Clinical Trials in the USA / NCT06285422
Active, not recruiting
Phase 1
Study Evaluating SC262 in Subjects With r/r Non-Hodgkin's Lymphoma (VIVID)
NCT06285422 · tracked via the Priya Life Science USA tracker
Condition(s) studied
Non Hodgkin's LymphomaLarge B-cell Lymphoma
Study summary
SC262-101 is a Phase 1 study to evaluate SC262 safety and tolerability, anti-tumor activity, cellular kinetics, immunogenicity, and exploratory biomarkers.
Eligibility
Inclusion Criteria:
1. Male or Female Subject aged 18-80 years at the time of signing the informed consent
2. Histologic diagnosis of NHL (based on World Health Organization 2016 criteria) including:
* LBCL, including Diffuse Large B Cell Lymphoma (DLBCL) not otherwise specified (NOS) (including DLBCL arising from indolent lymphoma), Primary Mediastinal Large B-Cell Lymphoma (PMBCL), High-Grade B-Cell Lymphoma (HGBCL), and Follicular Lymphoma (FL) Grade 3B
* FL
* Marginal Zone Lymphomas (MZL)
* Mantle Cell Lymphoma (MCL)
3. Relapsed or refractory disease after no more than 1 prior CD19-directed CAR T cell therapy
4. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1
5. At least 1 measurable (PET-positive) lesion per Lugano classification
6. Life expectancy ≥12 Weeks
Exclusion Criteria:
1. Prior CD22-directed therapy including CD22-directed CAR T cell therapy or other CD22 -directed antibody or cell therapy (e.g., Natural Killer (NK) cell)
2. History of central nervous system (CNS) involvement of lymphoma within 1 year prior to enrollment.
3. Autologous hematopoietic stem cell transplantation (HSCT) within 3 months before treatment with Lymphodepleting (LD) chemotherapy (or allogeneic HSCT at any time)
4. Active autoimmune disease or any other diseases requiring immunosuppressive therapy or corticosteroid therapy (defined as \>10 mg/day prednisone or equivalent)
5. History or presence of CNS disorder, such as seizure disorder, cerebrovascular ischemia/hemorrhage, dementia, cerebellar disease, or any autoimmune disease with CNS involvement, within 12 months of enrollment.
Primary outcome measure(s)
- Evaluate safety and tolerability of SC262 — 24 months
Safety and Tolerability: Proportion of subjects experiencing adverse events and dose-limiting toxicities
Trial sites (3)
| Facility | City | Region | Status |
|---|---|---|---|
| The University of Kansas Hospital | Kansas City | Kansas | |
| Swedish Cancer Institute | Seattle | Washington | |
| Fred Hutchinson Cancer Center | Seattle | Washington |
More Sana Biotechnology trials in the USA
Study Evaluating SC291 in Subjects With r/r B-cell Malignancies (ARDENT)
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Other trials for the same condition
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06285422 on ClinicalTrials.gov ↗ ← All trials in the USA