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Incyte Corporation clinical trials

Also registered as Incyte Corp
Source: ClinicalTrials.gov, U.S. National Library of Medicine and the EU Clinical Trials Information System (CTIS) — current trials in our USA, UK, China, Ireland and EU (CTIS) registers with Incyte Corporation as lead sponsor. Synced 26 Sep 2026
59Current trials
28Recruiting now
41Drugs in these trials
5Trial registers
Maintained by Sreepriya Prasannan
MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany HSE Spark Ignite 2026 — Top 14 finalist
Compiled from ClinicalTrials.gov and CTIS registry records · Last verified · Editorial standards
At a glance

Incyte Corporation is the lead sponsor of 59 current clinical trials in our USA, UK, China, Ireland and EU (CTIS) registers. 28 are recruiting patients now. The most common phase is Phase 3. The drugs named most often in its trials are Ruxolitinib, Povorcitinib and Axatilimab. The most-studied condition is Solid Tumors.

ClinicalTrials.gov trials by status

  • Recruiting2853%
  • Active, closed2547%

Trials by phase

  • Phase 32140%
  • Phase 11630%
  • Phase 21019%
  • Phase 1/236%
  • Observational36%
01

Clinical trials sponsored by Incyte Corporation

53 on ClinicalTrials.gov
StudyPhaseStatusStartRegisters
A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia
NCT07623200 · Essential Thrombocythemia
Phase 3 Recruiting 2026-09 UK, USA
A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease
NCT06585774 · ClinicalTrials.gov ↗ · Chronic Graft-versus-host-disease
Phase 3 Recruiting 2025-01 Ireland, UK, USA
A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)
NCT07124078 · Chronic Graft-versus-host-disease
Phase 2 Recruiting 2026-05 UK, USA
A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors
NCT05836324 · Solid Tumors, Advanced Solid Tumors, Metastatic Solid Tumors
Phase 1 Recruiting 2023-07 UK, USA, China
Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
NCT07214779 · ClinicalTrials.gov ↗ · Ovarian Cancer
Phase 3 Recruiting 2025-12 Ireland, UK, USA
Pharmacokinetics, Safety, and Efficacy of Povorcitinib in Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa
NCT07213973 · Hidradenitis Suppurativa (HS)
Phase 2 Recruiting 2026-02 USA
A Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Children (6 to < 12 Years Old) With Nonsegmental Vitiligo
NCT06804811 · ClinicalTrials.gov ↗ · NonSegmental Vitiligo
Phase 3 Recruiting 2025-11 UK
Study to Assess the Safety and Tolerability of Tafasitamab in Adult Participants With Primary Autoimmune Blood Cell Disorders
NCT07104565 · ClinicalTrials.gov ↗ · Immune Thrombocytopenia
Phase 2 Recruiting 2025-12 UK, USA
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
NCT07522073 · ClinicalTrials.gov ↗ · Solid Tumors
Phase 3 Recruiting 2026-04 UK, USA
Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib
NCT06855498 · ClinicalTrials.gov ↗ · Hidradenitis Suppurativa (HS)
Phase 3 Recruiting 2025-02 UK, USA
Observational Study for Patients at Risk for Chronic Graft-Versus-Host Disease
NCT05919511 · cGVHD
Observational Recruiting 2023-08 USA
A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
NCT07023627 · ClinicalTrials.gov ↗ · Ovarian Cancer
Phase 2 Recruiting 2025-11 UK, USA
To Assess the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva
NCT05090891 · ClinicalTrials.gov ↗ · Fibrodysplasia Ossificans Progressiva (FOP)
Phase 2 Recruiting 2022-05 UK, USA, China
Study of INCA036978 in Participants With Myeloproliferative Neoplasms
NCT07441694 · ClinicalTrials.gov ↗ · Myeloproliferative Neoplasms
Phase 1 Recruiting 2026-05 UK, USA
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
NCT07284849 · ClinicalTrials.gov ↗ · CRC (Colorectal Cancer)
Phase 3 Recruiting 2026-03 UK, USA, China
