Clinical Trials in the UK 2026 — Live Industry Tracker

Age-Related Macular Degeneration, Age-related Macular Degeneration (ARMD), Intermediate AMD, Geographic Atrophy Secondary to Age-related Macular Degeneration
i-Lumen Scientific AUS PTY LTD · started 2025-05-07

📍 Belfast · London · Middlesex · Sunderland

NCT06662162 on ClinicalTrials.gov ↗

Recruiting Phase 1/Phase 2

Safety and Efficacy of VB10.16 and Pembrolizumab in Patients With Head-Neck Squamous Cell Carcinoma

HPV Positive Oropharyngeal Squamous Cell Carcinoma, HNSCC
Nykode Therapeutics ASA · started 2023-12-19

📍 London

NCT06016920 on ClinicalTrials.gov ↗

Active Phase 3

177Lu-PSMA-617 vs. Androgen Receptor-Directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer

Prostatic Neoplasms
Novartis Pharmaceuticals · started 2021-06-15

📍 Guildford · Sutton · Coventry · London · Middlesbrough

NCT04689828 on ClinicalTrials.gov ↗

Active Phase 3

Clinical Trial of Inhaled Molgramostim Nebulizer Solution in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)

Autoimmune Pulmonary Alveolar Proteinosis
Savara Inc. · started 2021-05-19

📍 London

NCT04544293 on ClinicalTrials.gov ↗

Starting soon Phase 3

A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma

Oropharyngeal Carcinoma (OPC)
Corbus Pharmaceuticals Inc. · started 2026-09-20

📍 London

NCT07768189 on ClinicalTrials.gov ↗

Recruiting

Real-World Study of Patients With Type 1 Diabetes Treated With Teplizumab as Part of Managed Access Programs (MAPs)

Type 1 Diabetes
Sanofi · started 2026-03-16

📍 Birmingham · London

NCT07457580 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

Major Depressive Disorder (MDD)
Draig Therapeutics Ltd · started 2025-12-16

📍 Chester · Eastbourne · Glasgow · London · Nottingham

NCT07300969 on ClinicalTrials.gov ↗

Recruiting Phase 2

Study to Evaluate the Efficacy, Safety, and Tolerability of PIPE 791 in Subjects With Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis
Contineum Therapeutics · started 2026-01-08

📍 Leicester · London · Southampton · Edinburgh · Perth

NCT07284459 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)

Urinary Bladder Neoplasms, Non-Muscle Invasive Bladder Neoplasms, Carcinoma in Situ
Merck Sharp & Dohme LLC · started 2025-03-11

📍 Glasgow · London · Torquay

NCT06833073 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)

Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC · started 2026-05-04

📍 London · Swansea

NCT07513376 on ClinicalTrials.gov ↗

Active Phase 2

A Study to Investigate Efficacy and Safety With Oral AZD9833 Compared With Intramuscular Fulvestrant in Post-menopausal Women at Least 18 Years of Age With Advanced ER-positive HER2 Negative Breast Cancer

Advanced ER-Positive HER2-Negative Breast Cancer
AstraZeneca · started 2020-04-22

📍 Derby · Leicester

NCT04214288 on ClinicalTrials.gov ↗

Active Phase 3

A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma

Melanoma
Bristol-Myers Squibb · started 2023-03-06

📍 London · Headington, Oxford · Newcastle upon Tyne

NCT05625399 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of Intravenous Immunoglobulin (IVIg) in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Chronic Inflammatory Demyelinating Polyneuropathy
Sanofi · started 2024-08-21

📍 London · Inverness · Oxford

NCT06290141 on ClinicalTrials.gov ↗

Recruiting Phase 1

A Phase I Study of BAY3498264 Given Together With Sotorasib in Participants Who Have Advanced Solid Cancers With Specific Genetic Changes Called KRASG12C Mutation

Advanced Solid Tumors Harboring KRAS G12C Mutation
Bayer · started 2024-11-08

📍 Manchester · Sutton

NCT06659341 on ClinicalTrials.gov ↗

Recruiting Phase 1

A Study to Investigate the Safety and Pharmacokinetics of Single- and Multiple-ascending Doses of AZD4916 in Healthy Volunteers

Healthy Participants
AstraZeneca · started 2026-07-23

📍 Harrow

NCT06951880 on ClinicalTrials.gov ↗

Active Phase 3

A Study to Learn About Medicine Called Ritlecitinib in Children Aged Between 6 to 12 Years With Severe Alopecia Areata

