Molecular Indicators of Systematic Fitness

Condition(s) studied

Investigational drug(s) / intervention(s)

There is no intervention.: The investigators are not administering an intervention for this study. To opportunistically capture prospective data, the investigators give participants the option for re-testing after a period of time where participants are undergoing a self-directed intervention (i.e., no influence of the research staff), such as training for a marathon or other fitness event.

Study summary

The goal of this study is to characterize associations between cardiorespiratory fitness, as measured by VO₂max/VO₂peak, and blood-based molecular measurements in adults. This is an observational study where research staff measures VO₂max/VO₂peak and collects fasted, resting blood samples on the same day. The main questions it aims to answer are:

1. Can a multi-analyte blood panel accurately predict directly measured VO₂max/VO₂peak?
2. How do these blood-based features vary across age, sex, and self-reported or documented physical activity profiles?
3. Are the predictor analytes able to capture changes in VO₂max/VO₂peak caused by a self-directed intervention (e.g., training for a marathon)?
4. What is the analytic reliability of the predictor biomarkers?

Eligibility

Primary outcome measure(s)

• A multi-analyte biomarker panel to predict maximal aerobic capacity — Day 1
  The primary outcome is developing a multi-protein biomarker panel that can accurately estimate cardiorespiratory fitness from the blood.
• The change in VO2max/VO2peak and a multi-analyte biomarker panel after a self-directed training program. — From day 1 through study completion, average of 3 months
  In a subset of individuals who opt-in for a second study visit, the investigators will analyze the change in VO2max and the multi-analyte biomarker from pre- to post-testing.

Trial sites (1)

Other trials for the same condition