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Clinical Trials in Switzerland / NCT06958848
Recruiting Not applicable

16F vs 24F Chest Drain After Minimally Invasive Lobectomy and/or Segmentectomy

NCT06958848 · tracked via the Priya Life Science Switzerland tracker
Sponsor
University Hospital, Basel, Switzerland
Phase
Not applicable
Started
2025-05-01
Last updated
2026-05-06

Condition(s) studied

PneumothoraxPleural Effusion

Investigational drug(s) / intervention(s)

16 F chest tube24 F chest tubeEarly removalStandard removal

16 F chest tube: Insertion of 16F chest tube

24 F chest tube: Insertion of 24F chest tube

Early removal: Removal 2-6h after end of skin closure

Standard removal: Removal 1day postoperative

Study summary

The aim of the study is to evaluate postoperative pain in patients receiving a small-bore (16F) chest drain compared to those receiving the standard large-bore (24F) chest drain after minimally invasive pulmonary lobectomy and/or segmentectomy.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Informed Consent signed by the patient (all sex and gender) * Patients' age from ≥ 18 to no age limit at time of study inclusion * American Society of Anaesthesiologists (ASA) physical status classification I to IV * Patients with resectable non-small cell lung cancer (NSCLC) deemed operable by minimally invasive surgical technique. * Minimally invasive anatomical lung resections under general anaesthesia: lobectomy, lobectomy with wedge resection, lobectomy combined with segmentectomy, segmentectomy with wedge resection, bilobectomy Exclusion Criteria: * Previous thoracic surgery on the same side within 3 months * Lung cancer complicated with pleural empyema * Patients with chronic pain who receive opioids/gabapentin/pregabalin * Patients who consume opiates/benzodiazepines * Congestive heart failure NYHA Class III or IV * Liver cirrhosis Child-Pugh Class B and C * Renal insufficiency requiring dialysis and/or estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73 m2 * Patients with coagulopathy or bleeding disorders: von Willebrand disease, Hemophilia; Thrombocytopenia (\<50 G/l), requiring platelet transfusion * Patients with neuralgia * Chest pain (site of surgery) without taking painkillers, measured by VAS while coughing \> 10 mm * Not consolidated rib fractures (in the last 3 months) on the side of surgical procedure * Open anatomical lung resection, including pneumonectomy * Insertion of 2 or more chest tubes * Need for patient controlled intravenous anaesthesia or patient controlled epidural anaesthesia * Patients intubated/sedated (not suitable due to difficulties to fill out the pain survey)

Primary outcome measure(s)

  • Postoperative chest pain — 4 and 6 hours after last suture; twice daily from day 1 to day 3 postoperative or until tube removal; on discharge home; on follow up day 30 and 180.
    Postoperative pain related to the placed chest drain (16F versus 24F), measured on a visual analogue scale (VAS) while coughing at different time points from skin closure until standard chest drain removal. The VAS is a horizontal line (100 mm) labelled from "no pain" on the left (0 mm) to "most extreme pain experienced" on the right (100 mm). Chest pain intensity is measured and recorded at rest and while coughing. For the current pain rating, the patient must be shown their last rating for comparison. The patient marks their information with a vertical line on the horizontal score line of the sheet paper. If needed, assistance with filling out the form will be provided. The evaluation is carried out by measuring the distance from the low anchor point to the marking; the recorded values are expressed in millimetres (0-100).
  • Postoperative acute pain relief while coughing — 4 and 6 hours after last suture; twice daily from day 1 to day 3 postoperative or until tube removal; on discharge home; on follow up day 30 and 180.
    Postoperative acute pain relief while coughing in the other 5 pairwise comparisons. Pain is measured on a visual analogue scale (VAS) while coughing. The VAS is a horizontal line (100 mm) labelled from "no pain" on the left (0 mm) to "most extreme pain experienced" on the right (100 mm).

Trial sites (1)

FacilityCityRegionStatus
University Hospital Basel Basel Switzerland Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06958848 on ClinicalTrials.gov ↗ ← All trials in Switzerland