Severe Alopecia Areata
Pfizer · started 2025-07-31

📍 Brighton · London

NCT07029711 on ClinicalTrials.gov ↗

Active Phase 2

Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma

Synovial Sarcoma, Myxoid Liposarcoma
USWM CT, LLC · started 2019-08-13

📍 London · Manchester

NCT04044768 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease

Alzheimer's Disease
Bristol-Myers Squibb · started 2025-07-16

📍 Preston · Chertsey · Cambridge · London · Motherwell

NCT07011745 on ClinicalTrials.gov ↗

Recruiting

Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II

Refractory Angina
Shockwave Medical, Inc. · started 2022-01-04

📍 Basildon · Birmingham · Bristol · Cambridge · Dorchester

NCT05102019 on ClinicalTrials.gov ↗

Recruiting Phase 1/Phase 2

Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

Amyotrophic Lateral Sclerosis
Vector Y Therapeutics · started 2025-12-19

📍 London · Sheffield

NCT07287397 on ClinicalTrials.gov ↗

Active Phase 3

Durvalumab or Placebo in Combination With Gemcitabine/Cisplatin in Patients With 1st Line Advanced Biliary Tract Cancer (TOPAZ-1)

Biliary Tract Neoplasms
AstraZeneca · started 2019-04-16

📍 Bristol · Cambridge · London · Manchester · Oxford

NCT03875235 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease

COPD (Chronic Obstructive Pulmonary Disease)
AstraZeneca · started 2024-02-21

📍 Bicester · Bollington · Bradford · Cardiff · Chesterfield

NCT06283966 on ClinicalTrials.gov ↗

Active Phase 1

A Study of Runimotamab in Participants With Locally Advanced or Metastatic HER2-Expressing Cancers

Solid Tumors
Genentech, Inc. · started 2018-06-06

📍 Oxford

NCT03448042 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure

Chronic Kidney Disease and Hypertension
AstraZeneca · started 2025-03-03

📍 Bradford · Bristol · Canterbury · Cardiff · Dundee

NCT06742723 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

Major Depressive Disorder (MDD), Depression in Adults, Depression - Major Depressive Disorder, Depression Disorders
Cybin IRL Limited · started 2025-12-10

📍 Cambridge · Doncaster · Edinburgh · Glasgow · London

NCT06793397 on ClinicalTrials.gov ↗

Active Phase 3

A Study to Investigate Tolerability and Efficacy of Asciminib (Oral) Versus Nilotinib (Oral) in Adult Participants (≥18 Years of Age) With Newly Diagnosed Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in Chronic Phase (Ph+ CML-CP)

Philadelphia Chromosome-Positive Chronic Myeloid Leukemia
Novartis Pharmaceuticals · started 2022-11-21

📍 Glasgow · Gloucester · London · Newport

NCT05456191 on ClinicalTrials.gov ↗

Recruiting Phase 2/Phase 3

Phase 2/3 Study of Participants With Recurrent Pericarditis Evaluating the Efficacy and Safety of KPL-387

Pericarditis, Pericarditis Acute, Recurrent Pericarditis
Kiniksa Pharmaceuticals International, plc · started 2025-07-25

📍 London · Southampton

NCT07010159 on ClinicalTrials.gov ↗

Recruiting Phase 1/Phase 2

A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

Advanced Lung Cancer
BioNTech SE · started 2025-05-02

📍 Bristol · Leeds · Liverpool · London · Manchester

NCT06892548 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ - ColdU and SD)

Chronic Inducible Urticaria, Cold Urticaria, Cold-Induced Urticaria, Symptomatic Dermographism
Celldex Therapeutics · started 2026-01-15

📍 Cambridge · Glasgow · Manchester

NCT07266402 on ClinicalTrials.gov ↗

Active Phase 3

Study of Acalabrutinib (ACP-196) Versus Ibrutinib in Previously Treated Participants With High Risk Chronic Lymphocytic Leukemia (CLL)

Chronic Lymphocytic Leukemia
Acerta Pharma BV · started 2015-07-28

📍 Birmingham · Bournemouth · Cambridge · Cardiff · Greater London

NCT02477696 on ClinicalTrials.gov ↗

Recruiting Phase 2

Study of AHB-137 in Chronic Hepatitis B (CHB) Participants in North America and Europe Regions

Hepatitis B, Chronic
AusperBio Therapeutics Inc. · started 2026-08-27

📍 London

NCT07654283 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)

Early Alzheimer's Disease
Merck Sharp & Dohme LLC · started 2025-07-16

📍 Aberdeen · Edinburgh · Southampton · London · Oxford

NCT07033494 on ClinicalTrials.gov ↗

Active Phase 3

A Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Removal and Adjuvant Treatment With Nivolumab or Placebo for Participants With Surgically Removable Early Stage Non-small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung
Bristol-Myers Squibb · started 2019-11-05

