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Priya Life Science Compound trial record
Compound · clinical trials

Cadonilimab lenvatinib clinical trials

Also listed in trial records as AK104
Source: ClinicalTrials.gov, U.S. National Library of Medicine — the 51 trials in our China register that name Cadonilimab lenvatinib as an intervention. Synced 14 Oct 2026
51Current trials
31Recruiting now
28Lead sponsors
1Country register
At a glance

Cadonilimab lenvatinib is named as an intervention in 51 current clinical trials in our China register. 31 are recruiting patients now. The most common phase is Phase 2. The sponsor with the most trials is Akeso (17). The most-studied condition is Cervical Cancer.

Patient leaflets for Cadonilimab lenvatinib

The package leaflet is the official guide for patients that comes with every medicine. These links go to the regulators that publish it.

  • UK
    United Kingdom: Search MHRA Products
    Patient information leaflets and SmPCs for UK-licensed products.
  • US
    United States: Search DailyMed
    FDA-approved labels, including patient and medication guides.

Leaflets differ between brands and countries; always read the one that comes with your own medicine. This is regulatory information, not medical advice.

Trials by status

  • Recruiting3161%
  • Not yet open612%
  • Active, closed1325%
  • By invitation12%

Trials by phase

  • Phase 22855%
  • Phase 31122%
  • Phase 1/2714%
  • Phase 136%
  • Phase 2/324%
01

