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Clinical Trials in the USA / NCT07090161
Recruiting Phase 2

Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension

NCT07090161 · tracked via the Priya Life Science USA tracker
Sponsor
Vanda Pharmaceuticals
Phase
Phase 2
Started
2025-09-15
Last updated
2026-02-27

Condition(s) studied

HypertensionUncontrolled Hypertension

Investigational drug(s) / intervention(s)

iloperidone →Placebo

iloperidone: iloperidone

Placebo: placebo comparator

Study summary

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Iloperidone for the Treatment of Participants with Uncontrolled Hypertension

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria: * SiSBP \>/= 130 mmHg despite \>8 weeks treatment w/ 1 or more antihypertensive therapies Exclusion Criteria: * Confirmed Grade 3/severe hypertension (SiSBP \>/= 180 mmHg, SiDBP \>/= 120 mmHg), unstable cardiac disease, renal insufficiency

Primary outcome measure(s)

  • Change from baseline to treatment week 4 in SiSBP — screening to treatment week 4

Trial sites (28)

FacilityCityRegionStatus
Vanda Investigative Site Phoenix Arizona Not Yet Recruiting
Vanda Investigative Site Tempe Arizona Recruiting
Vanda Investigative Site Tucson Arizona Not Yet Recruiting
Vanda Investigative Site Chula Vista California Recruiting
Vanda Investigative Site Dublin California Recruiting
Vanda Investigative Site Valencia California Not Yet Recruiting
Vanda Investigative Site Walnut Creek California Recruiting
Vanda Investigative Site Doral Florida Not Yet Recruiting
Vanda Investigative Site Fort Myers Florida Recruiting
Vanda Investigative Site Columbus Georgia Recruiting
Vanda Investigative Site Oak Brook Illinois Recruiting
Vanda Investigative Site Tinley Park Illinois Recruiting
Vanda Investigative Site El Dorado Kansas Recruiting
Vanda Investigative Site Wichita Kansas Recruiting
Vanda Investigative Site Lexington Kentucky Recruiting
Vanda Investigative Site Hazelwood Missouri Recruiting
Vanda Investigative Site Las Vegas Nevada Not Yet Recruiting
Vanda Investigative Site Mount Kisco New York Not Yet Recruiting
Vanda Investigative Site Rochester New York Not Yet Recruiting
Vanda Investigative Site Kinston North Carolina Recruiting
Vanda Investigative Site Cincinnati Ohio Recruiting
Vanda Investigative Site Norman Oklahoma Recruiting
Vanda Investigative Site Oklahoma City Oklahoma Not Yet Recruiting
Vanda Investigative Site Charleston South Carolina Recruiting
Vanda Investigative Site Carrollton Texas Not Yet Recruiting
Vanda Investigative Site Salt Lake City Utah Not Yet Recruiting
Vanda Investigative Site Burke Virginia Recruiting
Vanda Investigative Site Norfolk Virginia Recruiting

More Vanda Pharmaceuticals trials in the USA

Study to Evaluate the Efficacy and Safety of Ponesimod (VSP-128) in Patients With Moderately to Severely Active Ulcerative Colitis Recruiting
Patient Registry of Blind Subjects With Sleep-related Problems Recruiting
ODYSSEY: A Study to Investigate the Efficacy of Tradipitant in Treating Severe or Critical COVID-19 Infection Enrolling by invitation
Motion Delos: An Open Label Safety and Efficacy of Tradipitant in Participants Affected by Motion Sickness Active, not recruiting
Randomized Withdrawal Study in Patients With Schizophrenia Recruiting

Other trials for the same condition

RADIANCE Continued Access Protocol Active, not recruiting
A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2 Active, not recruiting
SPYRAL GEMINI Pilot Study Recruiting
A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening) Active, not recruiting
Longitudinal Real-world Clinical Outcomes Study on Symplicity Renal Denervation Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07090161 on ClinicalTrials.gov ↗ ← All trials in the USA