📍 Taunton

NCT04025879 on ClinicalTrials.gov ↗

Recruiting

A Study to Understand How Cardiac Surgery-associated Acute Kidney Injury Develops in Participants Who Undergo Heart Surgery With the Use of Heart-lung Machine

Cardiac Surgery-associated Acute Kidney Injury
Bayer · started 2025-02-03

📍 Cambridge · Harefield · London

NCT06772025 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study to Find Out if Enfortumab Vedotin Given With Pembrolizumab Helps People With Muscle-invasive Bladder Cancer Keep Their Bladder

Muscle-invasive Bladder Cancer
Astellas Pharma Global Development, Inc. · started 2026-03-12

📍 London

NCT07475806 on ClinicalTrials.gov ↗

Active Phase 3

Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer With or Without Actionable Genomic Alterations (TROPION-LUNG01)

Non-small Cell Lung Cancer
Daiichi Sankyo · started 2020-12-21

📍 London · Manchester · Middlesbrough

NCT04656652 on ClinicalTrials.gov ↗

Active Phase 3

A Study to Assess Zipalertinib Versus Placebo in Participants With Early Stage NSCLC With Uncommon EGFR Mutations, Following Complete Tumor Resection

Lung Cancer, Adjuvant, Post-surgical, EGFR
Taiho Oncology, Inc. · started 2025-12-22

📍 Manchester · Nottingham · Torquay · Cardiff

NCT07128199 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDP

Chronic Inflammatory Demyelinating Polyneuropathy, CIDP, CIDP - Chronic Inflammatory Demyelinating Polyneuropathy
argenx · started 2025-08-22

📍 Salford · Leeds · London

NCT06920004 on ClinicalTrials.gov ↗

By invitation Phase 2

Open-Label, Long-Term, Extension Study of Infigratinib in Children With Hypochondroplasia

Hypochondroplasia
QED Therapeutics, a BridgeBio company · started 2026-04-23

📍 Manchester · Sheffield · Glasgow

NCT07393373 on ClinicalTrials.gov ↗

Recruiting Phase 2

Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD

Geographic Atrophy (GA), Age - Related Macular Degeneration (AMD)
ONL Therapeutics · started 2025-10-28

📍 Gloucester · London · Newcastle · Southampton · Sunderland

NCT06659445 on ClinicalTrials.gov ↗

Active Phase 2

Study to Evaluate Tulisokibart for Hidradenitis Suppurativa (MK-7240-012)

Hidradenitis Suppurativa
Merck Sharp & Dohme LLC · started 2025-06-09

📍 Dudley · London

NCT06956235 on ClinicalTrials.gov ↗

Recruiting Phase 3

Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)

Pancreatic Cancer, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Ductal Adenocarcinoma (PDAC)
Revolution Medicines, Inc. · started 2025-12-15

📍 Birmingham · Glasgow · London · Manchester

NCT07252232 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)

Rheumatoid Arthritis
Hoffmann-La Roche · started 2025-12-05

📍 Leicester · Doncaster · Newcastle upon Tyne · Barnet

NCT07137598 on ClinicalTrials.gov ↗

Recruiting Phase 2/Phase 3

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

Non-Small Cell Lung Cancer
Bristol-Myers Squibb · started 2025-11-05

📍 Glasgow · London · Sulton, Surrey

NCT07100080 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

Graves' Disease
Immunovant Sciences GmbH · started 2025-06-19

📍 Cornwell · London · Merthyr Tydfil · Salford · Surrey

NCT07018323 on ClinicalTrials.gov ↗

Recruiting Phase 3

Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC

Prostate Cancer
Novartis Pharmaceuticals · started 2025-07-01

📍 Sutton · London

NCT06855277 on ClinicalTrials.gov ↗

Recruiting Phase 3

Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

Non-small Cell Lung Cancer, Anaplastic Lymphoma Kinase-positive
Nuvalent Inc. · started 2025-07-17

📍 Cambridge · Guildford · Hampstead · London · Maidstone

NCT06765109 on ClinicalTrials.gov ↗

Recruiting Phase 3

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Solid Tumors, Hematologic Malignancies
Merck Sharp & Dohme LLC · started 2018-08-21

📍 Aberdeen · Cambridge · Edinburgh · Manchester · Sheffield

NCT03486873 on ClinicalTrials.gov ↗

Recruiting Phase 1

A Study of AIR-001 in Adults With Alpha-1 Antitrypsin Deficiency (AATD)

Alpha 1 Antitrypsin Deficiency
AIRNA Corporation · started 2026-03-17

📍 Cambridge · London · Southampton

NCT07431112 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study of Pasritamig With or Without JNJ-87189401 Versus Placebo for Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)

