The Inselspital Surgical Cohort Study

Condition(s) studied

Investigational drug(s) / intervention(s)

Blood and urine samples, skin and stool swabs: Blood samples will be collected before surgery, on the first postoperative day and after 3-8 weeks. Urine samples will be collected after surgery and after 3-8 weeks. Stool and skin swabs will be collected before surgery.

Study summary

Personalizing surgical care is of enormous clinical relevance, when considering the number of patients undergoing surgery in Switzerland every year. Currently, personalization is based on underlying or coexisting disease or alterations of laboratory values, but there is no accepted biological test available that may predict success or failure of surgery. Surgical site infections are the most common form of hospital-acquired infections. While the relevance of bacteria, antibiotics and intensive care support is well accepted, the impact of the individual host response remains poorly understood. The Investigators hypothesize that postoperative alterations of the metabolome allow identification of predictors of surgical complications in general, and surgical site infections in particular.

Eligibility

Primary outcome measure(s)

• Incidence of surgical site infection — 30 days
  Number of patients with surgical site infections 30 days postoperatively

Trial sites (1)

More Insel Gruppe AG, University Hospital Bern trials in Switzerland

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