Effect of Different Root Canal Sealers on Oxidative Stress Markers

NCT07059481 · tracked via the Priya Life Science Turkey tracker

Sponsor

bengi gülgü

Phase

Not applicable

Started

2024-03-18

Last updated

2025-07-10

Condition(s) studied

Oxidative StressChronic Apical Periodontitis

Investigational drug(s) / intervention(s)

Root Canal Treatment and Sample CollectionPAI Score Comparasion

Root Canal Treatment and Sample Collection: Single session root canal treatment procedure will be performed with VDW Gold Reciproc device and reciprocal files (Endo T-Must, Dentac, Turkey). Endodontium Samples will be collected from each patient's root canal, with 15 Hedström files (Dentsplay).

PAI Score Comparasion: PAI scores of the patients will be determined with periapical films taken before treatment and compared with oxidative stress markers before and after treatment for the epoxyamine group and bioceramic group.

Study summary

The goal of this clinical trial is to primary purpose investigate and compare oxidative stress markers in patients with chronic apical periodontitis treated with different root canal paste in a single session. The main questions it aims to answer are:

Is there a change in oxidative stress markers measured from saliva after root canal treatment? Is there a difference between the change of oxidative stress markers in patients using different root canal sealers after root canal treatment?

Researchers will compare bioceramic-based and epoxy resin-based root canal sealers to see if there are significant differences in oxidative stress markers measured from patients' saliva after root canal treatment.

* Participants will be informed about all procedures before starting the clinical process.
* Participants are expected to allow saliva sampling two times: first sample will be collected on root canal treatment session and second sample will be collected on the 30th day after root canal treatment.
* Participants will be informed in writing about the treatment procedure before starting the clinical process.
* Participants are expected to sign the informed consent form on a voluntary basis.

Eligibility

Sex

ALL

Min age

18 Years

Max age

45 Years

Healthy volunteers

Accepted

Inclusion Criteria: * Systemically healthy, ASA1 patients, * Phase 1 periodontal treatment was performed, * Diagnosed with chronic apical periodontitis in a single tooth with 2 or more roots in the mouth, * The lesion measured \<2 cm on radiographic evaluation, * The vitality of the tooth was checked by EPT (Ai-Pex, Woodpecker, China) and Cold test (Cerkamed, Poland) and confirmed to be devitalised, * Socioculturally able to participate in the treatment, * Individuals who did not smoke or drink alcohol Exclusion Criteria: * Patients who have used antibiotics in the last three months and analgesics in the last two weeks * Patients who smoke and/or abuse alcohol * Patients younger than 18 years or older than 45 years, * Patients with controlled or uncontrolled systemic disease and life-threatening conditions (ASA 2,3,4,5,6) * Pregnant or lactating women, * Patients with poor oral hygiene, * Patients who had head and neck radiotherapy, * With obesity, * Active periodontal disease, * Periodontal pocket depth over 3mm, * There is enough loss of material in the relevant tooth to prevent adequate isolation or to require post placement, * Clinical examination of the relevant tooth showing symptoms in percussion-palpation, * Radiographically, the lesion is seen in relation to anatomical formations such as the mandibular canal and maxillary sinus, * Patients who required prophylactic antibiotic use before invasive dental procedures were excluded from the study. * Patients who did not attend the follow-up appointment and patients who experienced complications during expansion (instrument seperation, perforation, etc.) were excluded from the study.

Primary outcome measure(s)

Changes in biochemically measured oxidative stress markers at 30th day in patients treated with epoxyamine/bioceramic root canal pastes. — three month aproximately
oxidative stress markers (myeloperoxidase, 8-epi, total oxidant status, total antioxidant status, oxidative stress index, malondialdehyde) will be measured and compared biochemically in saliva samples taken from the patients on the first and thirtieth day.
Comparison of the changes observed in biochemically measured oxidative stress markers of patients in the bioceramic group and patients in the epoxyamine group at day 1 and day 30 — three month aproximately
results of oxidative stress measurement obtained from bioceramic group and epoxyamin group will be compared. comparsion will be performed with biochemical kits for saliva samples.

Trial sites (1)

Facility	City	Region	Status
Ordu University	Ordu	Ordu- Altınordu	Recruiting

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The Aim of This Study is to Evaluate the Relationship Between Genetic Polymorphisms and Periapical Lesion Healing in Individuals With Chronic Apical Periodontitis at Clinical and Radiological Levels. Active, not recruiting

Effects of Irrigation Activation Methods on Periapical Healing in Chronic Apical Periodontitis Active, not recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07059481 on ClinicalTrials.gov ↗ ← All trials in Turkey