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Clinical Trials in Turkey / NCT07867314
Active, not recruiting Not applicable

Effect of Apical Patency on Periapical Lesion Healing

NCT07867314 · tracked via the Priya Life Science Turkey tracker
Sponsor
Recep Tayyip Erdogan University
Phase
Not applicable
Started
2025-05-22
Last updated
2026-10-09

Condition(s) studied

Periapical LesionApical PeriodontitisDental Pulp NecrosesMouth DiseasesPeriapical Diseases

Investigational drug(s) / intervention(s)

Apical Patency During Root Canal TreatmentRoot Canal Treatment Without Apical Patency

Apical Patency During Root Canal Treatment: A #10 stainless-steel K-file was passively advanced approximately 0.5-1 mm beyond the working length after each rotary instrument during standardized single-visit root canal treatment.

Root Canal Treatment Without Apical Patency: Standardized single-visit root canal treatment was performed with instrumentation confined to the working length and without intentional passage of an instrument beyond the apical foramen.

Study summary

This non-randomized clinical study aims to evaluate the effect of apical patency during root canal treatment on the healing of periapical lesions in maxillary anterior teeth. Participants will be assigned to either an apical patency group or a non-patency group. Changes in periapical lesion volume will be assessed using cone-beam computed tomography (CBCT) one year after treatment. The study aims to provide an objective volumetric assessment of the potential contribution of apical patency to periapical healing.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Adult patients. * Systemically healthy and not using regular systemic medications. * A single-rooted maxillary anterior tooth requiring primary root canal treatment. * Diagnosis of chronic apical periodontitis in the study tooth. * The tooth was restorable. * Absence of root fracture or crack. * Absence of internal or external resorption. * Root canal negotiable to the apical region with a small hand file. * Ability to establish a reliable working length. * Availability of a CBCT scan of the relevant maxillary anterior region, previously obtained for clinical purposes or indicated during the treatment process. Exclusion Criteria: * Pregnancy or breastfeeding. * Previous endodontic treatment of the study tooth. * Severe canal calcification. * Suspected root fracture or crack. * Internal or external root resorption. * Periodontal probing depth of 5 mm or greater. * Previous surgical intervention in the relevant region. * Inability to negotiate the root canal. * Inability to establish a reliable working length.

Primary outcome measure(s)

  • Change in periapical lesion volume — Before root canal treatment and at 1 year after treatment
    Periapical lesion volume was measured in cubic millimeters (mm³) on clinically indicated pre-treatment CBCT scans using manual three-dimensional segmentation with ITK-SNAP software. One baseline lesion-volume value was obtained for each participant with an evaluable CBCT scan

Trial sites (1)

FacilityCityRegionStatus
Recep Tayyip Erdogan University Faculty of Dentistry, Department of Endodontics Rize Rize Province

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Other trials for the same condition

Biomarkers in Apical Periodontitis Starting soon
Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial) Recruiting
Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment Recruiting
The Success of Root Canal Treatments Performed Using Two Different Intracanal Medicaments Active, not recruiting
Antibacterial Activity of Calcium Hydroxide and Betamethasone in Apical Periodontitis Starting soon
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07867314 on ClinicalTrials.gov ↗ ← All trials in Turkey