This project will clarify the potential interaction between HBV infection and steatosis, and their impact on genetic alterations and tumor immune microenvironment.
Eligibility
Sex
ALL
Min age
20 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
1. Adult female or male patients aged ≥20 years.
2. HCC has been histologically confirmed with resection specimen.
3. The surgery should be performed with curative intent after 2015 in the study hospital.
4. Availability of serum HBsAg and Anti-HBc data in the electronic medical record.
5. Availability of imaging data performed within 3 months before the surgery in the electronic medical record. (at least one of the following: computed tomography, magnetic resonance imaging, abdominal sonography).
6. Informed consent is obtained. Willingness to provide the residual operative slides and medical records.
Exclusion Criteria:
1. Fibrolamellar HCC, sarcomatoid HCC, or a mixture of cholangiocarcinoma and HCC
2. Exclusion of HCV patients (Anti-HCV positive)
3. Inability to cooperate by providing a complete medical history.
Primary outcome measure(s)
transcriptomic analysis of immune microenvironment — 2 Years using RNA-seq and multiplex immunofluorescence staining
lipotoxic genotyping for SNPs — 2 years lipotoxic genotyping for SNPs
clinical outcomes of MAFLD vs. non-MAFLD. — 2 years clinical outcomes of MAFLD vs. non-MAFLD.
Trial sites (4)
Facility
City
Region
Status
National Cheng-Kung University Hospital
Tainan
Taiwan
National Taiwan University Hospital
Taipei
Taiwan
Mackay Memorial Hospital
Taipei
Taiwan
National Taiwan University Cancer Center
Taipei
Taiwan
More National Health Research Institutes, Taiwan trials in Taiwan
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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