Clinical trials of Cadonilimab lenvatinib

51 trials
StudyPhaseStatusLead sponsorRegisters
A Phase III Study of AK104 as Adjuvant Therapy in HCC With High Risk of Recurrence After Curative Resection
NCT05489289 · ClinicalTrials.gov ↗ · Hepatocellular Carcinoma
Phase 3 Recruiting Akeso China
IC Plus Low-dose Radiation Plus Cadonilimab in LANPC
NCT05941741 · ClinicalTrials.gov ↗ · Nasopharyngeal Carcinoma, Immune Checkpoint Inhibitor, Radiotherapy
Phase 3 Recruiting Sun Yat-sen University China
A Study of AK104/Placebo Plus AK109/Placebo And Paclitaxel in Gastric or Gastroesophageal Junction Adenocarcinoma
NCT06341335 · ClinicalTrials.gov ↗ · Gastric and Gastroesophageal Junction Adenocarcinoma
Phase 3 Recruiting Akeso China
A Study of AK104+Lenvatinib in Combination With Transarterial Chemoembolization (TACE) Versus TACE in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma
NCT06371157 · ClinicalTrials.gov ↗ · Hepatocellular Carcinoma
Phase 3 Recruiting Akeso China
Cadonilimab (AK104) Combined With Chemotherapy and Bevacizumab as First-line Treatment for RAS Mutated or Right Sided-metastatic MSS Colorectal Cancer
NCT06566755 · ClinicalTrials.gov ↗ · Colorectal Cancer
Phase 3 Recruiting Caigang Liu China
A Study of AK104 in Subjects With Unresectable Locally Advanced NSCLC
NCT06617416 · ClinicalTrials.gov ↗ · NSCLC (Non-small Cell Lung Cancer)
Phase 3 Recruiting Akeso China
Neoadjuvant/Adjuvant AK104 in Microsatellite Instability-high or Mismatch Repair-deficient, Resectable Colon Cancer
NCT07412613 · ClinicalTrials.gov ↗ · Resectable Colon Cancer, MSI-H/dMMR Colorectal Cancer
Phase 3 Recruiting Akeso China
FAPI-Guided Radiotherapy With Cadonilimab and Standard Chemotherapy for Colorectal Peritoneal Metastasis: A Phase III Randomized Controlled Trial (TORHC-PM02)
NCT07815834 · ClinicalTrials.gov ↗ · Colon Rectal Cancer Adenocarcinoma, Peritoneal (Metastatic) Cancer, Second-line Treatment
Phase 3 Recruiting Fudan University China
DV Combined With Cadonilimab in Subjects With HER2-expressing Gastric Cancer and Gastroesophageal Junction Adenocarcinoma After Progression on First-line Therapy
NCT06221748 · ClinicalTrials.gov ↗ · Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
Phase 2/3 Recruiting RemeGen Co., Ltd China
A Multi-center, Randomized, Double-blind, Phase II/III Clinical Trial of AK104 or Placebo in Combination With Chemotherapy as Second-line or More Lines for Recurrent or Metastatic Nasopharyngeal Carcinoma (NPC)
NCT06241599 · ClinicalTrials.gov ↗ · Recurrent or Metastatic Nasopharyngeal Carcinoma
Phase 2/3 Recruiting Sun Yat-sen University China
AK104 With Chemotherapy as Neoadjuvant and Adjuvant Therapy for Resectable Non-small Cell Lung Cancer
NCT05377658 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
Phase 2 Recruiting Henan Cancer Hospital China
Neoadjuvant Treatment With mFOLFOXIRI Plus Cadonilimab (AK104) Versus mFOLFOX6 in Locally Advanced Colorectal Cancer
NCT05571644 · ClinicalTrials.gov ↗ · Colorectal Cancer
Phase 2 Recruiting Sun Yat-sen University China
Cadonilimab Plus Anlotinib for R/M/P Cervical Cancer
NCT05817214 · ClinicalTrials.gov ↗ · Cervical Cancer
Phase 2 Recruiting Zhongnan Hospital China
A Study of AK104 With Chemotherapy as First-line Treatment in Patients With Advanced Pancreatic Cancer
NCT05859750 · ClinicalTrials.gov ↗ · Pancreatic Cancer
Phase 2 Recruiting Akeso China
Cadonilimab (AK104) Plus Chemotherapy as First-line Treatment in Non-squamous Non-Small Cell Lung Cancer (NSCLC) Patients With Programmed Cell Death Ligand 1 (PD-L1) Negative
NCT06001151 · ClinicalTrials.gov ↗ · Carcinoma, Non-Small-Cell Lung
Phase 2 Recruiting Qian Chu China
AK104 in Combination With AK112 Plus Chemotherapy(SOX/XELOX) as First-line Treatment for Advanced G/GEJ Cancer
NCT06196697 · ClinicalTrials.gov ↗ · Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
Phase 2 Recruiting Harbin Medical University China
Phase II Study on Neoadjuvant Therapy of AK104 Combined With Nab-paclitaxel/Carboplatin in Fertility Preserving Surgery
NCT06209294 · ClinicalTrials.gov ↗ · Neoadjuvant Immunotherapy, Cervical Cancer, Fertility-sparing Surgery
