cancer, Pancreas Cancer, Duct Cell Adenocarcinoma |
Phase 1 | Not yet open |
| NCT05184712 | Phase 3 Clinical Study of AK112 for NSCLC Patients (ClinicalTrials.gov ↗) Non-Squamous Non-small Cell Lung Cancer |
Phase 3 | Active, closed |
Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.
| Condition (as registered) | Trials |
|---|---|
| Pancreas Cancer | 1 |
| Pancreas Cancer, Duct Cell Adenocarcinoma | 1 |
| Non-Squamous Non-small Cell Lung Cancer | 1 |
| Lead sponsor | Trials |
|---|---|
| Akeso | 2 |
| Register | Ivonescimab (SMT112 trials |
|---|---|
| Clinical trials in China | 2 |
A trial with sites in more than one country appears in each of those registers.
Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Ivonescimab (SMT112 works or whether it is effective. Each trial links to its own record so you can check it yourself.
This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Ivonescimab (SMT112 (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 24 Sep 2026.