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Clinical Trials in Turkey / NCT07575555
Recruiting Observational

The Effect of Lipedema on Knee Osteoarthritis

NCT07575555 · tracked via the Priya Life Science Turkey tracker
Sponsor
Izmir Democracy University
Phase
Observational
Started
2026-07-07
Last updated
2026-07-09

Condition(s) studied

LipedemaKnee OsteoarthritisKnee Acute and Chronic PainKneeKnee Arthritis OsteoarthritisKnee ArthropathyKnee Cartilage DefectsKnee Cartilage Lesions

Study summary

This study will be one of the few to examine the effect of lipedema on knee osteoarthritis in a comparative manner with a control group within the same osteoarthritis context. Although the relationship between obesity and osteoarthritis has been extensively studied in the literature, the effect of specific adipose tissue pathologies, such as lipedema, on osteoarthritis has not been sufficiently investigated. This study aims to demonstrate the independent effect of lipedema on osteoarthritis, evaluate clinical and ultrasonographic parameters together, and contribute to early diagnosis and targeted rehabilitation strategies.

Eligibility

Sex
FEMALE
Min age
30 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria: All participants (Group 1 + Group 2) * Women aged 30-65 * With a clinical and radiological diagnosis of knee osteoarthritis * Who agreed to participate in the study Group 1 (knee osteoarthritis with lipedema): * Patients who meet the Wold criteria for a clinical diagnosis of lipedema * An increase in subcutaneous fat thickness confirmed by ultrasound Group 2 (knee osteoarthritis without lipedema): * No diagnosis of lipedema * Exclusion of lymphedema and venous diseases Exclusion Criteria: * Inflammatory arthritis * History of knee surgery * Intra-articular injection within the past 6 months * Acute trauma * Systemic connective tissue disease * Severe venous insufficiency or lymphedema * History of malignancy * Use of gabapentinoids/SNRIs/SSRIs due to fibromyalgia or psychiatric illness * Severe cognitive impairment or communication problems that would prevent participation in the study * Pregnancy * Participants who were informed about the study and refused to participate

Primary outcome measure(s)

  • Ultrasonography-based measurements of femoral cartilage thickness — Day 1
    During femoral cartilage thickness measurements, participants will be positioned in the supine position, and the knee will be brought to maximum flexion for evaluation through the suprapatellar window. The probe will be positioned in the transverse plane, and measurements will be taken at the level of the medial and lateral femoral condyles and the intercondylar groove. For standardization, each measurement will be repeated three times, and the average will be recorded. Cartilage thickness will be defined as the distance between the hypoechoic cartilage layer and the subchondral bone surface. Lower values indicate that osteoarthritis has caused more structural damage.

Trial sites (2)

FacilityCityRegionStatus
Izmir Democracy University Izmir İzmir Not Yet Recruiting
Izmir Democracy University Izmir İzmir Recruiting

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Other trials for the same condition

Investigation of Medial Longitudinal Arch and Foot Function in Patients With Lipedema Recruiting
Oral vs Intravenous Dexamethasone in Total Knee Arthroplasty Recruiting
Transcutaneous Auricular Vagus Nerve Stimulation-Enriched Rehabilitation in Individuals With Lipedema Recruiting
Efficacy of Complex Decongestive Therapy, Exercise and Diet in Women With Lipedema Starting soon
Low-Level Laser Therapy in Knee Osteoarthritis: Effects on Clinical Outcomes, Femoral Cartilage Thickness and Regional Sarcopenia Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07575555 on ClinicalTrials.gov ↗ ← All trials in Turkey