Phase 2 Recruiting Xiaohua Wu China
Cadonilimab and Lenvatinib for Conversion Therapy in Unresectable Hepatocellular Carcinoma
NCT06215651 · ClinicalTrials.gov ↗ · Cadonilimab and Lenvatinib
Phase 2 Recruiting Peking Union Medical College Hospital China
Neoadjuvant Chemoimmunotherapy and Extrafascial Hysterectomy for IB2 Cervical Cancer
NCT06289751 · ClinicalTrials.gov ↗ · Cervical Cancer, Neoadjuvant Chemoimmunotherapy, Radical Hysterectomy
Phase 2 Recruiting Tongji Hospital China
A Trial of Cadonilimab With Adriamycin in Patients With Advanced Soft Tissue Sarcoma
NCT06367075 · ClinicalTrials.gov ↗ · Advanced Soft-tissue Sarcoma
Phase 2 Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology China
SBRT, Chemotherapy, and AK104 Neoadjuvant Therapy for Triple-negative Breast Cancer (TNBC)
NCT06401005 · ClinicalTrials.gov ↗ · Breast Cancer
Phase 2 Recruiting Hubei Cancer Hospital China
Cadonilimab in Combination With Lenvatinib and Hepatic Arterial Infusion Chemotherapy (HAIC) for the Treatment of Unresectable Hepatocellular Carcinoma
NCT06406634 · ClinicalTrials.gov ↗ · Hepatocellular Carcinoma
Phase 2 Recruiting Hunan Cancer Hospital China
A Prospective, Open-label, Single-center, Single-arm Phase II Clinical Study of Cadonilimab (AK104) Combined With Monotherapy Chemotherapy in Patients With Advanced Non-small Cell Lung Cancer With Negative Driver Genes and Failed Immunotherapy
NCT06467500 · ClinicalTrials.gov ↗ · Non-small Cell Lung Cancer
Phase 2 Recruiting Xin-Hua Xu China
Cadonilimab With Chemoradiation for Recurrent and Oligometastatic Endometrial Carcinoma
NCT06532539 · ClinicalTrials.gov ↗ · Endometrial Neoplasms, Neoplasm Recurrence, Local, Neoplasm Metastasis
Phase 2 Recruiting Shandong Cancer Hospital and Institute China
An Exploratory, Multi-cohort Phase II Study of Combination Therapy With AK104 and AK112 for Recurrent Ovarian Cancer
NCT06560112 · ClinicalTrials.gov ↗ · Recurrent Ovarian Cancer
Phase 2 Recruiting Akeso China
IN10018 With Nab-Paclitaxel and Cadonilimab for Metastatic or Recurrent Gastric-Type Cervical Adenocarcinoma: Phase 2 Trial
NCT06654011 · ClinicalTrials.gov ↗ · Cervical Adenocarcinoma, Gastric-type Endocervical Adenocarcinoma
Phase 2 Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology China
A Phase II Clinical Study of AK104/AK112 in Combination With TT-00420 Tablet for Advanced HCC.
NCT07052253 · ClinicalTrials.gov ↗ · Hepatocellular Carcinoma (HCC)
Phase 2 Recruiting Akeso China
Perioperative Cadonilimab Combined With Neoadjuvant Chemotherapy in Resectable Esophageal Squamous Cell Carcinoma (ESCC)
NCT07263919 · ClinicalTrials.gov ↗ · Resectable Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma
Phase 2 Recruiting Akeso China
A Study of AK109 and AK104 in Advanced Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma
NCT04982276 · ClinicalTrials.gov ↗ · Gastric Adenocarcinoma and Gastroesophageal Junction Adenocarcinoma
Phase 1/2 Recruiting Akeso China
A Study of AK109 Combined With AK104 in Patients With Advanced Solid Tumors
NCT05142423 · ClinicalTrials.gov ↗ · Advanced Solid Tumor
Phase 1/2 Recruiting Akeso China
Cadonilimab Combination Regimen as First-line Treatment for HER2-expressing GC/GEJ Patients
NCT06650332 · ClinicalTrials.gov ↗ · Metastatic HER2 Positive Gastroesophageal Junction Cancer
Phase 1/2 Recruiting Zhejiang Cancer Hospital China
A Study of AK104/Tislelizumab With Chemotherapy as First-line Treatment in PD-L1 TPS < 1% Non-small Cell Lung Cancer
NCT05990127 · ClinicalTrials.gov ↗ · Locally Advanced or Metastatic NSCLC
Phase 3 Not yet open Akeso China
A Study of Cadonilimab Combined With AK112 as Second-line Therapy in Patients With Advanced Hepatocellular Carcinoma
NCT06196775 · ClinicalTrials.gov ↗ · Hepatocellular Carcinoma
Phase 2 Not yet open Harbin Medical University China
Study of Cadonilimab (AK104) Plus Eribulin vs. Eribulin Monotherapy for Recurrent or Metastatic Triple-negative Breast Cancer
NCT06202313 · ClinicalTrials.gov ↗ · Triple Negative Breast Cancer
Phase 2 Not yet open Shengjing Hospital China
