Clinical Trials in Taiwan / NCT07186023
Recruiting
Not applicable
Effects of Mindfulness or Brain Stimulation Intervention for Late-life Adults in Taiwan Urban and Rural Areas
NCT07186023 · tracked via the Priya Life Science Taiwan tracker
Condition(s) studied
Late-Life AdultsLate-Life Prodromal DepressionLate-Life DepressionMindfulnessBrain Stimulation Intervention
Investigational drug(s) / intervention(s)
MBSRMBWCMBCIBSI
MBSR: Mindfulness-Based Stress Reduction
MBWC: Mindfulness-Based Well-Being Curriculum
MBCI: Mindfulness-Based Curriculum for Insomnia
BSI: Brain Stimulation Intervention
Study summary
This randomized controlled trial will examine the effects of mindfulness-based interventions and brain stimulation interventions on cognitive function and psychological well-being in older adults. The study will employ a comprehensive assessment approach incorporating psychological evaluations, behavioral assessments, psychophysiological measurements, and neuroimaging analyses to characterize the outcome of nonpharmaceutical interventions in improving geriatric well-being or reducing depression severity.
Eligibility
Inclusion Criteria for individuals participating in mindfulness-based Interventions:
* Literate or have received an education above the elementary level.
* Have normal or corrected vision and hearing, able to communicate and understand explanations.
* Right-handed individuals as assessed by the Edinburgh Handedness Inventory.
Exclusion Criteria for individuals participating in mindfulness-based Interventions:
* Individuals with dementia, stroke, cerebrovascular disease, brain injury, epilepsy, or Parkinson's disease.
* Individuals with neurological system disorders.
* Individuals with alcohol or drug dependence.
* Individuals with other major physical illnesses, such as diabetes, heart failure, or endocrine abnormalities, or those who have experienced an acute myocardial infarction within the past three months.
* Individuals with metal objects in the body that cannot undergo magnetic resonance imaging (MRI), such as cardiac pacemakers, vascular clips, hearing aids, artificial joints, steel pins, etc.
* Individuals with Claustrophobia.
* Individuals in pregnancy or possibility of pregnancy.
Inclusion Criteria for individuals participating in brain stimulation Intervention:
* Individuals diagnosed with major depressive disorder by psychiatrists according to the Diagnostic and Statistical Manual, and who can cooperate with the psychiatric outpatient clinic regulations.
* Literate or have received an education above the elementary level.
* Have normal or corrected vision and hearing, able to communicate and understand explanations.
* Right-handed individuals as assessed by the Edinburgh Handedness Inventory.
* Individuals are prescribed brain stimulation therapy by clinical physicians.
Exclusion Criteria for individuals participating in brain stimulation Intervention:
* Individuals with dementia, stroke, cerebrovascular disease, brain injury, epilepsy, or Parkinson's disease.
* Individuals with neurological system disorders.
* Individuals with alcohol or drug dependence.
* Individuals with other major physical illnesses, such as diabetes, heart failure, or endocrine abnormalities, or those who have experienced an acute myocardial infarction within the past three months.
* Individuals with metal objects in the body that cannot undergo magnetic resonance imaging (MRI), such as cardiac pacemakers, vascular clips, hearing aids, artificial joints, steel pins, etc.
* Individuals with Claustrophobia.
* Individuals in pregnancy or possibility of pregnancy.
Primary outcome measure(s)
- Changes in neural activation related to emotional processing, sensory processing, attention, and memory-related brain regions. — Baseline assessment conducted during the 4-week period prior to intervention initiation; follow-up assessment conducted during the 4-week period following intervention completion.
Significant alterations in blood oxygen level-dependent (BOLD) signal amplitude during task-based functional magnetic resonance imaging (fMRI). - Changes in resting-state functional connectivity within and between brain networks — Baseline assessment conducted during the 4-week period prior to intervention initiation; follow-up assessment conducted during the 4-week period following intervention completion.
Statistically significant alterations in intrinsic functional connectivity parameters derived from blood-oxygen-level-dependent (BOLD) signals acquired during resting-state functional magnetic resonance imaging (rs-fMRI).
Trial sites (2)
| Facility | City | Region | Status |
|---|---|---|---|
| Shuang Ho Biomedical Park, Taipei Medical University | New Taipei City | Taiwan | Recruiting |
| National Center for Geriatrics and Welfare Research | Yunlin | Taiwan | Not Yet Recruiting |
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Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07186023 on ClinicalTrials.gov ↗ ← All trials in Taiwan