A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms
NCT06034002 · ClinicalTrials.gov ↗ · Myeloproliferative Neoplasms
Phase 1 Recruiting 2023-12 USA
An Observational Retrospective Cohort Study Being Conducted in Women With Atopic Dermatitis Exposed to Ruxolitinib Cream Versus Topical Corticosteroids During Pregnancy: A US Claims Database Analysis
NCT06627335 · ClinicalTrials.gov ↗ · Pregnancy Related, Atopic Dermatitis
Observational Recruiting 2023-03 USA
A Study to Assess the Safety and Pharmacokinetics of INCB123667 When Administered Orally to Adult Participants With Severe Renal Impairment or End Stage Renal Disease
NCT07559396 · ClinicalTrials.gov ↗ · Renal Impairment
Phase 1 Recruiting 2026-05 USA
A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203)
NCT06615050 · ClinicalTrials.gov ↗ · Graft-versus-host Disease (GVHD)
Phase 3 Recruiting 2025-04 USA
A Study to Evaluate INCA036873 in Participants With Advanced Solid Tumors and Hematological Malignancies
NCT07195916 · ClinicalTrials.gov ↗ · Solid Tumors, Hematologic Malignancies
Phase 1 Recruiting 2026-01 USA
A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo
NCT06548360 · ClinicalTrials.gov ↗ · NonSegmental Vitiligo
Phase 3 Recruiting 2025-01 USA
A Study to Assess the Safety and Pharmacokinetics of INCB123667 When Administered Orally to Adult Participants With Moderate or Severe Hepatic Impairment
NCT07559474 · ClinicalTrials.gov ↗ · Hepatic Insufficiency, Liver Diseases
Phase 1 Recruiting 2026-05 USA
A Study to Evaluate Dermal Open-Flow Microperfusion and Plasma Pharmacokinetic Study of Multiple Doses of Oral Povorcitinib or Topical Ruxolitinib Cream in Healthy Adult Participants
NCT07588139 · ClinicalTrials.gov ↗ · Healthy Participants
Phase 1 Recruiting 2026-05 USA
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
NCT06179160 · ClinicalTrials.gov ↗ · Solid Tumors
Phase 1 Recruiting 2024-01 USA
Study to Compare Maternal, Fetal, and Infant Outcomes of Women With Mild to Moderate Atopic Dermatitis Exposed to Ruxolitinib Cream During Pregnancy With an Unexposed Control Population
NCT06259669 · ClinicalTrials.gov ↗ · Pregnancy Related, Atopic Dermatitis
Observational Recruiting 2023-09 USA
A Study to Evaluate INCA035784 in Participants With Myeloproliferative Neoplasms
NCT07008118 · ClinicalTrials.gov ↗ · Myeloproliferative Neoplasms
Phase 1 Recruiting 2025-10 USA
A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of INCA033989 Following Subcutaneous or Intravenous Administration in Healthy Adult Participants
NCT07448155 · ClinicalTrials.gov ↗ · Healthy Participants
Phase 1 Recruiting 2026-03 USA
Study to Evaluate the Maximal Use of Ruxolitinib Cream in Adult and Adolescent Participants With Hidradenitis Suppurativa
NCT07049575 · ClinicalTrials.gov ↗ · Hidradenitis Suppurativa
Phase 1 Recruiting 2025-11 USA
Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS2)
NCT06958211 · Hidradenitis Suppurativa
Phase 3 Active, closed 2025-06 USA
A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma.
NCT04680052 · Follicular Lymphoma, Marginal Zone Lymphoma
Phase 3 Active, closed 2021-04 Ireland, UK, USA, China
Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients
NCT04824092 · ClinicalTrials.gov ↗ · Diffuse Large B-cell Lymphoma
Phase 3 Active, closed 2021-05 Ireland, UK, USA
A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa
NCT06212999 · Hidradenitis Suppurativa (HS)
Phase 3 Active, closed 2024-01 UK, USA
Study to Evaluate the Safety and Efficacy of Tafasitamab Plus Lenalidomide in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (firmMIND)
NCT05429268 · ClinicalTrials.gov ↗ · Large B-Cell Lymphoma, Diffuse Large B-Cell Lymphoma
Phase 3 Active, closed 2022-12 Ireland, UK
A Study to Evaluate Axatilimab Versus Best Available Therapy in Participants With Chronic Graft Versus Host Disease After at Least 2 Prior Lines of Systemic Therapy
