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Clinical Trials in Turkey / NCT07648277
Recruiting Observational

Spinal Alignment, Spinal Mobility, and Balance in Patients With Multiple Sclerosis

NCT07648277 · tracked via the Priya Life Science Turkey tracker
Sponsor
Ankara Yildirim Beyazıt University
Phase
Observational
Started
2026-02-01
Last updated
2026-06-15

Condition(s) studied

Multiple SclerosisBalance

Study summary

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system characterized by demyelination and axonal degeneration. Neuromuscular impairments associated with MS, including muscle weakness, spasticity, fatigue, and proprioceptive deficits, may lead to alterations in spinal posture and reduced spinal mobility. These changes can negatively affect trunk control, balance, respiratory function, and functional independence.

Although postural abnormalities and mobility limitations have been reported in individuals with MS, the relationship between spinal posture, spinal mobility, and balance remains insufficiently investigated. Therefore, this study aims to examine the associations between spinal posture, spinal mobility, and balance performance in individuals with multiple sclerosis. Improved understanding of these relationships may contribute to the development of targeted rehabilitation interventions aimed at enhancing postural control and functional outcomes in this population. This study further hypothesises that alterations in spinal posture and spinal mobility are associated with impaired balance performance in individuals with multiple sclerosis.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Diagnosis of relapsing-remitting multiple sclerosis (RRMS) * Aged between 18 and 65 years * EDSS score between 0.5 and 4.5 * Standardized Mini-Mental State Examination score ≥24 Exclusion Criteria: * Receipt of corticosteroid treatment within the previous 4 weeks * Presence of any additional neurological disorder * Spasticity defined as a Modified Ashworth Scale score ≥3 * History of surgical intervention involving the lower extremities, spine, or abdominal region

Primary outcome measure(s)

  • Spinal alignment — 1 hour
    Spinal alignment was assessed in the sagittal and frontal planes during neutral standing, maximal trunk flexion, and maximal trunk extension. All spinal alignment parameters were recorded as angular values and expressed in degrees (°).
  • Spinal mobility — 1 hour
    Spinal mobility was assessed in both the sagittal and frontal planes. In the sagittal plane, mobility was calculated as the angular difference between the neutral standing posture and maximal trunk flexion and extension positions. In the frontal plane, lateral flexion mobility was calculated as the angular difference between the neutral standing posture and maximal right and left lateral flexion positions. All measurements were recorded in degrees (°).

Trial sites (1)

FacilityCityRegionStatus
Ankara Yıldırım Beyazıt University Ankara Çubuk Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07648277 on ClinicalTrials.gov ↗ ← All trials in Turkey