Metastatic Castration-resistant Prostatic Neoplasms
Janssen Research & Development, LLC · started 2025-09-02

📍 Birmingham · London · Manchester · Sutton

NCT07164443 on ClinicalTrials.gov ↗

Active

Anatomical Shoulder Domelock System Study

Avascular Necrosis, Revision Surgery, Conditions Consequent to Earlier Operations, Arthritis, Rheumatoid
Zimmer Biomet · started 2017-09-28

📍 Derby

NCT03312465 on ClinicalTrials.gov ↗

Starting soon Phase 3

A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes Mellitus and Obesity or Overweight

Obesity or Overweight, Diabetes Mellitus, Type 2
AstraZeneca · started 2026-08-21

📍 Chippenham · Corby · Dunfermline · Hull · Northwood

NCT07784270 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

Metastatic Colorectal Cancer
AbbVie · started 2025-04-24

📍 London · Oxford · Sutton · Manchester

NCT06820463 on ClinicalTrials.gov ↗

Active Phase 3

A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa

Hidradenitis Suppurativa (HS)
Incyte Corporation · started 2024-01-30

📍 Birmingham · Dudley · Salford

NCT06212999 on ClinicalTrials.gov ↗

Active

A Study About Antibody Levels and Biomarkers in the Blood in People With Late-onset Pompe Disease

Pompe Disease (Late-onset)
Astellas Gene Therapies · started 2024-02-01

📍 Cambridge · Newcastle upon Tyne · Salford

NCT06150820 on ClinicalTrials.gov ↗

Active Phase 2

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)

Breast Cancer, Cholangiocarcinoma, Colorectal Cancer, Head and Neck Neoplasms
Hoffmann-La Roche · started 2015-11-19

📍 Cambridge · London · Manchester

NCT02568267 on ClinicalTrials.gov ↗

Recruiting Phase 2/Phase 3

A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

Metastatic Non-small Cell Lung Cancer With MTAP Deletion
Bristol-Myers Squibb · started 2026-01-02

📍 Leicester · London

NCT07063745 on ClinicalTrials.gov ↗

Active Phase 1

Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors

Neoplasms
Tesaro, Inc. · started 2016-03-07

📍 Newcastle upon Tyne · Aberdeen · London · Manchester · Oxford

NCT02715284 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)

PIK3CA-Related Overgrowth Spectrum (PROS), Lymphatic Malformations, Vascular Malformations, PIK3CA Mutation
Relay Therapeutics, Inc. · started 2025-06-13

📍 London

NCT06789913 on ClinicalTrials.gov ↗

Active Phase 3

Acalabrutinib, Obinutuzumab and Chlorambucil in Treatment naïve CLL

Chronic Lymphocytic Leukemia
Acerta Pharma BV · started 2015-06-26

📍 Bournemouth · Cambridge · Leeds · Leicester · London

NCT02475681 on ClinicalTrials.gov ↗

Active Phase 4

Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics

Asthma
AstraZeneca · started 2019-10-08

📍 Cambridge · Headington · Leicester · Liverpool · London

NCT03953300 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

Age-related Macular Degeneration (AMD), Geographic Atrophy (GA)
Regeneron Pharmaceuticals · started 2024-10-30

📍 Liverpool · York · Bristol · London · Newcastle upon Tyne

NCT06541704 on ClinicalTrials.gov ↗

Recruiting Phase 1

An Open-label Study of AZD0120 in Adults With Multiple Sclerosis

Multiple Sclerosis
AstraZeneca · started 2025-12-09

📍 Cambridge · London

NCT07224373 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study of Pitolisant in Patients With Prader-Willi Syndrome

Prader-Willi Syndrome
Harmony Biosciences Management, Inc. · started 2024-05-28

📍 Cambridge · Hull · Dundee · Edinburgh

NCT06366464 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Trial Evaluating Brelovitug (BJT-778) vs Bulevirtide for the Treatment of Chronic Hepatitis Delta Infection (AZURE-2)

Chronic Hepatitis D Infection
Mirum Pharmaceuticals, Inc. · started 2025-08-27

📍 Birmingham · London · Manchester · Cottingham

NCT07200908 on ClinicalTrials.gov ↗

Recruiting Phase 3

Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

Amyotrophic Lateral Sclerosis
Prilenia · started 2026-02-01

📍 London · Stoke-on-Trent

NCT07322003 on ClinicalTrials.gov ↗

Recruiting Phase 2/Phase 3

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer
Mirati Therapeutics Inc. · started 2020-12-02

📍 Birmingham · Edinburgh · Kent · Leicester · London

NCT04613596 on ClinicalTrials.gov ↗

Active Phase 2

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis

Primary Biliary Cholangitis, PBC
Mirum Pharmaceuticals, Inc. · started 2021-09-22

