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Clinical Trials in the USA / NCT07213973
Recruiting Phase 2

Pharmacokinetics, Safety, and Efficacy of Povorcitinib in Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa

NCT07213973 · tracked via the Priya Life Science USA tracker
Sponsor
Incyte Corporation
Phase
Phase 2
Started
2026-02-02
Last updated
2026-08-06

Condition(s) studied

Hidradenitis Suppurativa (HS)

Investigational drug(s) / intervention(s)

Povorcitinib

Povorcitinib: Oral; Tablet

Study summary

The purpose of this study is to evaluate the pharmacokinetics, safety, and efficacy of povorcitinib in adolescent participants with moderate to severe hidradenitis suppurativa over a 54-week open-label treatment period.

Eligibility

Sex
ALL
Min age
12 Years
Max age
17 Years
Healthy volunteers
No
Inclusion Criteria: * Aged ≥ 12 to \< 18 years at the time of informed consent/assent signing. * Body weight ≥ 30 kg at both screening and baseline visits. * Diagnosis of moderate to severe HS for at least 3 months prior to the screening visit. * Total abscess and inflammatory nodule count of at least 5 at both the screening and baseline visits. * HS lesions corresponding to refined Hurley Stage IB, IC, IIB, IIC, or III at both the screening and baseline visits. * Documented history of inadequate response to at least a 3-month course of at least 1 conventional systemic therapy (oral antibiotic or biologic drug) for HS (or demonstrated intolerance to, or have a contraindication to, a conventional systemic therapy for treatment of their HS). * Agreement to use contraception. * Willing and able to comply with the study protocol and procedures. * Further inclusion criteria apply. Exclusion Criteria: * Presence of \> 20 draining tunnels (fistulas) at either the screening or baseline visit. * Women who are pregnant (or who are considering pregnancy) or breastfeeding. * Medical history including thrombocytopenia, coagulopathy or platelet dysfunction, Q-wave interval abnormalities, current or history of certain infections, cancer, lymphoproliferative disorders and other medical conditions at the discretion of the investigator. * Laboratory values outside of the protocol-defined ranges. * Further exclusion criteria apply.

Primary outcome measure(s)

Trial sites (30)

FacilityCityRegionStatus
University of Alabama At Birmingham Birmingham Alabama Recruiting
Medical Dermatology Specialists Phoenix Phoenix Arizona Recruiting
Saguaro Dermatology Phoenix Arizona Recruiting
Uconn Health Farmington Connecticut Recruiting
University of Miami Miller School of Medicine Miami Florida Recruiting
Skin Research of South Florida, Llc Miami Florida Recruiting
Trueblue Clinical Research Tampa Florida Recruiting
Advanced Medical Research Pc Sandy Springs Georgia Recruiting
Endeavor Health Medical Group Skokie Illinois Recruiting
Dermatology Skin Cancer Center Leawood Leawood Kansas Recruiting
Equity Medical Bowling Green Kentucky Recruiting
Johns Hopkins Univ Schl of Medicine Baltimore Maryland Recruiting
Skin Oasis Dermatology Gambrills Maryland Not Yet Recruiting
Boston Childrens Hospital Boston Massachusetts Recruiting
Oakland Hills Dermatology Pc Auburn Hills Michigan Recruiting
Wayne State University Physician Group Dermatology Detroit Michigan Recruiting
Revival Research Institute, Llc Troy Troy Michigan Recruiting
University of Missouri Kansas City Kansas City Missouri Not Yet Recruiting
Washington University St Louis Missouri Recruiting
Boeson Research Missoula 2825 Fort Missoula Rd Missoula Montana Recruiting
University of New Mexico Hospital Albuquerque New Mexico Recruiting
Geisinger Medical Center Danville Pennsylvania Recruiting
Bellaire Dermatology Associates Bda Bellaire Texas Recruiting
Texas Dermatology Research Center Dallas Texas Recruiting
3A Research Llc West Location El Paso Texas Not Yet Recruiting
Jordan Valley Dermatology Center South Jordan Utah Recruiting
Dermcare Clinic Mississauga Ontario Recruiting
York Dermatology Center Richmond Hill Ontario Recruiting
The Hospital For Sick Children Toronto Ontario Recruiting
Skincare Studio Dermatology Centre St. John's Canada Recruiting

More Incyte Corporation trials in the USA

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07213973 on ClinicalTrials.gov ↗ ← All trials in the USA