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Clinical Trials in Turkey / NCT07415161
Starting soon Not applicable

Oxygen Reserve Index (ORi) in Identifying Desaturation

NCT07415161 · tracked via the Priya Life Science Turkey tracker
Sponsor
Istanbul University
Phase
Not applicable
Started
2026-01-27
Last updated
2026-02-17

Condition(s) studied

Apneic OxygenationEndolarengeal SurgeryOxygen Reserve Index

Investigational drug(s) / intervention(s)

oxygen monitoring techniques

oxygen monitoring techniques: to determine whether ORi monitoring provides earlier and clinically meaningful warning of oxygen reserve depletion compared with conventional pulse oximetry, potentially improving patient safety during shared-airway surgery.

Study summary

This randomized clinical trial investigates whether Oxygen Reserve Index (ORi) monitoring enables earlier detection of impending hypoxemia compared with conventional pulse oximetry during apneic intermittent ventilation in adult patients undergoing endolaryngeal surgery under general anesthesia. By providing continuous, noninvasive assessment of oxygen reserve in the hyperoxic range, ORi may offer an earlier warning of oxygen depletion before peripheral oxygen saturation declines. The study compares time to reventilation thresholds, arterial blood gas parameters, and perioperative respiratory outcomes between ORi-guided and standard SpO₂-guided monitoring strategies.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: * Age 18 years or older * Scheduled for elective endolaryngeal surgery * Planned general anesthesia with apneic intermittent ventilation * American Society of Anesthesiologists (ASA) physical status I-III * Ability to provide written informed consent Exclusion Criteria: * Age under 18 years * Preoperative chronic hypoxemia (baseline SpO₂ \< 95%) * Patients transferred from the intensive care unit * ASA physical status IV or higher * Refusal or inability to provide informed consent

Primary outcome measure(s)

  • Time to Reventilation Threshold — From the onset of apnea until the predefined reventilation threshold is reached during the intraoperative period (within minutes).
    Time from the onset of apnea to the predefined reventilation threshold, defined as Oxygen Reserve Index (ORi) reaching zero in the ORi group and peripheral oxygen saturation (SpO₂) decreasing to 90% in the control group, measured in seconds.

Trial sites (1)

FacilityCityRegionStatus
Istanbul University, Department of anesthesiology Istanbul Fatih

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Other trials for the same condition

The Effectiveness of Oxygen Reserve Index in Early Detection of Desaturation in Geriatric Patients Scheduled for Oncological Surgery Recruiting
Comparison of the Time to Reach End-Tidal Oxygen Value of 90 and Oxygen Reserve Index Decline Times During Preoxygenation in Sarcopenic and Non-Sarcopenic Patients Starting soon
The Role of Oxygen Reserve Index (ORi) in Apneic Ventilation Starting soon
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07415161 on ClinicalTrials.gov ↗ ← All trials in Turkey