Comparison of Sevoflurane and Desflurane on ANI in Patients Undergoing General Anesthesia: a Prospective Randomized Controlled Study

NCT07511634 · tracked via the Priya Life Science South Korea tracker

Sponsor

Pusan National University Yangsan Hospital

Phase

Not applicable

Started

2026-04-01

Last updated

2026-04-06

Condition(s) studied

General Anesthesia

Investigational drug(s) / intervention(s)

Desflurane →Sevoflurane →

Desflurane: Desflurane will be administered for maintenance of general anesthesia after loss of consciousness following propofol induction. End-tidal desflurane concentration will be titrated to age-adjusted 1.0 MAC (±0.1 MAC) at the time of ANI assessment.

Sevoflurane: Sevoflurane will be administered for maintenance of general anesthesia after loss of consciousness following propofol induction. End-tidal sevoflurane concentration will be titrated to age-adjusted 1.0 MAC (±0.1 MAC) at the time of ANI assessment.

Study summary

This prospective randomized controlled study will compare the effects of sevoflurane and desflurane on the Analgesia Nociception Index (ANI) in adult patients undergoing general anesthesia. Participants will be randomized to maintenance anesthesia with either sevoflurane or desflurane, and ANI responses to a standardized nociceptive stimulus will be measured under equi-minimum alveolar concentration (age-adjusted 1.0 MAC) conditions. The primary objective is to compare the change in ANI before and after tetanic stimulation between the two anesthetic groups. Secondary measurements will include bispectral index, blood pressure, heart rate, and end-tidal anesthetic concentration around the time of stimulation.

Eligibility

Sex

ALL

Min age

19 Years

Max age

79 Years

Healthy volunteers

Inclusion Criteria: * Adults aged 19 to 79 years * Patients undergoing general anesthesia * American Society of Anesthesiologists (ASA) physical status I or II Exclusion Criteria: * History of taking medications that may affect the central nervous system or autonomic nervous system (e.g., anticholinergics, beta-blockers, antidepressants, anxiolytics, hypnotics, or analgesics) * Known hypersensitivity to sevoflurane, desflurane, or other halogenated anesthetics, or a personal or family history of malignant hyperthermia * Neurologic or psychiatric disorders (e.g., depression, dementia, or cerebral infarction) * Arrhythmia * Diabetes mellitus * Drug abuse or alcohol abuse * Vulnerable subjects * Patients aged 80 years or older * Patients with impaired consciousness or those judged to lack the capacity to provide informed consent

Primary outcome measure(s)

Change in Analgesia Nociception Index (ANI) From 1 Minute Before to 1 Minute After Tetanic Stimulation — From 1 minute before tetanic stimulation to 1 minute after tetanic stimulation
ANI will be measured 1 minute before and 1 minute after standardized tetanic stimulation. The primary analysis will compare the between-group difference in ANI change from before to after stimulation.

Trial sites (1)

Facility	City	Region	Status
Pusan National University Yangsan Hospital	Yangsan	Gyeongsangnam-do

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07511634 on ClinicalTrials.gov ↗ ← All trials in South Korea