Neoadjuvant Cadonilimab Plus Chemotherapy for Locally Advanced Esophagogastric Junction and Gastric Cancer Trial
NCT06310473 · ClinicalTrials.gov ↗ · Gastric Cancer, Esophagogastric Junction Cancer
Phase 2 Not yet open Nanfang Hospital, Southern Medical University China
RC48 Plus AK104 as First-line Treatment for HER2-overexpressing Advanced Gastric Cancer
NCT06492317 · ClinicalTrials.gov ↗ · HER2-positive Gastric Cancer
Phase 2 Not yet open The First Affiliated Hospital of Zhengzhou University China
A Study to Evaluate the PK Similarity of AK104 in Healthy Chinese Male Participations
NCT07619001 · ClinicalTrials.gov ↗ · Healthy Male Adults Participants
Phase 1 Not yet open Akeso China
A Trial of AK104 or AK112 in Combination With Axitinib in Patients With Metastatic Mucosal Melanoma
NCT06424626 · ClinicalTrials.gov ↗ · Melanoma, Mucosal Melanoma, Metastatic Melanoma
Phase 1 By invitation Peking University Cancer Hospital & Institute China
A Study of AK104 Plus Platinum-containing Chemotherapy±Bevacizumab as First-line Treatment for Persistent, Recurrent, or Metastatic Cervical Cancer
NCT04982237 · ClinicalTrials.gov ↗ · Cervical Cancer
Phase 3 Active, closed Akeso China
A Study of AK104/Placebo Combined With Chemoradiotherapy For The Treatment of Locally Advanced Cervical Cancer
NCT05235516 · ClinicalTrials.gov ↗ · Locally Advanced Cervical Carcinoma
Phase 3 Active, closed Akeso China
AK104 in Locally Advanced MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer
NCT04556253 · ClinicalTrials.gov ↗ · MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer
Phase 2 Active, closed Peking University China
A Phase II Study of AK104 Plus Lenvatinib and TACE in HCC
NCT05319431 · ClinicalTrials.gov ↗ · Unresectable, Non-metastatic Hepatocellular Carcinoma
Phase 2 Active, closed Akeso China
Study of Cadonilimab (AK104) Plus Lenvatinib in Patients With Advanced Endometrial Cancer
NCT05824481 · ClinicalTrials.gov ↗ · Endometrial Cancer, Endometrial Adenocarcinoma
Phase 2 Active, closed Sun Yat-sen University China
Combination of Cadonilimab and Chemoradiotherapy in Esophageal Cancer (EC-CRT-006)
NCT06143748 · ClinicalTrials.gov ↗ · Esophagus Cancer
Phase 2 Active, closed Sun Yat-sen University China
Cadonilimab(AK104) Plus Concurrent Chemoradiotherapy in Patients With Locally Advanced, Unresectable, Stage III NSCLC
NCT06448910 · ClinicalTrials.gov ↗ · NSCLC, Locally Advanced Lung Carcinoma
Phase 2 Active, closed Fudan University China
AK117 (Anti-CD47 mAb) Plus Cetuximab or AK104 (Anti-PD-1/CTLA-4 bsAb) as Second-Line Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
NCT06508606 · ClinicalTrials.gov ↗ · Head and Neck Squamous Cell Carcinoma
Phase 2 Active, closed West China Hospital China
A Study of AK104 Plus Axitinib in Advanced/Metastatic Special Pathological Subtypes of Renal Cell Carcinoma
NCT05808608 · ClinicalTrials.gov ↗ · Renal Cell Carcinoma, First-line Treatment, Non Clear Cell Renal Cell Carcinoma
Phase 1/2 Active, closed Hao Zeng China
AK112 and AK104 With or Without Chemotherapy in Advanced Non-small Cell Lung Cancer
NCT05904379 · ClinicalTrials.gov ↗ · Advanced Non-small-cell Lung Cancer
Phase 1/2 Active, closed Akeso China
Phase 1b/2 Study of LDRT in Combination With AK104 Plus Chemotherapy as First-line Treatment for ES-SCLC
NCT06477523 · ClinicalTrials.gov ↗ · SCLC, Extensive Stage
Phase 1/2 Active, closed Sichuan University China
Intrathecal Combination of Programmed Death-1 (PD-1)/Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Bispecific Antibody and Pemetrexed for Leptomeningeal Metastasis
NCT06762080 · ClinicalTrials.gov ↗ · Leptomeningeal Metastasis
Phase 1/2 Active, closed Guangzhou Medical University China
A Study Evaluating Cadonilimab Injection in Combination With Regorafenib for the Advanced Hepatocellular Carcinoma
NCT05644379 · ClinicalTrials.gov ↗ · Advanced Hepatocellular Carcinoma That Has Failed at Least One Prior Systemic Therapy
Phase 1 Active, closed Tianjin Medical University Cancer Institute and Hospital China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Trial titles and statuses are copied from the registry as published.

