A Research Study to See How NNC0487-0111 Affects the Body's Energy Use After a Weight Loss in Adults Living With Overweight or Obesity, Compared to a Low-calorie Diet or Placebo
Condition(s) studied
Investigational drug(s) / intervention(s)
NNC0487-0111: NNC0487-0111 will be administered subcutaneously.
Placebo: Placebo matched to NNC0487-0111 will be administered subcutaneously.
LED: A meal plan and meal replacements will be provided by the investigators.
Study summary
The purpose of this clinical study is to evaluate how NNC0487-0111 affects the amount of energy the body uses in people living with obesity or overweight following weight loss. This will be compared with the amount of energy used by participants who achieve weight loss through a low-calorie diet and by participants receiving placebo (without weight loss).
Eligibility
Primary outcome measure(s)
- Change in sleeping metabolic rate (SMR) — Baseline (week 0) to week 12-26
Measured in kilojoules per day (kJ/day)
Trial sites (2)
| Facility | City | Region | Status |
|---|---|---|---|
| Aarhus Universitetshospital, Steno Diabetes Center Aarhus | Aarhus N | Denmark | Recruiting |
| Maastricht University-NUTRIM-Dep Human Biology-Obesity | Maastricht | Netherlands | Recruiting |
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Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07757087 on ClinicalTrials.gov ↗ ← All trials in the Netherlands