📍 Southampton · Birmingham · Belfast · London · Newcastle upon Tyne

NCT05050136 on ClinicalTrials.gov ↗

By invitation

Recovery and Early Sleep Tracking Using the SuperPatch REM Patch

Shift Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder, Shift Work Sleep Disorders
SuperPatch Limited LLC · started 2026-05-15

📍 Birmingham

NCT07785960 on ClinicalTrials.gov ↗

Active Phase 3

A Study of Atezolizumab With Lenvatinib or Sorafenib Versus Lenvatinib or Sorafenib Alone in Hepatocellular Carcinoma Previously Treated With Atezolizumab and Bevacizumab

Unresectable Hepatocellular Carcinoma
Hoffmann-La Roche · started 2021-04-26

📍 Birmingham · Liverpool · London · Manchester · Newcastle upon Tyne

NCT04770896 on ClinicalTrials.gov ↗

Active

SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases
Medtronic Vascular · started 2021-10-20

📍 Oxford

NCT05198674 on ClinicalTrials.gov ↗

Active Phase 3

A Study to Evaluate Axatilimab Versus Best Available Therapy in Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy

Chronic Graft-versus-host-disease
Incyte Corporation · started 2025-06-04

📍 Cardiff · Glasgow · Leeds · Leicester · London

NCT06821542 on ClinicalTrials.gov ↗

Active Phase 2

A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489

Pulmonary Hypertension
Pfizer · started 2025-11-10

📍 London

NCT07073820 on ClinicalTrials.gov ↗

Recruiting Phase 1

A Study to Evaluate Safety, Pharmacokinetics, and Activity of GDC-7035 as a Single Agent and in Combination in Patients With Advanced Solid Tumors

Solid Tumor
Genentech, Inc. · started 2024-11-14

📍 Edinburgh · London · Manchester · Sutton

NCT06619587 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults

Diabetes Mellitus, Type 1
Eli Lilly and Company · started 2026-01-12

📍 Birmingham · Cambridge · Cardiff · Glasgow · London

NCT07222137 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)

Chronic Graft-versus-host-disease
Incyte Corporation · started 2026-05-20

📍 Birmingham · Cambridge · Glasgow · Leeds · London

NCT07124078 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

Graves' Disease
Immunovant Sciences GmbH · started 2024-12-17

📍 Birmingham · Bristol · Coventry · London · Cambridge

NCT06727604 on ClinicalTrials.gov ↗

Recruiting

A Non-interventional Study of Participants With BPDCN Treated With Chemotherapy

Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Stemline Therapeutics, Inc. · started 2025-10-17

📍 London · Oxford

NCT07785180 on ClinicalTrials.gov ↗

Recruiting Phase 2/Phase 3

Study to Evaluate Switching to Brelovitug for the Treatment of CHD in Participants Receiving Bulevirtide

Chronic Hepatitis D
Mirum Pharmaceuticals, Inc. · started 2026-02-26

📍 Cottingham · Cardiff · London · Manchester

NCT07454837 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

Metastatic Breast Cancer
Hoffmann-La Roche · started 2023-09-08

📍 Belfast · Blackpool · Colchester, Essex · Northwood · Nottingham

NCT05894239 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities

Obesity, Overweight
Eli Lilly and Company · started 2024-11-18

📍 Barnsley · Dundee · Hull

NCT06672939 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.

Metastatic Castration-Resistant Prostate Cancer
Pfizer · started 2024-10-22

📍 Blackburn · Chelmsford · Derby · Glasgow · Metropolitan Borough of Wirral

NCT06629779 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib

Myelofibrosis, Anemia
Takeda · started 2026-09-02

📍 Lincoln · Leicester · London · Sunderland · Birmingham

NCT07623161 on ClinicalTrials.gov ↗

Recruiting Phase 1

Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Prostate Cancer

Hormone-refractory Prostate Cancer
Astellas Pharma Global Development, Inc. · started 2023-08-10

📍 London

NCT05997615 on ClinicalTrials.gov ↗

Starting soon

An Investigation Into Dielectric Testing for the Evaluation and Characterisation of Breast Tissue Using a Novel Time-Domain Bioimpedance Tool

Breast Cancer, Breast - Female
Zedsen Limited · started 2026-09

📍 London

NCT07782814 on ClinicalTrials.gov ↗

Recruiting Phase 2/Phase 3

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

Macular Degeneration, Age-Related Macular Degeneration, Choroidal Neovascularization, Wet Macular Degeneration
EyeBiotech Ltd. · started 2026-03-27

📍 Leicester · London

NCT07440225 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis

Ulcerative Colitis
AbbVie · started 2025-07-28

📍 Cambridge · Sheffield · Liverpool

NCT07071519 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

Metastatic Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
BeOne Medicines · started 2025-08-27

