Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
Condition(s) studied
Investigational drug(s) / intervention(s)
INCB123667: Oral; tablet
Investigator's choice of chemotherapy: The investigator will select the chemotherapy in accordance with the protocol-defined requirements. The possible choices as defined by the protocol:
Study summary
The purpose of this study is to evaluate INCB123667 versus investigator's choice of chemotherapy in participants with platinum-resistant ovarian cancer with cyclin E1 overexpression.
Eligibility
Primary outcome measure(s)
- Progression-Free Survival (PFS) by BICR — Up to 2 years
Defined as the time from the date of randomization until the earliest date of disease progression as determined by blinded independent central review (BICR) per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1, or death due to any cause, whichever occurs first. - Overall Survival (OS) — Up to 2 years
Defined as the time from the date of randomization until death due to any cause.
Trial sites (198)
| Facility | City | Region | Status |
|---|---|---|---|
| Alaska Womens Cancer Care Akwcc | Anchorage | Alaska | Completed |
| University of Arizona Cancer Center | Tucson | Arizona | Completed |
| City of Hope Medical Center | Duarte | California | Recruiting |
| Providence Medical Foundation | Fullerton | California | Completed |
| University of California, San Diego-Moores Cancer Center | La Jolla | California | Completed |
| Valkyrie Clinical Trials | Los Angeles | California | Recruiting |
| Uci Health Chao Family Comprehensive Cancer Center | Orange | California | Completed |
| Ventura County Hematology Oncology Specialists-Oxnard | Oxnard | California | Completed |
| University of Colorado Cancer Center | Aurora | Colorado | Completed |
| Mount Sinai Medical Center Comprehensive Cancer Center | Miami Beach | Florida | Not Yet Recruiting |
| Brcr Global | Miramar | Florida | Completed |
| Sarasota Memorial Health Care System | Sarasota | Florida | Completed |
| Winship Cancer Institute At Emory University | Atlanta | Georgia | Completed |
| Georgia Cancer Center | Augusta | Georgia | Completed |
| The University of Chicago Medicine | Chicago | Illinois | Completed |
| Carle Cancer Center | Effingham | Illinois | Completed |
| Northshore University Health System-Evanston Hospital | Evanston | Illinois | Completed |
| City of Hope - Chicago Cancer Center | Zion | Illinois | Completed |
| St Elizabeth Healthcare | Edgewood | Kentucky | Completed |
| Women'S Cancer Care | Covington | Louisiana | Not Yet Recruiting |
| Trials365, Llc | Shreveport | Louisiana | Not Yet Recruiting |
| Maine Center For Cancer Medicine | Scarborough | Maine | Completed |
| Holy Cross Hospital | Silver Spring | Maryland | Completed |
| Greater Baltimore Medical Center | Towson | Maryland | Not Yet Recruiting |
| Henry Ford Cancer - Detroit | Detroit | Michigan | Completed |
| Mercy Hospital St. Louis - David C. Pratt Cancer Center | St Louis | Missouri | Completed |
| Billings Clinic | Billings | Montana | Recruiting |
| Women'S Cancer Center of Nevada | Las Vegas | Nevada | Completed |
| Center of Hope | Reno | Nevada | Completed |
| Maimonides Medical Center | Short Hills | New Jersey | Not Yet Recruiting |
| Unm Comprehensive Cancer Center | Albuquerque | New Mexico | Completed |
| Levine Cancer Center | Charlotte | North Carolina | Not Yet Recruiting |
| Novant Presbyterian Hospital | Charlotte | North Carolina | Recruiting |
| East Carolina University | Greenville | North Carolina | Completed |
| Novant Health Oncology Specialists | Winston-Salem | North Carolina | Recruiting |
| Atrium Health Wake Forest Baptist | Winston-Salem | North Carolina | Not Yet Recruiting |
| Cleveland Clinic Foundation | Cleveland | Ohio | Completed |
| Ohio Health Research Institute | Columbus | Ohio | Completed |
| Miami Valley Hospital South | Dayton | Ohio | Completed |
| Promedica Flower Hospital | Sylvania | Ohio | Completed |
+ 158 more sites — see the full list on the official registry below.
More Incyte Corporation trials in Japan
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07214779 on ClinicalTrials.gov ↗ ← All trials in Japan