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Clinical Trials in the Netherlands / NCT06841003
Recruiting Phase 3

Laparoscopic Antibiotic Lavage to Prevent Intra-abdominal Abscess Formation in Complicated Appendicitis

NCT06841003 · tracked via the Priya Life Science Netherlands tracker
Sponsor
Spaarne Gasthuis
Phase
Phase 3
Started
2025-02-24
Last updated
2026-10-09

Condition(s) studied

Complicated AppendicitisIntra-Abdominal Abscess

Investigational drug(s) / intervention(s)

Laparoscopic antibiotic peritoneal lavage with gentamicin / clindamycin

Laparoscopic antibiotic peritoneal lavage with gentamicin / clindamycin: Peritoneal antibiotic lavage using a solution of gentamicin/clindamycin in NaCl 0.9%.

Study summary

Appendicitis is one of the most common causes of acute surgical admission. Presently, two types of appendicitis are distinguished: complicated and uncomplicated (phlegmonous). Complicated appendicitis (CA) is defined as gangrenous and/or perforated appendicitis and/or appendicitis with an intra-abdominal or pelvic abscess. Laparoscopic appendectomy has become the preferential mode of surgical treatment. However, development of an intra-abdominal abscess (IAA) remains an important and clinically relevant complication following appendectomy, especially in complicated appendicitis. Although patients with complicated appendicitis receive postoperative intravenous antibiotics, the incidence of IAA remains considerable. The reported incidence of IAA in children and adults with CA is 7.9% - 24%. We recently reported an IAA rate of 12.3% after laparoscopic appendectomy for CA in our own institution. Patients with IAA are readmitted and treated with either antibiotics, image-guided percutaneous drainage, surgical reintervention, or a combination of these treatments. Furthermore, IAA represents a considerable burden for the healthcare system with high readmission rates and reinterventions, prolonged hospital stay, and therefore increased medical costs. Intra operative techniques aiming at more effective infection source control represent a clinically relevant area of investigation. Laparoscopic antibiotic lavage represents a promising concept in order to reduce intra-abdominal abscess formation. Antibiotic lavage is mainly known for the treatment of peritoneal dialysis associated peritonitis. Several studies show promising results of antibiotic peritoneal lavage on the incidence of surgical site infections (SSIs) including IAA in patients with CA. However, these studies were retrospective or conducted in a small number of patients who underwent an open appendectomy while high quality randomized controlled trials have not been performed yet.

The aim of the ALPACA study is to evaluate the effect of laparoscopic antibiotic peritoneal lavage with gentamicin / clindamycin for 3 minutes after appendectomy on the incidence of IAA in patients with CA.

Eligibility

Sex
ALL
Min age
8 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * All patients ≥ 8 years with a preoperative diagnosis of acute appendicitis either with or without clinical or radiological suspicion of CA undergoing a laparoscopic appendectomy for intra-operative confirmed CA that can provide a signed written consent form. Exclusion Criteria: * Age under 8 years; * Not able to give informed consent (language barrier, legally incapable) * Any contraindication for the use of the study medication: * Hypersensitivity to clindamycin or to any of the excipients benzyl alcohol, sodium edetate, water, or to lincomycin; * Hypersensitivity to gentamicin or to sodium metabisulfite: particularly in asthmatic patients, this may trigger bronchospasms and anaphylactic shock or to any of the excipients: disodium edetate, sodium hydroxide, sodium metabisulfite (E223), water for injections; * Severe sepsis defined as sepsis-induced tissue hypoperfusion or organ dysfunction that includes any of the following thought to be caused by the infection: * Sepsis-induced hypotension * Lactate above upper limits laboratory normal * Urine output \<0.5 mL/kg/h for more than 2h despite adequate fluid resuscitation * Acute lung injury with PaO2/FiO2 \<250 in the absence of pneumonia as infection source * Acute lung injury with PaO2/FiO2 \<200 in the presence of pneumonia as infection source * Creatinine \>2.0 mg/dL (176.8 μmol/L) * Bilirubin \>2mg/dL (34.2 μmol/L) * Platelet count \< 100,000 μL * Coagulopathy (international normalized ratio (INR) \> 1.5); * ASA IV score; * Known malignancy; * Renal dysfunction (i.e. eGFR ≤ 60); * Immunocompromised patients (i.e. hematological malignancies, HIV/AIDS, bone marrow transplantation, splenectomy, genetic disorders such as severe combined immunodeficiency, chemotherapy, dialysis, solid organ transplant, and immunosuppressant use (such as corticosteroids in patients with rheumatoid arthritis)); * Pregnancy; * Known allergies to either gentamicin or clindamycin; * Known colonization of bacteria resistant to either gentamicin or clindamycin;

Primary outcome measure(s)

  • The incidence of intra-abdominal abscess (IAA) — Within 30 days follow-up

Trial sites (11)

FacilityCityRegionStatus
Zuyderland Medisch Centrum Heerlen Limburg Not Yet Recruiting
Máxima MC Veldhoven North Brabant Recruiting
Noordwest Ziekenhuisgroep Alkmaar North Holland Recruiting
Rode Kruis Ziekenhuis Beverwijk North Holland Recruiting
Spaarne Gasthuis Hoofddorp North Holland Recruiting
Dijklander Ziekenhuis Hoorn North Holland Recruiting
Zaans Medisch Centrum Zaandam North Holland Recruiting
Ziekenhuisgroep Twente Almelo Overijssel Recruiting
Isala Zwolle Overijssel Recruiting
Ijsselland Ziekenhuis Capelle aan den IJssel South Holland Recruiting
Meander Medisch Centrum Amersfoort Utrecht Recruiting

More Spaarne Gasthuis trials in the Netherlands

Poly vs Hybrid Glenoid in Stemless aTSA Recruiting
The ATtune Knee Outcome Study Recruiting
ALknee Follow-up Study of the Cementless ATTUNE Rotating Platform and the Cementless LCS Rotating Platform Knee System Active, not recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06841003 on ClinicalTrials.gov ↗ ← All trials in the Netherlands