A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma
Condition(s) studied
Investigational drug(s) / intervention(s)
Daratumumab: Daratumumab will be administered SC injection.
Pomalidomide: Pomalidomide will be administered orally.
Dexamethasone: Dexamethasone will be administered orally or intravenously.
Bortezomib: Bortezomib will be administered SC injection.
Teclistamab: Teclistamab will be administered SC injection.
Study summary
The purpose of this study is to compare the efficacy of teclistamab daratumumab (Tec-Dara) with daratumumab subcutaneously (SC) in combination with pomalidomide and dexamethasone (DPd) or daratumumab SC in combination with bortezomib and dexamethasone (DVd).
Eligibility
Primary outcome measure(s)
- Progression Free Survival (PFS) — Up to 5 years
PFS is defined as the time from the date of randomization to the date of first documented disease progression, as defined in the International Myeloma Working Group (IMWG) criteria, or death due to any cause, whichever occurs first.
Trial sites (176)
| Facility | City | Region | Status |
|---|---|---|---|
| University of Alabama Birmingham | Birmingham | Alabama | |
| City of Hope | Duarte | California | |
| Stanford University Medical Center | Stanford | California | |
| Yale University | New Haven | Connecticut | |
| Emory University Winship Cancer Institute | Atlanta | Georgia | |
| Tufts Medical Center | Boston | Massachusetts | |
| Henry Ford Hospital | Detroit | Michigan | |
| Henry Ford Health System | Southfield | Michigan | |
| Cleveland Clinic | Cleveland | Ohio | |
| West Penn Hospital | Pittsburgh | Pennsylvania | |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | |
| Medical University of South Carolina | Charleston | South Carolina | |
| Baptist Cancer Center | Memphis | Tennessee | |
| Vanderbilt Ingram Cancer Center | Nashville | Tennessee | |
| University of Texas Southwestern Medical Center | Dallas | Texas | |
| Huntsman Cancer Institute | Salt Lake City | Utah | |
| Fred Hutchinson Cancer Center | Seattle | Washington | |
| University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | |
| Hospital Italiano de Buenos Aires | Buenos Aires | Argentina | |
| Hospital Aleman | CABA | Argentina | |
| Hospital Privado Centro Medico de Cordoba | Córdoba | Argentina | |
| ZAS Cadix | Antwerp | Belgium | |
| AZ St.-Jan Brugge-Oostende AV | Bruges | Belgium | |
| UZ Gent | Ghent | Belgium | |
| Hopital de Jolimont | Haine Saint Paul La Louviere | Belgium | |
| Az Groeninge | Kortrijk | Belgium | |
| UZ Leuven | Leuven | Belgium | |
| Algemeen Ziekenhuis Delta | Roeselare | Belgium | |
| Hospitais Integradaos da Gavea S/A - DF Star | Brasília | Brazil | |
| Hospital Erasto Gaertner- Liga Paranaense de Combate ao Cancer | Curitiba | Brazil | |
| Centro de Pesquisa e Ensino em Oncologia de Santa Catarina CEPEN | Florianópolis | Brazil | |
| Liga Norte Riograndense Contra O Cancer | Natal | Brazil | |
| Irmandade Santa Casa de Misericordia de Porto Alegre | Porto Alegre | Brazil | |
| Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI) | Rio de Janeiro | Brazil | |
| IDOR - Regional Bahia | Salvador | Brazil | |
| Real e Benemerita Associacao Portuguesa de Beneficencia | São Paulo | Brazil | |
| Hospital Paulistano | São Paulo | Brazil | |
| Clinica Medica Sao Germano LTDA | São Paulo | Brazil | |
| Instituto D Or de Pesquisa e Ensino IDOR | São Paulo | Brazil | |
| Arthur J E Child Comprehensive Cancer Centre | Calgary | Alberta |
+ 136 more sites — see the full list on the official registry below.
On this site
📄 Darzalex (daratumumab) drug profile →More Janssen Research & Development, LLC trials in Turkey
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05083169 on ClinicalTrials.gov ↗ ← All trials in Turkey