📍 Cambridge · Dundee · Metropolitan Borough of Wirral

NCT07043400 on ClinicalTrials.gov ↗

Recruiting Phase 1

Study of Lunresertib Alone or in Combination With RP-3500 or Debio 0123 in Patients With Advanced Solid Tumors

Advanced Solid Tumor
Debiopharm International SA · started 2021-04-30

📍 London

NCT04855656 on ClinicalTrials.gov ↗

Active Phase 2

Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer

Hepatocellular Carcinoma, Biliary Tract Cancer
AstraZeneca · started 2023-04-24

📍 Cambridge · London · Manchester

NCT05775159 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Phase 3 Study to Evaluate the Safety and Efficacy of AOC 1044 (Also Referred to as Delpacibart Zotadirsen) in Participants With DMD With Gene Mutations Amenable to Exon 44 Skipping

Muscular Dystrophies, Muscular Dystrophies (Duchenne, Becker, Myotonic Dystrophy), Muscular Disorders, Atrophic, Muscular Disease
Avidity Biosciences, Inc. · started 2026-08

📍 Newcastle

NCT07587242 on ClinicalTrials.gov ↗

Recruiting Phase 2

SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes

Type 1 Diabetes
SAb Biotherapeutics, Inc. · started 2025-11-25

📍 Cambridge · Cardiff · Edinburgh · Liverpool · London

NCT07187531 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034)

Carcinoma, Renal Cell
Merck Sharp & Dohme LLC · started 2026-04-09

📍 Withington

NCT07489495 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)

Cervical Cancer
Merck Sharp & Dohme LLC · started 2026-01-19

📍 Edinburgh · Withington

NCT07216703 on ClinicalTrials.gov ↗

Active

PASS of Paediatric Patients Initiating Selumetinib

Neurofibromatosis Type 1
AstraZeneca · started 2022-05-23

📍 London · Manchester · Newcastle upon Tyne

NCT05388370 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

Breast Neoplasms, Triple Negative Breast Neoplasms, HR Low-Positive/HER2-Negative Breast Neoplasms
Merck Sharp & Dohme LLC · started 2025-06-30

📍 London · Dundee · Huddersfield · Colchester · Orpington

NCT06966700 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acromegaly Previously Treated With Somatostatin Analogs

Acromegaly
Debiopharm International SA · started 2025-11-26

📍 Birmingham · Leeds

NCT06930625 on ClinicalTrials.gov ↗

Active Phase 3

Determine Effectiveness of Anifrolumab In SYstemic Sclerosis (DAISY)

Systemic Sclerosis, Scleroderma
AstraZeneca · started 2023-11-08

📍 Cannock · Leeds · London · Sheffield

NCT05925803 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)

Malignant Neoplasm
Merck Sharp & Dohme LLC · started 2025-08-11

📍 East Sussex · Truro · London · Edinburgh · Birmingham

NCT06979596 on ClinicalTrials.gov ↗

Recruiting Phase 3

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung
Eli Lilly and Company · started 2025-03-27

📍 Birmingham · East Sussex · Huddersfield · London · Manchester

NCT06890598 on ClinicalTrials.gov ↗

Recruiting Phase 3

BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies

Healthy
Pfizer · started 2025-08-25

📍 Bristol · London · Truro · Southampton · Manchester

NCT07160244 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostatic Neoplasms
Merck Sharp & Dohme LLC · started 2023-12-18

📍 Cambridge · Derby · Torquay · Northwood · Truro

NCT06136650 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

Ulcerative Colitis, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases, Crohn's Disease
Eli Lilly and Company · started 2021-05-26

📍 London · Oxford · Sheffield

NCT04844606 on ClinicalTrials.gov ↗

Recruiting Phase 1

Investigating the Effect of Itraconazole on the Pharmacokinetics of AZD4144 in Healthy Participants

Healthy
AstraZeneca · started 2026-07-30

📍 Harrow

NCT07685600 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

Breast Neoplasms
Merck Sharp & Dohme LLC · started 2025-07-21

📍 London · Leicester · Manchester

NCT07060807 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Eli Lilly and Company · started 2024-04-29

📍 Bristol · Chelsea · Great Yarmouth · London · Newcastle upon Tyne

NCT06338995 on ClinicalTrials.gov ↗

Recruiting

BoStOn SCientific Rhythm MAnagemenT REgiStry

Cardiac Disease
Boston Scientific Corporation · started 2021-03-31

📍 London · Manchester

NCT04823663 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study of LY4005130 in Adult Participants With Severe Alopecia Areata (Hair Loss)

