Examining Olive Oil Extract on Knee Comfort and Function

NCT07514013 · tracked via the Priya Life Science USA tracker

Sponsor

Applied Food Sciences Inc

Phase

Not applicable

Started

2026-04

Last updated

2026-04-15

Condition(s) studied

Healthy Adult MaleHealthy Adult FemalesJoint Discomfort

Investigational drug(s) / intervention(s)

Olive Oil ExtractPlacebo

Olive Oil Extract: The investigational product is an olive oil extract dietary supplement formulated for oral consumption. The product is provided in capsule form and is intended for general wellness use, including support of joint comfort and function. Each capsule delivers a standardized amount of olive-derived bioactive compounds, including oleocanthal and oleacein.

Placebo: The comparator product is a matched placebo formulated from refined olive oil extract and is similar in appearance, taste, and packaging to the investigational product. The placebo is intended to serve as a control for study comparisons and does not contain the standardized olive-derived bioactive compounds present in the investigational product.

Study summary

The goal of this study is to learn if an olive oil extract works to improve knee pain and discomfort in adults. The main questions it aims to answer are: 1) Does the olive oil extract improve the perceptions of knee pain and discomfort, and 2) Does the olive oil extract improve knee function in adults?

The main procedures in the study include:

* Screening and informed consent
* Take one assigned study capsule (supplement or placebo) daily with food for 6 weeks
* Complete digital questionnaires about your knee pain, stiffness, and function at scheduled times
* Complete a Day 1 acute assessment and two simple functional movement tests at home as described below
* If possible, connect a compatible wearable device to allow collection of sleep and physical activity data as detailed below.
* Collect saliva samples at home using a provided kit at designated timepoints
* Record any pain medications taken during the study or any side effects

Eligibility

Sex

ALL

Min age

40 Years

Max age

75 Years

Healthy volunteers

Accepted

Inclusion Criteria: Participants must meet all of the following criteria to be eligible for participation: * Adults aged 40 to 75 years * Self-reported knee discomfort for at least 3 months * Willing and able to take one study capsule daily for the duration of the study * Willing and able to complete digital questionnaires, functional movement tasks, and other study activities using the Alethios platform * Willing and able to wear a compatible activity-tracking device throughout the study * Willing and able to collect saliva samples at home using a provided kit, if applicable * Able to read and understand English * Willing to provide informed consent electronically Exclusion Criteria: Participants will be excluded if any of the following apply: * Diagnosis of inflammatory joint disease (e.g., rheumatoid arthritis) or other systemic inflammatory conditions affecting the knee * Any current or prior diagnosis from a licensed medical provider of knee disease * Knee surgery or significant knee injury within the past 6 months * Planned knee surgery during the study period * Known allergy or sensitivity to olive-derived products or any component of the study product * Current use of investigational drugs or participation in another research study during the study period * Any medical condition or circumstance that, in the opinion of the investigator, would make participation unsafe or interfere with study participation or data quality

Primary outcome measure(s)

Change in Knee pain (KOOS Pain subscale) — After 0, 1, 2, 3, 4, 5, and 6 weeks of supplementation.
Change in knee pain from baseline to Week 6. Measured by KOOS (0-100 where 0=Worst knee problems, 100=No knee problems).

Trial sites (1)

Facility	City	Region	Status
Alethios, Inc.	San Francisco	California	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07514013 on ClinicalTrials.gov ↗ ← All trials in the USA