Creating a Global Research Database That Connects Genetic Information and Long-term Health Data to Improve Personalized Treatment for People With Serious Mental Illness
Not applicable- observational study: This is non-interventional, cross-sectional observational study and thus there is no intervention.
Study summary
This observational study aims to provide new insights into the nature and classification of severe mental illness and dementias that in time should help improve diagnostic practise, and enable the development of new and improved treatments. The investigators will achieve aims by gathering information and biological samples from over 50,000 research participants and then linking this information with participants' electronic health records, genetic and other potential markers of mental illnesses (called biomarkers, derived from biological samples). The investigators will use this resource to analyse how potential risk factors - genetic, other biological and non-biological (related to the participants' life circumstances) - influence participants' experiences, symptoms, and outcomes (both mental and physical health). The investigators will also use advanced analysis to assess whether there may be better ways of grouping together and understanding the experiences of those with severe mental illnesses and dementias. Given the value and importance of this resource for advancing mental health research, the investigators will also make the data available to other researchers to pursue these broad research aims.
Eligibility
Sex
ALL
Min age
18 Years
Max age
110 Years
Healthy volunteers
No
Inclusion Criteria:
\- All participants must have an electronic health record in a primary or secondary care service.
Mental Health cohort(s) • Have received a diagnosis and/or treatment/referral for mental illness for MDD, BD, Schizophrenia.
• Having an available electronic health record
• Current age 18+ (no upper age limit)
• Can speak English Dementia cohort
• Participants aged 18+ (no upper age limit)
• Currently alive and are, or have been, old age psychiatry patients
•
Received relevant diagnosis or referral:
EITHER
• Clinical diagnosis of dementia, mild cognitive impairment (MCI) or subjective cognitive impairment (SCI) OR
• Memory clinic referral
• Must be willing and able to complete a validated cognitive assessment (MoCA or SLUMS).
All dementia patients will undergo the extended biomarker analysis.
Exclusion Criteria:
\- Mental Health cohort(s)
• Patients without capacity to provide consent. Dementia cohort
• Inability to understand spoken and/or written spoken English
• Individuals with intellectual disability.
• Patients with dementia in Creutzfeldt-Jakob disease (CJD), Huntington's, HIV dementia, alcohol-related dementia, intellectual disability, traumatic brain injury at any time.
• Patients diagnosed with depression (only an exclusion criterion for MCI/SCI patients), psychosis, bipolar disorder prior in the pre-index period - to be checked at screening.
Primary outcome measure(s)
Diagnosis of participants with schizophrenia, bipolar disorder or schizoaffective disorder — 1 month from sample collection and baseline assessment. The primary outcome measure of this study is the diagnosis of participants with bipolar disorder, schizophrenia or schizoaffective disorder in accordance with ICD-10 criteria
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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