A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in the United States
Condition(s) studied
Investigational drug(s) / intervention(s)
NT 201: Clostridium Botulinum neurotoxin A (150 kiloDalton \[kD\], free of complexing proteins), powder for solution for injection.
NT 201 Placebo: NT 201 matching-placebo
Study summary
The purpose of this study is to assess the safety and efficacy of NT 201 compared with placebo in participants with moderate to severe platysma prominence. The study will be conducted in two periods: Main Period (MP) and Open label Extension Period (OLEX).
Eligibility
Primary outcome measure(s)
- Composite Achievement of Grade 1 or Grade 2 And at Least a 2-Grade Improvement From Baseline Based on Both the Investigator's Assessment and Participant's Self-Assessment Using the Merz Aesthetics Platysma Scale - Dynamic (MAPS-D) At Week 2 of MP — At Week 2 of MP
MAPS-D is a validated five-point scale that will be used to grade the platysma prominence. Scores range from Grade 1 (none to minimal) to Grade 5 (very severe). A lower score indicates improvement.
Trial sites (28)
| Facility | City | Region | Status |
|---|---|---|---|
| Merz Investigative Site | Scottsdale | Arizona | |
| Merz Investigative Site | Encino | California | |
| Merz Investigative Site | Los Angeles | California | |
| Merz Investigative Site | Redondo Beach | California | |
| Merz Investigative Site | Santa Monica | California | |
| Merz Investigative Site | Vista | California | |
| Merz Investigative Site | Greenwood Village | Colorado | |
| Merz Investigative Site | Westport | Connecticut | |
| Merz Investigative Site | Washington D.C. | District of Columbia | |
| Merz Investigative Site | Aventura | Florida | |
| Merz Investigative Site | Boca Raton | Florida | |
| Merz Investigative Site | Bradenton | Florida | |
| Merz Investigative Site | Coral Gables | Florida | |
| Merz Investigative Site | Coral Gables | Florida | |
| Merz Investigative Site | West Palm Beach | Florida | |
| Merz Investigative Site | Alpharetta | Georgia | |
| Merz Investigative Site | Naperville | Illinois | |
| Merz Investigative Site | Hunt Valley | Maryland | |
| Merz Investigative Site | Mount Kisco | New York | |
| Merz Investigative Site | New York | New York | |
| Merz Investigative Site | New York | New York | |
| Merz Investigative Site | Chapel Hill | North Carolina | |
| Merz Investigative Site | Wilmington | North Carolina | |
| Merz Investigative Site | Ardmore | Pennsylvania | |
| Merz Investigative Site | Nashville | Tennessee | |
| Merz Investigative Site | Dallas | Texas | |
| Merz Investigative Site | Arlington | Virginia | |
| Merz Investigative Site | San Juan | Puerto Rico |
More Merz North America, Inc. trials in the USA
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07122193 on ClinicalTrials.gov ↗ ← All trials in the USA