Assessment of Venous Insufficiency and Clinical Features in Lipedema

Condition(s) studied

Investigational drug(s) / intervention(s)

Venous Doppler Ultrasonography: Participants will undergo lower extremity venous Doppler ultrasonography to evaluate venous insufficiency findings, including venous reflux characteristics, affected venous segments, and venous diameters in the superficial and deep venous systems.

Numeric Rating Scale: Pain intensity will be evaluated using the Numeric Rating Scale, ranging from 0 (no pain) to 10 (worst imaginable pain).

Lower Extremity Functional Scale: Functional status will be assessed using the Lower Extremity Functional Scale. The total score ranges from 0 to 80, with higher scores indicating better lower extremity function and lower disability levels.

Short Form-12: Health-related quality of life will be assessed using the SF-12 questionnaire, including the Physical Component Summary (PCS-12) and Mental Component Summary (MCS-12) scores. Scores range from 0 to 100, with higher scores indicating better perceived health status and quality of life.

Lower Extremity Circumference at Standardized Anatomical Landmarks (cm): Circumference of both lower extremities will be measured using a non-stretch tape measure at the ankle, calf, knee, and thigh according to standardized anatomical landmarks. Measurements will be recorded in centimeters.

Clinical Staging: Lipedema stage will be determined according to clinical examination findings and established diagnostic criteria.

Study summary

Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, tenderness, edema, and functional impairment. Venous symptoms such as heaviness, swelling, and discomfort are frequently reported in individuals with lipedema; however, the relationship between venous Doppler ultrasonography findings and lipedema-related clinical manifestations remains insufficiently investigated. This cross-sectional controlled study aims to evaluate venous insufficiency parameters in patients with lipedema using Doppler ultrasonography and to examine their associations with pain severity, lower extremity function, disease severity, and quality of life.

Eligibility

Primary outcome measure(s)

• Presence of Venous Reflux on Doppler Ultrasonography — Baseline
  Venous reflux will be assessed using lower extremity venous Doppler ultrasonography. The presence of pathological reflux in great saphenous vein will be recorded according to standard venous ultrasound criteria.

Trial sites (1)

More Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey trials in Turkey

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