Alopecia Areata
Eli Lilly and Company · started 2026-04-14

📍 London · Salford

NCT07533006 on ClinicalTrials.gov ↗

Recruiting Phase 3

Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043)

Von Hippel-Lindau Disease, Malignant Neoplasms
Merck Sharp & Dohme LLC · started 2026-03-23

📍 Glasgow · London · Manchester

NCT07405164 on ClinicalTrials.gov ↗

Recruiting Phase 1

A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Adult and Pediatric Participants With Spinal Muscular Atrophy (PIERRE-PK)

Muscular Atrophy, Spinal
Biogen · started 2025-01-16

📍 Sheffield

NCT06555419 on ClinicalTrials.gov ↗

Recruiting Phase 2

Study of ABBV-142 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis
AbbVie · started 2026-01-23

📍 Cambridge · Edinburgh · London · Southampton · Norwich

NCT07230288 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031)

Bladder Cancer
Merck Sharp & Dohme LLC · started 2026-04-23

📍 Cambridge

NCT07419295 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study of Tacabrutideg (BGB-16673) Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors

CLL, Chronic Lymphocytic Leukemia
BeOne Medicines · started 2025-04-10

📍 Aberdeen · Birmingham · Bournemouth · London · Southampton

NCT06846671 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study of Zasocitinib (TAK-279) in Adults With Active Crohn's Disease

Crohn's Disease
Takeda · started 2026-08-13

📍 Oxford

NCT07403968 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)

Obesity, Overweight
Eli Lilly and Company · started 2024-11-18

📍 Barnsley · Bristol · Cambridge · Dundee · Harrow

NCT06672549 on ClinicalTrials.gov ↗

Active Phase 1

AZD6244 (ARRY-142886) Solid Oral Dosage Formulation in Participants With Advanced Solid Malignancies

Tumor, Cancer
AstraZeneca · started 2007-03-08

📍 Sutton

NCT00463814 on ClinicalTrials.gov ↗

Recruiting Phase 2

Obe-cel in Severe, Refractory Systemic Lupus Erythematosus (SLE) With Active Lupus Nephritis (LN)

Lupus Nephritis
Autolus Limited · started 2026-01-16

📍 Birmingham · Bristol · Cambridge · Edinburgh · Glasgow

NCT07053800 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)

Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
Merck Sharp & Dohme LLC · started 2025-04-09

📍 Cambridge · Edinburgh · Preston · London · Sutton

NCT06824467 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)

Atherosclerosis Cardiovascular Disease, Chronic Kidney Disease
Eli Lilly and Company · started 2025-12-01

📍 Birmingham · Blackpool · Bromborough · Newcastle · Newquay

NCT07241390 on ClinicalTrials.gov ↗

Recruiting Phase 1

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

Metastatic Solid Tumor, Recurrent Solid Tumor, Advanced Solid Tumor, Urinary Bladder Neoplasm
Eli Lilly and Company · started 2024-07-01

📍 London · Manchester

NCT06465069 on ClinicalTrials.gov ↗

Recruiting Phase 3

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

Non-Small Cell Lung Cancer
Summit Therapeutics · started 2023-10-26

📍 Leeds · London · Manchester

NCT05899608 on ClinicalTrials.gov ↗

Starting soon

A Postmarketing Study of LEQEMBI in United Kingdom (UK) Participants With Alzheimer's Disease (AD)

Alzheimers Disease
Eisai Limited · started 2026-08-31

📍 Edinburgh · London · Motherwell

NCT07781345 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study of TYRA-300 in Children With Achondroplasia: BEACH301

Achondroplasia
Tyra Biosciences, Inc · started 2025-03-04

📍 London · Sheffield

NCT06842355 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease

Crohn's Disease
Eli Lilly and Company · started 2024-03-13

📍 Edinburgh · Headington · London · Manchester · Sheffield

NCT05509777 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study of How the Medicine Called "Etrasimod" Works in Children With the Gut Disease Called Ulcerative Colitis

Colitis, Ulcerative
Pfizer · started 2026-05-28

📍 London · Bristol · Liverpool · Sheffield

NCT07470879 on ClinicalTrials.gov ↗

Active Phase 3

A Phase-3, Open-Label, Randomized Study of Dato-DXd Versus Investigator's Choice of Chemotherapy (ICC) in Participants With Inoperable or Metastatic HR-Positive, HER2-Negative Breast Cancer Who Have Been Treated With One or Two Prior Lines of Systemic Chemotherapy (TROPION-Breast01)

