Ireland
--:--IST
Latest
Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide
Clinical Trials in the USA / NCT07473544
Active, not recruiting Not applicable

Essential Oil Inhalation and Acute Stress Response in Healthy Adults

NCT07473544 · tracked via the Priya Life Science USA tracker
Sponsor
dōTERRA International
Phase
Not applicable
Started
2026-03-10
Last updated
2026-05-12

Condition(s) studied

Psychological Stress

Investigational drug(s) / intervention(s)

Essential Oil InhalationPlacebo Aroma Stick

Essential Oil Inhalation: Participants inhale an essential oil or essential oil blend administered via an individual aroma stick. At prespecified time points during baseline, stress induction (Trier Social Stress Test - Group version), and recovery or guided meditation procedures, participants are instructed to take five normal breaths from the aroma stick. The intervention is delivered in a randomized, double-blind manner and is standardized across participants within each study phase.

Placebo Aroma Stick: Participants inhale a placebo comparator administered via an aroma stick identical in appearance and delivery method to the experimental intervention but without active essential oil components. The inhalation schedule and procedures are identical to those used in the experimental arm to maintain blinding.

Study summary

This randomized, double-blind, placebo-controlled study evaluates the acute physiological and subjective responses to essential oil inhalation in healthy adults. Participants are assigned to inhale either an essential oil or a placebo via an aroma stick during standardized laboratory procedures designed to induce temporary psychosocial stress (Trier Social Stress Test - Group version) and during a guided relaxation session.

Physiological responses, including heart rate, heart rate variability, and electrodermal activity, are measured using a wearable sensor. Subjective stress and affect are assessed using validated questionnaires and visual analog scales. The purpose of this study is to characterize short-term autonomic and self-reported responses associated with essential oil inhalation under controlled experimental conditions. This study is exploratory and is not intended to diagnose, treat, or prevent any medical condition.

Eligibility

Sex
ALL
Min age
18 Years
Max age
45 Years
Healthy volunteers
Accepted
Inclusion Criteria: Age 18-45 years, inclusive Able to read, write, and understand English Willing and able to provide informed consent Willing to attend two in-person study visits Generally healthy, as determined by medical history and screening review Exclusion Criteria: Known asthma, chronic obstructive pulmonary disease (COPD), significant lung disease, heart disease, or other medical condition that may compromise safety or data integrity Pregnancy or pregnancy within the past 90 days Known allergy or sensitivity to essential oils or study placebo materials Current smoking, vaping, chewing tobacco, or use of recreational drugs Regular use of essential oils applicable to the study phase (\>3 times per week for ≥2 weeks within the past month) without a minimum 1-month washout Unwillingness to abstain from alcohol for at least 72 hours prior to each study visit Failure to meet inclusion criteria

Primary outcome measure(s)

  • Change in Visual Analog Scale (VAS) Stress Area Under the Curve (AUC) — Baseline through 30 minutes post-stressor recovery (Study Visit 1)
    Area under the curve (AUC) for self-reported stress measured using a Visual Analog Scale (VAS) across baseline, stress induction (Trier Social Stress Test - Group version), and post-stressor recovery periods. The VAS-stress scale ranges from low stress to high stress, with higher scores indicating greater perceived stress.

Trial sites (1)

FacilityCityRegionStatus
dōTERRA International Pleasant Grove Utah

More dōTERRA International trials in the USA

Essential Oil-Based Product System for Digestive Support Starting soon

Other trials for the same condition

NeuroFinance Human Stress Trial During Financial and Informational Volatility Enrolling by invitation
Sleep More, Stress Less: 90-Day Trial of Neuralli Mood Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07473544 on ClinicalTrials.gov ↗ ← All trials in the USA