NCT06821542 · ClinicalTrials.gov ↗ · Chronic Graft-versus-host-disease
Phase 3 Active, closed 2025-06 Ireland, UK
A Study to Evaluate the Safety, Tolerability of INCB160058 in Participants With Myeloproliferative Neoplasms
NCT06313593 · Myeloproliferative Neoplasms
Phase 1 Active, closed 2024-08 UK, USA
A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms
NCT05936359 · ClinicalTrials.gov ↗ · Myeloproliferative Neoplasms
Phase 1 Active, closed 2023-09 UK
INCB000928 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Anemia Due to Myeloproliferative Disorders
NCT04455841 · ClinicalTrials.gov ↗ · Anemia, Post-essential Thrombocythemia Myelofibrosis, Post-polycythemia Vera Myelofibrosis
Phase 1/2 Active, closed 2021-03 UK, USA
A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V1)
NCT06113445 · NonSegmental Vitiligo
Phase 3 Active, closed 2023-11 USA
A Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease
NCT06388564 · ClinicalTrials.gov ↗ · Chronic Graft-versus-host-disease
Phase 2 Active, closed 2024-10 UK, USA
A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V2)
NCT06113471 · ClinicalTrials.gov ↗ · NonSegmental Vitiligo
Phase 3 Active, closed 2023-11 UK, USA
Rollover Study to Provide Continued Treatment for Participants With B-Cell Malignancies Previously Enrolled in Studies of Parsaclisib (INCB050465)
NCT04509700 · ClinicalTrials.gov ↗ · B-Cell Malignancies
Phase 2 Active, closed 2020-08 UK, USA
Study of INCB123667 in Subjects With Advanced Solid Tumors
NCT05238922 · ClinicalTrials.gov ↗ · Solid Tumors
Phase 1 Active, closed 2022-07 UK, USA
Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms
NCT04279847 · ClinicalTrials.gov ↗ · Myelofibrosis, Myelodysplastic Syndrome, Myelodysplastic/Myeloproliferative Neoplasm Overlap Syndrome
Phase 1 Active, closed 2021-02 UK, USA, China
A Study to Evaluate INCB186748 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
NCT06818812 · ClinicalTrials.gov ↗ · Solid Tumors
Phase 1 Active, closed 2025-03 USA
A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma
NCT05851443 · ClinicalTrials.gov ↗ · Moderate to Severe Asthma
Phase 2 Active, closed 2023-07 USA
A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN2)
NCT06516965 · ClinicalTrials.gov ↗ · Prurigo Nodularis
Phase 3 Active, closed 2024-10 UK, USA
A Study to Assess the Efficacy and Safety of Ruxolitinib Cream in Children and Adolescents (6 to <18 Years Old) With Moderate Atopic Dermatitis
NCT06832618 · ClinicalTrials.gov ↗ · Atopic Dermatitis
Phase 3 Active, closed 2025-06 UK, USA
Safety and Pharmacokinetics Study of a Modified Tafasitamab IV Dosing Regimen Combined With Lenalidomide in R-R DLBCL Patients
NCT05222555 · ClinicalTrials.gov ↗ · Diffuse Large B Cell Lymphoma
Phase 1/2 Active, closed 2022-07 USA
A Study to Evaluate INCB099280 in Participants With Select Solid Tumors Who Are Immune Checkpoint Inhibitor Naive
NCT05879822 · ClinicalTrials.gov ↗ · Advanced Solid Tumor
Phase 2 Active, closed 2023-10 China
A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN1)
NCT06516952 · ClinicalTrials.gov ↗ · Prurigo Nodularis
Phase 3 Active, closed 2024-10 USA
An Open-Label Study to Enable Continued Treatment Access for Subjects Previously Enrolled in Studies of Ruxolitinib
NCT02955940 · ClinicalTrials.gov ↗ · Pancreatic Cancer, Colorectal Cancer (CRC), Breast Cancer
Phase 2 Active, closed 2016-11 USA
Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS1)
NCT06959225 · ClinicalTrials.gov ↗ · Hidradenitis Suppurativa
Phase 3 Active, closed 2025-06 USA
A Ph1b/2 Study of Axatilimab Monotherapy in Chinese Participants With Recurrent or Refractory cGVHD
NCT06843408 · ClinicalTrials.gov ↗ · Chronic Graft-versus-host-disease
Phase 1/2 Active, closed 2025-06 China