02

Conditions studied with Cadonilimab lenvatinib

66 conditions
Cervical Cancer4Hepatocellular Carcinoma4Gastroesophageal Junction Adenocarcinoma2Non-small Cell Lung Cancer2Gastric Cancer2Colorectal Cancer2Recurrent or Metastatic Nasopharyngeal Carcinoma1Locally Advanced Cervical Carcinoma1Cadonilimab and Lenvatinib1Advanced Soft-tissue Sarcoma1Pancreatic Cancer1Head and Neck Squamous Cell Carcinoma1
All 66 conditions
Condition (as registered)Trials
Cervical Cancer4
Hepatocellular Carcinoma4
Gastroesophageal Junction Adenocarcinoma2
Non-small Cell Lung Cancer2
Gastric Cancer2
Colorectal Cancer2
Recurrent or Metastatic Nasopharyngeal Carcinoma1
Locally Advanced Cervical Carcinoma1
Cadonilimab and Lenvatinib1
Advanced Soft-tissue Sarcoma1
Pancreatic Cancer1
Head and Neck Squamous Cell Carcinoma1
Gastric Adenocarcinoma1
Unresectable, Non-metastatic Hepatocellular Carcinoma1
NSCLC1
Locally Advanced Lung Carcinoma1
Advanced Non-small-cell Lung Cancer1
Breast Cancer1
Resectable Colon Cancer1
MSI-H/dMMR Colorectal Cancer1
Melanoma1
Mucosal Melanoma1
Metastatic Melanoma1
Nasopharyngeal Carcinoma1
Immune Checkpoint Inhibitor1
Radiotherapy1
Chemotherapy1
Locally Advanced or Metastatic NSCLC1
HER2-positive Gastric Cancer1
Advanced Hepatocellular Carcinoma That Has Failed at Least One Prior Systemic Therapy1
Triple Negative Breast Cancer1
Esophagus Cancer1
MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer1
Gastric Adenocarcinoma and Gastroesophageal Junction Adenocarcinoma1
Esophagogastric Junction Cancer1
Carcinoma, Non-Small-Cell Lung1
Endometrial Cancer1
Endometrial Adenocarcinoma1
Healthy Male Adults Participants1
Renal Cell Carcinoma1
First-line Treatment1
Non Clear Cell Renal Cell Carcinoma1
Sarcomatoid Renal Cell Carcinoma1
SCLC, Extensive Stage1
Gastric and Gastroesophageal Junction Adenocarcinoma1
Advanced Solid Tumor1
Resectable Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma1
Colon Rectal Cancer Adenocarcinoma1
Peritoneal (Metastatic) Cancer1
Second-line Treatment1
Radiation Therapy1
Metastatic HER2 Positive Gastroesophageal Junction Cancer1
NSCLC (Non-small Cell Lung Cancer)1
Leptomeningeal Metastasis1
Endometrial Neoplasms1
Neoplasm Recurrence, Local1
Neoplasm Metastasis1
Neoadjuvant Chemoimmunotherapy1
Radical Hysterectomy1
Extrafascial Hysterectomy1
Hepatocellular Carcinoma (HCC)1
Cervical Adenocarcinoma1
Gastric-type Endocervical Adenocarcinoma1
Recurrent Ovarian Cancer1
Neoadjuvant Immunotherapy1
Fertility-sparing Surgery1
05

Related compounds

06

Questions about Cadonilimab lenvatinib trials

How many clinical trials are testing Cadonilimab lenvatinib?

51 current trials in our China register name Cadonilimab lenvatinib (also registered as AK104) as a drug or biological intervention, as of the registry sync on 14 October 2026. Completed and withdrawn studies are not counted.

Are Cadonilimab lenvatinib trials recruiting patients?

Yes. 31 of the 51 trials are recruiting: 31 with sites in China. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Who sponsors Cadonilimab lenvatinib clinical trials?

Akeso (17), Sun Yat-sen University (5), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (2) and Harbin Medical University (2), among 28 lead sponsors in total. The number in brackets is how many trials each organisation leads.

Where does this information come from?

Every trial, status, phase and sponsor on this page is copied from public ClinicalTrials.gov records by a daily sync. Nothing here describes how Cadonilimab lenvatinib works or whether it is effective, and it is not medical advice.

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How this page is built

Everything on this page is copied from public ClinicalTrials.gov registry records — it is not written from memory, and nothing here describes how Cadonilimab lenvatinib works or whether it is effective. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our country trial registers, collects every trial that lists Cadonilimab lenvatinib (or a registered synonym) as a drug or biological intervention, and tabulates the registry fields directly. Placebos and generic comparators are excluded. There is no AI drafting and no per-compound editorial pass, and the page has not been clinically reviewed. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The ClinicalTrials.gov data on this page was last retrieved on 14 Oct 2026. How every register is built: methodology · fixes we have made: corrections log.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.