Cardiovascular Autonomic Function After Resistance Training

NCT07725952 · tracked via the Priya Life Science South Korea tracker

Sponsor

Pusan National University Yangsan Hospital

Phase

Not applicable

Started

2026-10-01

Last updated

2026-09-03

Condition(s) studied

Spinal Cord Injury

Investigational drug(s) / intervention(s)

Upper-Limb Resistance Training

Upper-Limb Resistance Training: Participants will perform a supervised upper-limb resistance training program three times per week for 8 weeks. Each session will last approximately 30 minutes and consist of progressive resistance exercises for the upper extremities. Exercise intensity will be progressively adjusted according to each participant's tolerance.

Study summary

The purpose of this clinical trial is to evaluate whether an 8-week upper-limb resistance training program improves cardiovascular autonomic function in adults with chronic spinal cord injury (SCI). The primary objectives are to determine whether upper-limb resistance training improves heart rate variability (HRV) and baroreflex sensitivity (BRS), and whether it improves blood pressure responses during postural change, upper-limb strength, symptoms related to orthostatic hypotension, and quality of life.

Participants will be randomly assigned to either the resistance training group or the control group. All participants will complete assessments before and after the 8-week study period, including measurements of HRV, BRS, blood pressure responses during a tilt-table test, hand grip strength, and questionnaires assessing orthostatic hypotension symptoms and quality of life. Participants assigned to the resistance training group will participate in supervised upper-limb resistance training three times per week for 8 weeks.

Eligibility

Sex

ALL

Min age

19 Years

Max age

85 Years

Healthy volunteers

Inclusion Criteria: * Provided written informed consent and agreed to participate in the study. * Adults aged 19 to 85 years. * Chronic spinal cord injury (SCI) of traumatic or non-traumatic etiology, at least 6 months after injury. * Cervical or thoracic spinal cord injury. * Classified as American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade A, B, C, or D. * Sufficient upper-limb range of motion to perform resistance training. * Elbow extensor muscle strength of Manual Muscle Test (MMT) grade 3 or higher. Exclusion Criteria: * Presence of any serious medical condition that would preclude participation in the study. * Inability to understand or perform the exercise program. * Uncontrolled diabetes mellitus or progressive neurological disease. * Uncontrolled hypertension (systolic blood pressure \>140 mmHg or diastolic blood pressure \>90 mmHg). * History of cardiovascular disease within the past 6 months. * Current use of medications that may affect heart rate variability (HRV) or baroreflex sensitivity (BRS). * Severe orthostatic hypotension (OH) or autonomic dysreflexia (AD). * Considered unsuitable for participation in the study by a board-certified specialist in Physical and Rehabilitation Medicine.

Primary outcome measure(s)

Heart Rate Variability — Baseline and Week 8
Heart rate variability will be assessed to evaluate changes in cardiovascular autonomic function following the 8-week intervention.
Baroreflex Sensitivity — Baseline and Week 8
Baroreflex sensitivity will be assessed to evaluate changes in cardiovascular autonomic function following the 8-week intervention.

Trial sites (1)

Facility	City	Region	Status
Pusan National University Yangsan Hospital	Yangsan	Gyeongsangnam-do

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07725952 on ClinicalTrials.gov ↗ ← All trials in South Korea