Registers list studies that are recruiting, about to open, active but closed to enrolment, or enrolling by invitation. The UK and USA registers cover industry-sponsored studies only. Titles and statuses are copied from the registry as published.

02

Incyte Corporation in the EU trials register (CTIS)

6 trials · 1 in Ireland

Authorised or ongoing trials in the EU Clinical Trials Information System with Incyte Corporation as sponsor. Some are the same study as a ClinicalTrials.gov record above; the two registries share no common ID. Trials with a site in Ireland are listed first.

StudyPhaseStatusCountries
A Phase 3, Randomized, Open-Label Study of INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum Resistant Ovarian Cancer With Cyclin E1 Overexpression (MAESTRA 2)
2025-522748-42-00 · CTIS ↗ · Neoplasms
Phase 3 Ongoing Ireland + 7 more
A Phase 1, Open-Label, Multicenter Study of INCA036978 in Participants With Myeloproliferative Neoplasms
2026-525217-31-00 · Neoplasms
Phase 1 Authorised Italy, Belgium, Germany + 2 more
A First-in-Human Study of INCA035784 in Participants With Myeloproliferative Neoplasms
2026-525360-18-00 · Neoplasms
Phase 1 Authorised Italy, Belgium, Germany
A Randomized, Double-Blind, Phase 3 Study of Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma (DAWN-303)
2025-525009-18-00 · CTIS ↗ · Neoplasms
Phase 3 Ongoing Poland, Italy, Netherlands + 9 more
A Phase 1, Open-Label, Multicenter Study of INCA036873 in Participants With Advanced Solid Tumors and Hematological Malignancies
2025-523130-11-00 · CTIS ↗ · Neoplasms
Phase 1 Ongoing Italy, Belgium, Denmark
A Randomized, Double-Blind, Phase 3 Study of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
2025-523735-19-00 · CTIS ↗ · Neoplasms
Phase 3 Ongoing Poland, France, Denmark + 7 more
03

Drugs in Incyte Corporation trials

41 compounds

Drugs and biologicals named as interventions in these trials, with the number of this sponsor's trials that name each one. Placebos and generic comparators are excluded.

+ 1 more in the trial list above.

04

Conditions in Incyte Corporation trials

43 conditions
05

By trial register

RegisterTrialsRecruiting
Clinical trials in USA4727
Clinical trials in UK2813
Clinical trials in China73
Clinical trials in Ireland62
EU register (CTIS)6—

A trial with sites in more than one country appears in each of those registers.

06

Other sponsors in Solid Tumors

SponsorTrials
EMD Serono Research & Development Institute2
ORIC Pharmaceuticals2
Zai Lab (Shanghai)2
Jacobio Pharmaceuticals2
Mabwell (Shanghai) Bioscience2
Hansoh BioMedical R&D Company2
Shandong Suncadia Medicine2
Shionogi1
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany1
Fortvita Biologics (USA)Inc1

Sponsors with the most current trials registered for this condition.

07

Questions about Incyte Corporation trials

How many clinical trials does Incyte Corporation sponsor?

Incyte Corporation is the lead sponsor of 53 current trials on ClinicalTrials.gov in our USA, UK, China and Ireland registers, and 6 authorised or ongoing trials in the EU register (CTIS), as of the registry sync on 26 September 2026. Completed and withdrawn studies are not counted.

Are Incyte Corporation trials recruiting?

Yes. 28 of its 53 ClinicalTrials.gov trials are recruiting. Eligibility and site contacts are on each trial's record. Only the study team can confirm whether a patient is eligible.

Which drugs is Incyte Corporation testing?

Its current trials name 41 drugs and biologicals as interventions. The most frequent are Ruxolitinib (16), Povorcitinib (9), Axatilimab (5), Bevacizumab (4) and INCA33890 (4). The number in brackets is how many of its trials name each drug.

Does Incyte Corporation have clinical trials in Ireland?

Yes. 6 trials in our Ireland register (ClinicalTrials.gov), and 1 trial in the EU register (CTIS) with a site in Ireland. Some may be the same study registered in both. See the Irish clinical trials register for sites and contacts.

Where does this information come from?

Every trial, status, phase and condition on this page is copied from public ClinicalTrials.gov and EU CTIS records by a daily sync, grouped by the sponsor name each registry records. It says nothing about the organisation beyond its registered trials, and it is not medical advice.

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How this page is built

Everything on this page is copied from public registry records — it is not written from memory, and nothing here describes the organisation beyond its registered trials. Each trial links to its own record so you can check it yourself.

This page is built automatically: a daily sync job reads the registry records behind our trial registers and groups every current trial by its lead sponsor name, ignoring legal-form suffixes such as Inc. or Ltd. A small, hand-checked list joins the same organisation's different registry names (for example its EU legal entity). There is no AI drafting and no per-sponsor editorial pass. The “last verified” date above is the timestamp of that sync, not a review date. Our general editorial approach is described in our editorial standards and corrections policy. The the registries data on this page was last retrieved on 26 Sep 2026.

Please verify before you rely on this. This page is general information for life-science and pharmaceutical professionals. It is not medical advice, and it has not been reviewed by a clinician — our editorial team holds life-science qualifications, not clinical ones. It is not exhaustive and may not reflect the most recent label change. Always check the official prescribing information (US Prescribing Information or EU SmPC) and speak to your doctor or pharmacist before acting on anything here. Drugs in the same class are not automatically interchangeable, and approvals, brand names and indications differ between the US, the EU/Ireland (EMA/HPRA) and other regions. Spotted an error? Tell us — we correct promptly and log it.