Lipedema is a chronic adipose tissue disorder that commonly leads to joint laxity, hypermobility, and functional limitations, yet its impact on foot morphology has not been systematically examined. This case-control study aims to investigate whether patients with lipedema exhibit a higher prevalence of generalized joint hypermobility and foot structural abnormalities-specifically pes planus-compared with age- and BMI-matched controls. Using radiographic measurements (Meary angle and calcaneal inclination angle), clinical hypermobility assessment, and validated functional scales, the study seeks to determine the relationship between lipedema, hypermobility, and foot function.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
General Inclusion Criteria (Apply to All Participants)
* Female participants
* Age 18 years or older
* Able to read and write (literacy requirement)
* Availability of bilateral lateral foot radiographs obtained within the past 1 year in the hospital PACS system
* Willing and able to provide written and verbal informed consent
Additional eligibility criteria for Lipedema Group
\- Clinical diagnosis of lipedema according to Halk and Damstra criteria.
Additional eligibility criteria for Control group:
* Female patients presenting with nonspecific foot pain
* Similar age and BMI range as the lipedema group
* No clinical diagnosis or suspicion of lipedema
Exclusion Criteria (Apply to all participants)
* Pregnancy
* Illiteracy
* Inability or unwillingness to provide written and verbal informed consent
* History of lower extremity fracture, trauma, or orthopedic surgery
* Diagnosis of diabetes mellitus
* Known rheumatologic disease
* Known polyneuropathy or peripheral nerve injury affecting the lower extremities
Primary outcome measure(s)
Meary angle (Degrees) — Day 1 The Meary angle (talo-first metatarsal angle) will be measured on standardized lateral foot radiographs to evaluate medial longitudinal arch alignment. Increased angles indicate midfoot collapse and are used to identify pes planus. Higher values represent greater deviation from normal alignment.
Calcaneal Inclination Angle (Degrees) — Day 1 The calcaneal inclination angle will be measured on lateral foot radiographs to assess arch height. Lower angles indicate reduced arch height, consistent with pes planus. Measurements are obtained using established radiographic guidelines.
Trial sites (1)
Facility
City
Region
Status
Marmara University Pendik Training and Research Hospital
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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