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Lantus vs Humalog

Insulin Glargine  ·  Insulin Lispro

Both are insulins. Here is how Lantus and Humalog compare on class, mechanism, dosing, approval and supply.

At a glance

LantusInsulin Glargine
HumalogInsulin Lispro
Brand names
Lantus / Basaglar
Humalog
Drug class
Long-acting insulin
Rapid-acting insulin
Route
Subcutaneous
Intravenous, Subcutaneous
Marketed by
Sanofi
Eli Lilly
First FDA approval
20 Apr 2000
14 Jun 1996
US shortage
Not in shortage
Not in shortage

Key differences

What each one treats

LantusInsulin Glargine

LANTUS is indicated to improve glycemic control in adult and pediatric patients with diabetes mellitus. LANTUS is a long-acting human insulin analog indicated to improve glycemic control in adult and pediatric patients with diabetes mellitus. ( 1 ) Limitations of Use Not recommended for the treatment of diabetic ketoacidosis. ( 1 ) Limitations of Use LANTUS is not recommended for the treatment of diabetic ketoacidosis.

HumalogInsulin Lispro

HUMALOG is indicated to improve glycemic control in adult and pediatric patients with diabetes mellitus. HUMALOG is a rapid acting human insulin analog indicated to improve glycemic control in adult and pediatric patients with diabetes mellitus. ( 1 )

How each one works

LantusLong-acting insulin

12.1 Mechanism of Action The primary activity of insulin, including insulin glargine, is regulation of glucose metabolism. Insulin and its analogs lower blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis, and enhances protein synthesis.

HumalogRapid-acting insulin

12.1 Mechanism of Action Regulation of glucose metabolism is the primary activity of insulins and insulin analogs, including insulin lispro. Insulins lower blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulins inhibit lipolysis and proteolysis, and enhance protein synthesis.

Related comparisons

Lantus VS Tresiba Lantus VS NovoRapid Tresiba VS Humalog NovoRapid VS Humalog

Read more

Lantus profile Humalog profile Insulins All comparisons
This is not medical advice, and not a recommendation of one drug over the other.

Which medicine is right for a given person depends on their diagnosis, other conditions, other medicines, kidney and liver function, pregnancy, and cost or reimbursement — none of which this page knows. Two drugs in the same class are not automatically interchangeable. Never start, stop or switch a prescription medicine on the basis of a web page; that decision belongs to you and your clinician or pharmacist.

Class and summary text is written by the Priya Life Science editorial team. Label, mechanism, route, manufacturer and approval data come from the U.S. FDA via the openFDA API; shortage status from the FDA Drug Shortage Database. Approvals, indications and brand names differ between the US, EU/Ireland (EMA/HPRA) and other regions — a drug approved in one may not be approved, or may carry a different name, in another.