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Clinical Trials in Switzerland / NCT06340178
Recruiting Not applicable

CT-guided Lung Biopsy Risk Optimization Method

NCT06340178 · tracked via the Priya Life Science Switzerland tracker
Sponsor
Insel Gruppe AG, University Hospital Bern
Phase
Not applicable
Started
2025-09-29
Last updated
2026-02-02

Condition(s) studied

PneumothoraxBiopsy, NeedleRisk FactorsRadiology, Interventional

Investigational drug(s) / intervention(s)

Fluid application during ct-guided lung biopsy

Fluid application during ct-guided lung biopsy: Injection of a small amount of fluid (max. 20 ml sodium chlorid) in the pleural cavity at the biopsy site

Study summary

The purpose of this randomized controlled study is to evaluate the extent to which injection of a small amount of fluid in the pleural cavity at the biopsy site may reduce the risk of pneumothoraces, in addition to patient positioning to allow biopsy in gravity-dependent areas of the lung.

Eligibility

Sex
ALL
Min age
18 Years
Max age
100 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Ability to provide informed consent (knowledge of project languages), \>18 years. * Indeterminate or suspicious lung lesion unsuitable for transbronchial biopsy or Status after unsuccessful transbronchial biopsy * Indication for biopsy given by referring specialist (in patients). Exclusion Criteria: * Preintervention bleeding into the pleural cavity * More than 1 lesion should be biopsied at the same time * Infiltration of the thoracic wall * Pregnancy

Primary outcome measure(s)

  • Number of patients with pneumothorax — Immediate after biopsy, expected to be on average 5 minutes
    Reduction of pneumothorax occurrence in patients with biopsy in dependent lung areas and pleural fluid administration compared to patients with biopsy in dependent lung areas without fluid administration. Immediately after the lung biopsy, the final CT scan of the intervention is used to check whether a pneumothorax is present or not - i.e. whether there is new air in the pleural cavity.

Trial sites (1)

FacilityCityRegionStatus
Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10 Bern Switzerland Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06340178 on ClinicalTrials.gov ↗ ← All trials in Switzerland