Breast Cancer
AstraZeneca · started 2021-10-18

📍 Blackpool · Bristol · Cardiff · Colchester · Edinburgh

NCT05104866 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine

Episodic Migraine
AbbVie · started 2023-05-01

📍 London · Gillingham · Aberdeen · Stockport

NCT05711394 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome

Dravet Syndrome
Stoke Therapeutics, Inc · started 2025-06-04

📍 Glasgow · London · Sheffield

NCT06872125 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study of Baricitinib in Participants From 1 Year to Less Than 18 Years Old With Juvenile Idiopathic Arthritis

Juvenile Idiopathic Arthritis
Eli Lilly and Company · started 2019-04-05

📍 Bristol · Liverpool · London · Oxford · Sheffield

NCT03773965 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Constipation (IBS-C)

Irritable Bowel Syndrome, Constipation
Eli Lilly and Company · started 2026-04-29

📍 Cheadle · Hounslow · Macclesfield · Newcastle upon Tyne · Newquay

NCT07545772 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments

Multiple Myeloma
Pfizer · started 2021-10-04

📍 Bournemouth · Oxford · Cardiff · Bristol · Canterbury

NCT05020236 on ClinicalTrials.gov ↗

Active Phase 3

The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
Eli Lilly and Company · started 2024-04-30

📍 Aberdeen · Birmingham · Bromborough · Coventry · Glasgow

NCT06383390 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years

Chronic Migraine
AbbVie · started 2025-02-13

📍 London · Gillingham · Aberdeen · Stockport

NCT06810505 on ClinicalTrials.gov ↗

Recruiting Phase 3

Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)

Prostate Cancer Metastatic
Merck Sharp & Dohme LLC · started 2023-12-31

📍 Cambridge · Truro · Glasgow · London · Manchester

NCT06136624 on ClinicalTrials.gov ↗

Recruiting Phase 1/Phase 2

A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma

Relapsed/Refractory Multiple Myeloma
BeOne Medicines · started 2021-09-16

📍 Headington · London · Sutton · Truro

NCT04973605 on ClinicalTrials.gov ↗

Recruiting Phase 2/Phase 3

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

Cachexia, Metastatic Pancreatic Ductal Adenocarcinoma
Pfizer · started 2025-10-03

📍 Cambridge · London · Edinburgh · Liverpool

NCT06989437 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study of Belumosudil in Children With Chronic Graft Versus Host Disease (schoolROCK)

Chronic Graft Versus Host Disease
Sanofi · started 2025-12-02

📍 Newcastle upon Tyne · London

NCT07116031 on ClinicalTrials.gov ↗

Active Phase 3

A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a)
Eli Lilly and Company · started 2024-03-05

📍 Blackpool · Bristol · Cheadle · Enfield · Glasgow

NCT06292013 on ClinicalTrials.gov ↗

Recruiting Phase 4

A Study to Investigate the Effect of Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler (BGF MDI) Compared With Placebo MDI on Heart and Lung Function in Participants With Chronic Obstructive Pulmonary Disease (COPD) and Hyperinflation

Chronic Obstructive Pulmonary Disease, Hyperinflation
AstraZeneca · started 2025-11-24

📍 Harefield · London · Manchester

NCT07073950 on ClinicalTrials.gov ↗

Recruiting Phase 1

A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease

Alzheimer Disease
Eli Lilly and Company · started 2024-08-15

📍 London · Sheffield · Southampton

NCT06297590 on ClinicalTrials.gov ↗

Recruiting Phase 3

MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)

Multiple Myeloma
Pfizer · started 2024-02-08

📍 Milton Keynes · Bodelwyddan · Bournemouth · Poole · Eastbourne

NCT06152575 on ClinicalTrials.gov ↗

Starting soon Phase 2

A Study of Brenipatide (LY3537031) in Adult Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive
Eli Lilly and Company · started 2026-08

📍 Cheadle · Ely · Hounslow · London · Penzance

NCT07759245 on ClinicalTrials.gov ↗

Recruiting Phase 2

A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Diarrhea (IBS-D)

Irritable Bowel Syndrome, Diarrhea
Eli Lilly and Company · started 2026-05-06

📍 Cheadle · Hounslow · Macclesfield · Newcastle upon Tyne · Newquay

NCT07545759 on ClinicalTrials.gov ↗

Recruiting Phase 3

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis
Eli Lilly and Company · started 2023-12-21

📍 Aberdeen · Dundee · Huddersfield · Leeds · Manchester

NCT06119581 on ClinicalTrials.gov ↗

Active

A Study to Learn About the Effectiveness of Etrasimod in People With Ulcerative Colitis

Colitis, Ulcerative
Pfizer · started 2024-05-08

📍 Glasgow · Nottingham · Oxford · Edinburgh · Crumpsall

NCT06294925 on ClinicalTrials.gov ↗

Clinical Trials in the UK

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