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Active, not recruiting Phase 1

Study Evaluating SC262 in Subjects With r/r Non-Hodgkin's Lymphoma (VIVID)

NCT06285422 · tracked via the Priya Life Science USA tracker
Phase
Phase 1
Started
2024-04-18
Last updated
2025-11-28

Condition(s) studied

Non Hodgkin's LymphomaLarge B-cell Lymphoma

Investigational drug(s) / intervention(s)

SC262 →

SC262: SC262 is an allogeneic CAR -T cell therapy

Study summary

SC262-101 is a Phase 1 study to evaluate SC262 safety and tolerability, anti-tumor activity, cellular kinetics, immunogenicity, and exploratory biomarkers.

Eligibility

Sex
ALL
Min age
18 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria: 1. Male or Female Subject aged 18-80 years at the time of signing the informed consent 2. Histologic diagnosis of NHL (based on World Health Organization 2016 criteria) including: * LBCL, including Diffuse Large B Cell Lymphoma (DLBCL) not otherwise specified (NOS) (including DLBCL arising from indolent lymphoma), Primary Mediastinal Large B-Cell Lymphoma (PMBCL), High-Grade B-Cell Lymphoma (HGBCL), and Follicular Lymphoma (FL) Grade 3B * FL * Marginal Zone Lymphomas (MZL) * Mantle Cell Lymphoma (MCL) 3. Relapsed or refractory disease after no more than 1 prior CD19-directed CAR T cell therapy 4. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1 5. At least 1 measurable (PET-positive) lesion per Lugano classification 6. Life expectancy ≥12 Weeks Exclusion Criteria: 1. Prior CD22-directed therapy including CD22-directed CAR T cell therapy or other CD22 -directed antibody or cell therapy (e.g., Natural Killer (NK) cell) 2. History of central nervous system (CNS) involvement of lymphoma within 1 year prior to enrollment. 3. Autologous hematopoietic stem cell transplantation (HSCT) within 3 months before treatment with Lymphodepleting (LD) chemotherapy (or allogeneic HSCT at any time) 4. Active autoimmune disease or any other diseases requiring immunosuppressive therapy or corticosteroid therapy (defined as \>10 mg/day prednisone or equivalent) 5. History or presence of CNS disorder, such as seizure disorder, cerebrovascular ischemia/hemorrhage, dementia, cerebellar disease, or any autoimmune disease with CNS involvement, within 12 months of enrollment.

Primary outcome measure(s)

  • Evaluate safety and tolerability of SC262 — 24 months
    Safety and Tolerability: Proportion of subjects experiencing adverse events and dose-limiting toxicities

Trial sites (3)

FacilityCityRegionStatus
The University of Kansas Hospital Kansas City Kansas
Swedish Cancer Institute Seattle Washington
Fred Hutchinson Cancer Center Seattle Washington
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06285422 on ClinicalTrials.gov ↗ ← All trials in the USA