Hyperoxemia and Oxygen Reserve Index During Neurointerventional Anesthesia

Condition(s) studied

Investigational drug(s) / intervention(s)

Oxygen Reserve Index Monitoring (Observational): Non-invasive ORi measurement via multi-wavelength pulse co-oximetry, recorded blinded to the anesthesia team and not used to guide care.

Study summary

The goal of this observational study is to learn how often high blood oxygen levels (hyperoxemia) occur in adults receiving general anesthesia for planned (elective) neurointerventional procedures, such as brain aneurysm coiling or other catheter-based treatments of brain vessels. It will also look at how well a non-invasive finger sensor measurement called the Oxygen Reserve Index (ORi) reflects arterial oxygen levels.

The main questions it aims to answer are:

* How often is the arterial oxygen pressure (PaO2) 150 mmHg or higher in blood gas samples taken as part of routine care during these procedures?
* How does ORi relate to PaO2, and can ORi help identify high oxygen levels?

Participants will:

* Receive anesthesia and their procedure exactly as planned by their care team; the study does not change any treatment, oxygen setting, or ventilator setting.
* Have a painless ORi sensor placed on a finger, similar to a standard pulse oximeter, during anesthesia.
* Have their routine monitoring values and the results of arterial blood gas samples taken for routine clinical care recorded.

No extra blood samples will be taken for the study, and ORi values will not be used to guide care.

Eligibility

Primary outcome measure(s)

• Proportion of Matched Arterial Blood Gas Measurements With PaO2 >=150 mmHg — Intraoperative period, from intubation to the end of the procedure before FiO2 is increased for emergence (approximately 1-4 hours)
  Number of valid matched ORi-PaO2 measurement pairs with PaO2 \>=150 mmHg divided by the total number of valid matched pairs, multiplied by 100. Only arterial blood gas samples drawn for routine clinical care and matched to a valid ORi value recorded at the time of sampling or within 1 minute are included. Reported with 95% confidence interval.

Trial sites (1)

More Fatih Sultan Mehmet Training and Research Hospital trials in Turkey

Other trials for the same condition